The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges

He, Jiaxuan; Liu, Fan; Xu, Ting; Ma, Jiahui; Yu, Haiyang; Zhao, Jing; Xie, Yanyan; Luo, Li; Yang, Qinsi; Lou, Ting; He, Luqing; Sun, Da

doi:10.1016/j.biopha.2023.115807

“…122 Future diagnosis of hydrogen markers based on hydrogen-producing bacteria will provide a new perspective for the diagnosis and prevention of Alzheimer's disease. 123 Whether hydrogen can be used as a diagnostic biomarker of SCI in the future needs further research.…”

Section: Clinical Therapeutic Studies Of Hydrogen Therapy For Disease...mentioning

confidence: 99%

The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury

Hu,

Li,

Lin

et al. 2024

DDDT

1

0

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Hydrogen, which is a novel biomedical molecule, is currently the subject of extensive research involving animal experiments and in vitro cell experiments, and it is gradually being applied in clinical settings. Hydrogen has been proven to possess anti-inflammatory, selective antioxidant, and antiapoptotic effects, thus exhibiting considerable protective effects in various diseases. In recent years, several studies have provided preliminary evidence for the protective effects of hydrogen on spinal cord injury (SCI). This paper provides a comprehensive review of the potential molecular biology mechanisms of hydrogen therapy and its application in treating SCI, with an aim to better explore the medical value of hydrogen and provide new avenues for the adjuvant treatment of SCI.

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Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing

Mi,

Liu,

Wang

et al. 2024

Angewandte Chemie

0

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We describe small heterojunction polymer dots (Pdots) with deep‐red light catalyzed H2 generation for diabetic skin wound healing. The Pdots with donor/acceptor heterojunctions showed remarkably enhanced photocatalytic activity as compared to the donor or acceptor nanoparticles alone. We encapsulate the Pdots and ascorbic acid into liposomes to form Lipo‐Pdots nanoreactors, which selectively scavenge •OH radicals in live cells and tissues under 650 nm light illumination. The antioxidant capacity of the heterojunction Pdots is ~10 times higher than that of the single‐component Pdots described previously. Under a total light dose of 360 J/cm2, the Lipo‐Pdots nanoreactors effectively scavenged •OH radicals and suppressed the expression of pro‐inflammatory cytokines in skin tissues, thereby accelerating the healing of skin wounds in diabetic mice. This study provides a feasible solution for safe and effective treatment of diabetic foot ulcers.

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Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing

Mi,

Liu,

Wang

et al. 2024

Angew Chem Int Ed

1

0

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We describe small heterojunction polymer dots (Pdots) with deep‐red light catalyzed H2 generation for diabetic skin wound healing. The Pdots with donor/acceptor heterojunctions showed remarkably enhanced photocatalytic activity as compared to the donor or acceptor nanoparticles alone. We encapsulate the Pdots and ascorbic acid into liposomes to form Lipo‐Pdots nanoreactors, which selectively scavenge •OH radicals in live cells and tissues under 650 nm light illumination. The antioxidant capacity of the heterojunction Pdots is ~10 times higher than that of the single‐component Pdots described previously. Under a total light dose of 360 J/cm2, the Lipo‐Pdots nanoreactors effectively scavenged •OH radicals and suppressed the expression of pro‐inflammatory cytokines in skin tissues, thereby accelerating the healing of skin wounds in diabetic mice. This study provides a feasible solution for safe and effective treatment of diabetic foot ulcers.

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The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges

Cited by 7 publications

References 181 publications

The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury

The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury

Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing

Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing

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