The role of <i>CLOCK</i> gene in psychiatric disorders: Evidence from human and animal research

Schuch, Jaqueline Bohrer; Genro, Júlia Pasqualini; Bastos, Clarissa Ribeiro; Ghisleni, Gabriele; Tovo‐Rodrigues, Luciana

doi:10.1002/ajmg.b.32599

Cited by 63 publications

(45 citation statements)

References 180 publications

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“…CLOCK is one of the most important genes of the endogenous master clock system. The main function of this gene relies on the transcription activation of downstream core clock genes and on the promotion of rhythmic chromatin opening, also regulating DNA accessibility of other transcription factors [11]. In humans, the CLOCK gene has already been associated with the evening chronotype as well as with some circadian and sleep disorders, such as delayed sleep phase syndrome [11].…”

Section: Introductionmentioning

confidence: 99%

“…An understanding of the role of relevant molecular mechanisms for the association between both phenotypes may provide important information to predict ADHD or sleep problems. Few candidate gene studies in humans have explored such mechanisms, and the CLOCK gene has been the most investigated [11,17,18,19]. All studies investigating the association between the CLOCK gene and ADHD focused only on one genetic variant: The 3’UTR rs1801260 SNP.…”

Section: Introductionmentioning

confidence: 99%

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CLOCK Polymorphisms in Attention-Deficit/Hyperactivity Disorder (ADHD): Further Evidence Linking Sleep and Circadian Disturbances and ADHD

Carpena

Hutz

Salatino-Oliveira

et al. 2019

Genes

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Circadian and sleep disorders, short sleep duration, and evening chronotype are often present in attention-deficit/hyperactivity disorder (ADHD). CLOCK, considered the master gene in the circadian rhythm, has been explored by few studies. Understanding the relationship between ADHD and CLOCK may provide additional information to understand the correlation between ADHD and sleep problems. In this study, we aimed to explore the association between ADHD and CLOCK, using several genetic markers to comprehensively cover the gene extension. A total of 259 ADHD children and their parents from a Brazilian clinical sample were genotyped for eight single nucleotide polymorphisms (SNPs) in the CLOCK locus. We tested the individual markers and the haplotype effects using binary logistic regression. Binary logistic and linear regressions considering ADHD symptoms among ADHD cases were conducted as secondary analysis. As main result, the analysis showed a risk effect of the G-A-T-G-G-C-G-A (rs534654, rs1801260, rs6855837, rs34897046, rs11931061, rs3817444, rs4864548, rs726967) haplotype on ADHD. A suggestive association between ADHD and rs534654 was observed. The results suggest that the genetic susceptibility to circadian rhythm attributed to the CLOCK gene may play an important role on ADHD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CLOCK Polymorphisms in Attention-Deficit/Hyperactivity Disorder (ADHD): Further Evidence Linking Sleep and Circadian Disturbances and ADHD

Carpena

Hutz

Salatino-Oliveira

et al. 2019

Genes

Self Cite

View full text Add to dashboard Cite

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“…Circadian rhythms are physiologic or behavioral cycles with a recurring periodicity of approximately 24 hr and can be measured as daily oscillations of hormones (melatonin, cortisol), core body temperature, rest‐activity cycles or transcriptome patterns [Bhadra, Thakkar, Das, & Pal Bhadra, ]. There is good evidence that circadian rhythm sleep–wake disorders (CRSWDs) play a role in many psychiatric illnesses such as depression, posttraumatic stress disorder, and eating disorders, which are often comorbid with ASD [Schuch, Genro, Bastos, Ghisleni, & Tovo‐Rodrigues, ]. These CRSWDs are characterized by blunted amplitude and altered circadian phase [Boivin, ; Wirz‐Justice, Bromundt, & Cajochen, ].…”

Section: Introductionmentioning

confidence: 99%

Sleep problems in adults with autism spectrum disorder and intellectual disability

