The role of hypothalamic histamine in leptin-induced suppression of short-term food intake in fasted rats

Toftegaard, C. L.; Knigge, Ulrich; Kjær, Andreas; Warberg, Jørgen

doi:10.1016/s0167-0115(02)00260-4

Cited by 34 publications

(29 citation statements)

References 60 publications

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“…H 3 receptor KO mice display changes in behavioral states, reduced locomotion (Toyota et al, 2002;Schneider et al, 2014b), a metabolic syndrome with hyperphagia, late-onset obesity, increased insulin and leptin levels (Toftegaard et al, 2003;Yoshimoto et al, 2006), and an increased severity of EAE, a model of multiple sclerosis (Teuscher et al, 2004. By comparing EAEsusceptible and -resistant mice strains as well as H 3 receptor KO mice, a functional link between central H 3 receptor signaling and peripheral immune responses was proposed (Krementsov et al, 2013).…”

Section: Functionmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

et al. 2015

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Section: Functionmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

et al. 2015

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“…We now know that brain histamine is involved in feeding physiology by modulating the release of neurotransmitters and hormones that drive or inhibit feeding [48] (Fig. 1).…”

Section: Brain Histamine and Feeding Behaviormentioning

confidence: 99%

Histamine in the brain: Beyond sleep and memory

Passani¹,

Giannoni²,

Bucherelli

et al. 2007

Biochemical Pharmacology

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“…Both blockade of histamine synthesis and blockade of the H 1 receptors attenuated the response to leptin [35, 39, 40]. Also, leptin facilitated histamine release from the hypothalamus [41].…”

Section: Histamine and Leptinmentioning

confidence: 99%

Histamine and the Regulation of Body Weight

Jørgensen

Knigge²,

Warberg³

et al. 2007

Neuroendocrinology

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Energy intake and expenditure is regulated by a complex interplay between peripheral and central factors. An exhaustive list of peptides and neurotransmitters taking part in this complex regulation of body weight exists. Among these is histamine, which acts as a central neurotransmitter. In the present article we review current evidence pointing at an important role of histamine in the regulation of appetite and metabolism. Studies using both knockout mouse models as well as pharmacological studies have revealed that histamine acts as an anorexigenic agent via stimulation of histamine H₁ receptors. One effect of histamine in the regulation of appetite is to act as a mediator of the inhibitory effect of leptin on appetite. It seems that histamine may attenuate and delay the development of leptin resistance in high-fat-diet-induced obesity. Furthermore, histamine may also act to accelerate lipolysis. Based on the current evidence of the involvement of histamine in the regulation of body weight, the histaminergic system is an obvious target for the development of pharmacological agents to control obesity. At present, H₃ receptor antagonists that stimulate the histaminergic system may be the most promising histaminergic drugs for antiobesity therapy.

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The role of hypothalamic histamine in leptin-induced suppression of short-term food intake in fasted rats

Cited by 34 publications

References 60 publications

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

Histamine in the brain: Beyond sleep and memory

Histamine and the Regulation of Body Weight

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