The role of hypothalamo-sympathetic nerve system to maintain high blood pressure in DOCA hypertensive rats.

Takeda, Kazuo; Sasaki, Susumu; Kaimasu, Isao; Yoshimura, Minabu; Nakagawa, Masao; Ijichi, Hamao; Buñag, Ruben D.

doi:10.1253/jcj.44.409

Cited by 4 publications

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“…An increase in the neurogenic vasoconstrictor tone of the isolated hindlimb has also been demonstrated. 22 Dahl salt-sensitive rats' 3 and DOC-saline-treated animals 23 have been shown to have exaggerated depressor responses to ganglionic blockade, which suggested an increased functional contribution of the sympathetic nervous system. As a result, an increased neurogenic component that maintains arterial pressure was predicted in the Grollman-wrapped rats given a high sodium diet.…”

Section: Discussionmentioning

confidence: 99%

Contribution of vasopressin and the sympathetic nervous system in the early phase of high sodium one-kidney renal hypertension.

Hinojosa

Haywood

1984

Hypertension

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SUMMARY This study assessed the contributions of the sympathetic nervous system and arginine vasopressin to the onset of one-kidney, one-wrap (1K1VV) renal hypertension in rats fed a high sodium diet. Two weeks before renal wrap or sham wrap, rats were given a high sodium diet and water ad libitum. At 3 days postwrap, resting mean arterial pressure (MAP) was significantly greater in renalwrapped rats. The contributions of the sympathetic nervous system and vasopressin to blood pressure (BP) were assessed by ganglionic blockade and vascular vasopressin receptor antagonism, respectively. Depressor responses to ganglionic blockade were significantly greater in the normotensive rats as compared to the hypertensive rats. Administration of vasopressin antagonist caused a significant fall in pressure only in wrapped rats. In addition, enhanced pressor responses to bolus injections of vasopressin were observed in hypertensive rats. These results indicate that during this phase of the hypertension there is an activation of the vasopressin pressor system without an increase in neurogenic function. Equalization of arterial pressure occurred only when both systems were blocked, regardless of the order of blockade, which indicated that the sympathetic nervous system and vasopressin interact to maintain the hypertension. Comparison of depressor responses to the blocking agents revealed that the interaction is compensatory in nature since the contributions of the sympathetic nervous system and vasopressin to the maintenance of arterial pressure were greater when the other system was blocked. (Hypertension 6: 848-854, 1984) KEY WORDS • arterial pressure one-kidney, one-wrap hypertension vasopressin antagonist • ganglionic blockade T HE harmful effects of dietary sodium in the pathogenesis of hypertension are under considerable debate, 1 " 3 but evidence favors the concept that predisposing factors are necessary for the level of arterial pressure to be sensitive to salt intake. 4 To study the contribution of sodium to hypertension, several experimental models have been developed that require a high sodium intake for the expression of increased arterial pressure. These high sodium models of hypertension include the deoxycorticosterone-saline (DOC-saline) model, the Dahl salt-sensitive strain of rats, and the reduced renal mass-saline model. Mohring et al. 3 and Korner et al. 6 have studied the effects of increases in sodium intake in chronically renal hypertensive animals. Their results indicated that elevated

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Section: Discussionmentioning

confidence: 99%

Contribution of vasopressin and the sympathetic nervous system in the early phase of high sodium one-kidney renal hypertension.

Hinojosa

Haywood

1984

Hypertension

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“…The clearance of [ 3 H]NE was also similar in normotensive and hypertensive rats. However, the calculated apparent rate of release of norepinephrine was significantly elevated, by 27%, in the hypertensive rats (68.3±5.4 versus 53.7±4.2 ng min" 1 • kg" 1 ).…”

Section: Clearance Of [ 3 H]norepinephrine and Apparent Rate Of Norepmentioning

confidence: 86%

“…/-[ring-2,5,6-3 H]-Norepinephrine (specific activity, 38-44 Ci/mM; New England Nuclear, Boston) was infused at a rate of 0.13 ^Ci min" 1 • kg" 1 (286,000 dpm min" 1 • kg" 1 ). On the day of the experiment, [ 3 H]NE stock solution was added to saline containing 0.2N acetic acid, 0.5 mg/ml sodium sulfite, and 0.2 mg/ml reduced glutathione to prevent oxidation of the catecholamines.…”

Section: Clearance Of [ 3 H]norepinephrine and Determination Of Apparmentioning

confidence: 99%

“…Each observation supports other data showing that sodium-dependent hypertension is maintained by the sympathetic nervous system. Studies using ganglionic blockade to assess the functional contribution of the sympathetic nervous system to blood pressure have shown that DOC-saline-treated rats 1 and Dahl saltsensitive rats 7 fed a high sodium diet respond to ganglionic blockade with greater depressor responses than their respective controls. In addition, hypertension in DOC-saline-treated rats and Dahl salt-sensitive rats fed a high sodium diet can be prevented by the depletion of peripheral catecholamines with 6-hydroxydopamine or guanethidine pretreatment.…”

Section: Clearance Of [ 3 H]norepinephrine and Apparent Rate Of Norepmentioning

confidence: 99%

“…Several indexes of augmented sympathetic nervous system function have been documented in sodium-dependent hypertension. In deoxycorticosterone (DOC)-saline hypertension in rats, an exaggerated depressor response to ganglionic blockade, 1 elevations in plasma catecholamines, 2 increases in norepinephrine turnover, 34 and an augmented apparent rate of release of norepinephrine 5 have been observed. In addition, peripheral chemical sympathectomy with 6-hydroxydopamine 6 is effective in preventing this model of hypertension.…”

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Sympathetic nervous system in high sodium one-kidney, figure-8 renal hypertension.

1992

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The contribution of the sympathetic nervous system and vasopressin to the maintenance of arterial pressure was investigated in high sodium-fed rats 4 weeks after the induction of one-kidney, figure-8 renal wrap hypertension. Arterial pressure was significantly greater In renal-wrapped rats than in shamoperated animals. The contribution of the sympathetic nervous system was assessed functionally by measuring the arterial pressure response to ganglionic blockade and estimating the apparent rate of release of norepinephrine. The contribution of vasopressin was assessed by administration of the vascular antagonist

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Brain neurotransmitters and the development and maintenance of experimental hypertension

Buccafusco

Brezenoff

1986

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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The role of hypothalamo-sympathetic nerve system to maintain high blood pressure in DOCA hypertensive rats.

Cited by 4 publications

References 0 publications

Contribution of vasopressin and the sympathetic nervous system in the early phase of high sodium one-kidney renal hypertension.

Contribution of vasopressin and the sympathetic nervous system in the early phase of high sodium one-kidney renal hypertension.

Sympathetic nervous system in high sodium one-kidney, figure-8 renal hypertension.

Brain neurotransmitters and the development and maintenance of experimental hypertension

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