The Role of Hyperuricemia in Human Morbidity, and Treatment Options

Eliseeva, M.E.; Елисеев, М. С.

doi:10.31550/1727-2378-2019-157-2-47-54

Cited by 5 publications

(2 citation statements)

References 63 publications

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“…Ранее сообщалось [13], что уменьшение массы тела сопровождается снижением сывороточного уровня МК за счет увеличения выведения ее почками и частично -за счет угнетения выработки урата. Повышение сывороточного уровня МК на каждый 1 мг/дл сопровождается возрастанием риска смерти от всех причин на 9% и риска развития ССЗ на 20% [14].…”

Section: факторы риска сердечно-сосудистых заболеванийunclassified

Assessment of inflammatory biomarkers and risk factors for cardiovascular diseases in overweight and obesity

Murkamilov,

Aitbaev,

Fomin

et al. 2024

Cardiovasc Ther Prev

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Aim. To study biomarkers of inflammation in overweight and obese individuals.Material and methods. A total of 180 people with overweight or obesity were included. Anthropometric and biochemical parameters were determined in all patients. The concentrations of C-reactive protein (CRP), fibrinogen, interleukin (IL)-6, IL-10, and tumor necrosis factor alpha (TNF-α) were studied.Results. The following significant correlations have been established: IL-6 — with the levels of central aortic pressure, systolic and diastolic blood pressure (BP), heart rate (HR), levels of glucose, uric acid, low-density lipoprotein cholesterol (LDL-C); TNF-α — with concentrations of uric acid, triglycerides, cystatin C, creatinine and glomerular filtration rate; CRP — with body mass index, diastolic BP, heart rate, levels of uric acid, LDL-C, cystatin C. A significant correlation of IL-6, IL-10 and TNF-α with the proteinuria level was established.Conclusion. In individuals with overweight or obesity, a direct correlation was found between serum concentrations of IL-6 and levels of BP, heart rate, lipids, carbohydrates, uric acid and proteinuria. In overweight or obesity, the serum TNF-α level has a direct correlation with hyperuricemia, hyperfibrinogenemia, hypertriglyceridemia, proteinuria and reduced renal filtration function, and the level of CRP is associated with an increase in diastolic BP, heart rate, uric acid, fibrinogen, LDL-C and cystatin C.

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Section: факторы риска сердечно-сосудистых заболеванийunclassified

Assessment of inflammatory biomarkers and risk factors for cardiovascular diseases in overweight and obesity

Murkamilov,

Aitbaev,

Fomin

et al. 2024

Cardiovasc Ther Prev

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“…Кроме того, как подагра, так и ГУ ассоциированы с развитием артериальной гипертензии (АГ) и других сердечно-сосудистых заболеваний, развитием цереброваскулярных заболеваний и снижением почечной функции, ожирением и метаболическим синдромом. Повышение уровня МК на каждый 1 мг/дл приводит к возрастанию риска общей смерти на 9% и риска развития ССЗ на 20% [10][11][12].…”

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The effect of bariatric surgery on purine metabolism and gout

Panevin¹,

Елисеев²,

Shestakova³

2020

Obes. metabol.

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Gout is an auto-inflammatory tophaceous disease characterized by the deposition of crystals of monosodium urate and developing in connection with this inflammation in people with hyperuricemia (HU). Except to genetic factors, risk factors for the development of HU and gout are many modifiable factors, including metabolic syndrome and obesity, and their correction is the most important component of successful disease control. Obesity can change the clinical picture of gout, characterized by an earlier onset, a large number of affected joints. Weight loss helps reduce uric acid (UA) serum levels. Bariatric / metabolic surgery significantly reduces the incidence of comorbid obesity and mortality, and is by far the most effective way to combat obesity. In addition to improving health, an important goal of bariatric surgery is to improve the quality of life. Bariatric surgery can prevent the development of HU in subjects with an initially normal level of serum UA before surgery. The dynamics of the concentration of UA in serum can be a predictor of successful bariatric surgery and help in predicting the severity of postoperative weight loss. The decrease in body weight after bariatric surgery leads to a decrease in UA in the long-term postoperative period, however, there is a high frequency of acute gout attacks in the early postoperative period. Thus, bariatric surgery has a significant effect on HU and gout and can be an effective treatment for this disease.

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Hyperuricemia and its clinical significance

Karabaeva¹

2022

Clinical Medicine and Pharmacology

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The issues of the pathogenesis of hyperuricemia currently remain relevant due to the steady increase in the frequency of hyperuricemia and gout in polymorbid pathologies. Currently, a sufficient number of scientific papers have been accumulated on the association of hyperuricemia with cardiovascular diseases and their consequences (stroke and myocardial infarction), metabolic syndrome, arterial hypertension, insulin resistance, type 2 diabetes mellitus, chronic kidney disease, lipid metabolism disorders, atrial fibrillation, with the risk of mortality.

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The Role of Hyperuricemia in Human Morbidity, and Treatment Options

Cited by 5 publications

References 63 publications

Assessment of inflammatory biomarkers and risk factors for cardiovascular diseases in overweight and obesity

Assessment of inflammatory biomarkers and risk factors for cardiovascular diseases in overweight and obesity

The effect of bariatric surgery on purine metabolism and gout

Hyperuricemia and its clinical significance

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