The Role of Hysteroscopic Biopsy in Obtaining Specimens for Cytogenetic Evaluation in Missed Abortion prior to Suction Dilatation and Curettage

Awonuga, Awoniyi O.; Jelsema, J.; Abdallah, M.; Berman, Jay M.; Diamond, Michael P.; Puscheck, Elizabeth E.

doi:10.1159/000316262

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…In contrast, [24] found that direct hysteroscopic sampling did not improve the sensitivity of cytogenetics for aneuploidy detection when compared with conventional suction D&C.…”

Section: Author Contributionsmentioning

confidence: 79%

Hysteroscopic Evaluation of the Uterine Cavity in Women with First-Trimester Missed Miscarriage: Case Series

Altraigey¹,

Nosseir²,

Abbas³

et al. 2017

Journal of Gynecology Research

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The aim of this study was to identify the value of hysteroscopy in detection of the relationship between missed miscarriage and intrauterine pathologies. The study was held at the Department of Obstetrics and Gynaecology, Benha University. It included 90 women with 1 st trimester missed miscarriage who were examined by diagnostic hysteroscopy immediately before dilatation and curettage (D&C) and 6-8 weeks after D&C (second look hysteroscopy). Incomplete uterine septum was found in 22.2% of cases; 70% of them had a previous history of missed miscarriage. Intrauterine adhesions were found in 6.7% of cases before D&C and in 16.7% after D&C. In cases of missed miscarriage either before or after D&C, hysteroscopy is an easy and effective tool for diagnosis of the site of the sac and the presence of intrauterine pathology.Abstract

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“…In contrast, [24] found that direct hysteroscopic sampling did not improve the sensitivity of cytogenetics for aneuploidy detection when compared with conventional suction D&C.…”

Section: Author Contributionsmentioning

confidence: 79%

Hysteroscopic Evaluation of the Uterine Cavity in Women with First-Trimester Missed Miscarriage: Case Series

Altraigey¹,

Nosseir²,

Abbas³

et al. 2017

Journal of Gynecology Research

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“…Spontaneous abortions occur in approximately 10% to 15% of all pregnancies and can be caused by various factors, including anatomic, endocrine, infectious, metabolic, immunologic, hematologic, and chromosomal abnormalities [1]. Pregnancy loss in infertile couples justify efforts to investigate for the underlying cause.…”

Section: Introductionmentioning

confidence: 99%

Increased Fetal Chromosome Detection with the Use of Operative Hysteroscopy During Evacuation of Products of Conception for Diagnosed Miscarriage

Cholkeri-Singh

Zamfirova

Miller

2020

Journal of Minimally Invasive Gynecology

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To determine whether incorporation of operative hysteroscopy with biopsy of products of conception, in conjunction with a suction curettage for a first trimester missed abortion, affected the rate of maternal cell contamination when chromosomal analysis was performed on the products of conception, and to determine the rates of retained products of conception with incorporation of hysteroscopy after suction curettage. Design: Retrospective chart study. Setting: Private, minimally invasive surgery and infertility practice with academic-community hospital affiliation. Patients: Infertility patients undergoing evacuation of products of conception for documented first trimester miscarriages between 2006 and 2017. Interventions: Suction curettage or hysteroscopic biopsy and suction curettage, followed by chromosomal analysis of products of conception for determination of fetal genetics. Measurements and Results: A total of 264 charts were analyzed. Patients were categorized into 2 groups based on surgical collection of products of conception: group 1 (N = 174), suction curettage only, and group 2 (N = 90), a single procedure consisting of operative hysteroscopy with biopsy of products of conception followed by suction curettage and then diagnostic hysteroscopy to look for retained products. Data for chromosome detection and retained products of conception were available for 246 and 239 patients, respectively. No significant differences were detected between the groups for age, body mass index, ethnicity, gravida, parity, primary infertility, secondary infertility, spontaneous conception, single or multiple gestation, and surgical complications. Fetal chromosome detection was significantly higher without maternal contamination in group 2 (88.5%) compared with group 1 (64.8%) (p < .001). There was no significant between-group difference in postoperative retained products of conception. Conclusion: Obtaining fetal genetics can be useful when planning for a future successful pregnancy. The addition of operative hysteroscopy to biopsy the gestational sac, chorionic villi, and/or fetus significantly decreases the risk of maternal contamination and increases the ability to detect fetal chromosomes for genetic analysis without an increased risk of surgical complications. Despite the low risk of surgical complications, immediate second-look hysteroscopy after the completion of suction evacuation does not reduce the risk of postoperative retained products of conception.

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Comparison of Clinical Efficacy of Three Methods for Cervical Ripening followed by Surgical Evacuation in Early Missed Abortion

Wang

Huang

Zeng

et al. 2012

Journal of Reproduction and Contraception

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The Role of Hysteroscopic Biopsy in Obtaining Specimens for Cytogenetic Evaluation in Missed Abortion prior to Suction Dilatation and Curettage

Cited by 4 publications

References 30 publications

Hysteroscopic Evaluation of the Uterine Cavity in Women with First-Trimester Missed Miscarriage: Case Series

Hysteroscopic Evaluation of the Uterine Cavity in Women with First-Trimester Missed Miscarriage: Case Series

Increased Fetal Chromosome Detection with the Use of Operative Hysteroscopy During Evacuation of Products of Conception for Diagnosed Miscarriage

Comparison of Clinical Efficacy of Three Methods for Cervical Ripening followed by Surgical Evacuation in Early Missed Abortion

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