Ballester

Martı́nez

Javaloyes³

et al. 2018

Autism Research

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Sleep problems (SP) are recognized as a common comorbid condition in autism spectrum disorder (ASD) and can influence core autism symptoms and mental and physical health. SPs can be lifelong and have been reported that adults on the autistic spectrum with and without intellectual disability (ID) present SPs (longer sleep latency, frequent night awakenings, and circadian rhythm sleep-wake disorders). A prospective, objective sleep study was conducted in 41 adults with ASD (33 AE 6 years old) and ID and 51 typically developing adults (33 AE 5 years old) using ambulatory circadian monitoring (ACM) recording wrist temperature, motor activity, body position, sleep, and light intensity. The findings indicated that individuals with ASD presented sleep difficulties including low sleep efficiency, prolonged sleep latency and increased number and length of night awakenings, together with daily sedentary behavior, and increased nocturnal activity. Furthermore, indications of an advanced sleepwake phase disorder were found in these autistic adults. Examining sleep and markers of the circadian system showed significant differences between adults with ASD and ID and an age-matched, healthy adult population. The sleep disturbances described for this sample of adults with ASD and ID are similar to those of already described for adults with ASD without ID; their relationship with intellectual ability should be further studied. Improving knowledge of sleep patterns in ASD adults with ID might help to designed targeted interventions to improve their functioning and reduce family stress. Autism Research 2019, 12: 66-79.Lay Summary: SPs are very frequent in autism from childhood to adulthood. We recorded sleep with a watch-like device in adults with autism and ID and compared sleep patterns with nonautistic volunteers. Results showed poorer sleep conditions in adults with autism (increased sleep latency and number/length of night awakenings) that resulted in decreased sleep efficiency. Increasing knowledge of the SPs in adults on the autism spectrum will allow to improve their and their families' quality of life.

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“…With negative psychological symptoms∗rs1801260 (CC) as the reference, the interaction of positive psychological symptoms∗rs1801260 (TT) was a risk factor for sleep disorders (OR = 10.833, 95% CI: 2.987–39.288). Schuch et al [ 50 ] believe that changes in the CLOCK gene coexist with common mental diseases and circadian rhythm disorders. The interaction between CLOCK gene rsll932595 and ARNTL gene rsl1824092 was associated with sleep disorders in patients with bipolar disorder [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Schuch et al [50] believe that changes in the CLOCK gene coexist with common mental diseases and circadian rhythm disorders. The interaction between CLOCK gene rsll932595 and ARNTL gene rsl1824092 was associated with sleep disorders in patients with bipolar disorder [32].…”

mentioning

confidence: 99%

Relationship between Mental Health, the CLOCK Gene, and Sleep Quality in Surgical Nurses: A Cross-Sectional Study

Shi

Liu

Jiang

et al. 2020

BioMed Research International

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Nursing is a high-risk occupation with high exposure to stress. The physical and mental health of nurses is directly related to the quality of medical services. Therefore, the sleep quality of nurses should not be ignored. In this study, the method of cluster random sampling was adopted from May to September 2019, and a questionnaire survey was conducted among 521 surgical nurses from five affiliated hospitals of Xinjiang Medical University. The relationship between mental health and sleep quality was analyzed, and 20% of the participants with sleep disorders were randomly selected. The sleep disorders used 1 : 1 matching, finally providing a sample with 60 cases and 60 controls for measurement of the CLOCK gene (rs1801260, rs6850524), to analyze the effect of the interaction between mental health and the CLOCK gene on sleep. The mental health and sleep quality of the surgical nurses were evaluated using the Symptom Checklist 90 (SCL-90) and Pittsburgh Sleep Quality Index (PSQI). The study found that surgical nurses had poor sleep, and there were differences associated with age, years working, frequency of night shifts, and incidence of sleep disorders under marital status (p<0.05). The PSQI scores of the positive psychological symptoms were higher than those of the negative psychological symptoms. The rank sum test was used to compare the sleep quality scores of different genotypes in CLOCK rs1801260 and rs6850524; the results indicated that the PSQI scores were different among different genotypes at the rs1801260 and rs6850524 loci. The logistic regression results suggested that CLOCK gene rs1801260 (TC) and positive psychological symptoms were influential factors for sleep disorders, and the interaction of positive psychological symptoms∗rs1801260 (TT) was a risk factor for sleep disorders (OR=10.833, 95% CI: 2.987–39.288). The sleep quality of nurses is not only affected by demographic characteristics but also affected by mental health status and the CLOCK gene.

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The role of CLOCK gene in psychiatric disorders: Evidence from human and animal research

Cited by 63 publications

References 180 publications

CLOCK Polymorphisms in Attention-Deficit/Hyperactivity Disorder (ADHD): Further Evidence Linking Sleep and Circadian Disturbances and ADHD

CLOCK Polymorphisms in Attention-Deficit/Hyperactivity Disorder (ADHD): Further Evidence Linking Sleep and Circadian Disturbances and ADHD

Sleep problems in adults with autism spectrum disorder and intellectual disability

Relationship between Mental Health, the CLOCK Gene, and Sleep Quality in Surgical Nurses: A Cross-Sectional Study

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