The Role of Ia Antigens in T Cell Activation

Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis.

“…Receivedfor publication 24 June 1985 and in revisedform 26 November 1985. The highly polymorphic cell surface glycoproteins encoded within the human major histocompatibility complex (MHC)' serve to restrict the recognition of antigen by T cells (1,2). Recognition of epitopes on nominal antigens, together with MHC determinants, is a necessary event for the activation of T lymphocytes.…”

Differential expression of Ia molecules by human monocytes.

“…Expression of Ia molecules by accessory cells, such as peripheral blood adherent monocytes (Mq),' is necessary for their ability to initiate and regulate immune reactivity (1)(2)(3)(4). In mice, two Ia molecules, I-E and I-A, encoded for by genes within the I region have been described.…”

Molecular biology of Type 1 (insulin-dependent) diabetes mellitus

“…5) and represent two dissimilar subunits called a and fl chains, being approximately Mr 34000 and Mr 28000, respectively. These heterodimeric proteins are expressed on the surface of immune competent cells and are important to the regulation of the immune response [55][56][57]. Recent molecular cloning of HLA-D region genes [58,59] have revealed that each locus of the HLA-D region codes for one or several a or fl chains (Fig.…”