The Role of IACUCs in Responsible Animal Research

Mohan, Swapna; Huneke, Richard B.

doi:10.1093/ilar/ilz016

Cited by 27 publications

(19 citation statements)

References 31 publications

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“…Highly distressed laboratory animals may lead to unreliable conclusions and/or unnecessary changes in scientific output, thereby affecting the reliability and repeatability of experiments, therefore every effort should be made to reduce unnecessary harm to them [ 9 ]. Although all countries have successively introduced laws and policies on animal welfare, and have even established animal protection organizations to supervise the regulations [ 19 , 20 ], Olsson [ 21 ] and other researchers have also discussed how better to promote the issue. However, efforts on animal welfare remain unsatisfactory.…”

Section: Discussionmentioning

confidence: 99%

“…These guidelines (ARRIVE) aimed to maximize the output of animal research by optimizing the information provided in [9]. Although all countries have successively introduced laws and policies on animal welfare, and have even established animal protection organizations to supervise the regulations [19,20], Olsson [21] and other researchers have also discussed how better to promote the issue. However, efforts on animal welfare remain unsatisfactory.…”

Section: Methods Sectionmentioning

confidence: 99%

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Quality of interventional animal experiments in Chinese journals: compliance with ARRIVE guidelines

et al. 2020

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Background In view of the inadequacy and incompleteness of currently-reported animal experiments and their overall poor quality, we retrospectively evaluated the reporting quality of animal experiments published in Chinese journals adhering to the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines. Results The databases CNKI, WanFang, VIP, and CBM were searched from inception until July 2018. Two appropriately-trained reviewers screened and extracted articles independently. The ARRIVE guidelines were used to assess the quality of the published reports of animal experiments. The compliance rate of every item was analyzed relative to their date of publication. A total of 4342 studies were included, of which 73.0% had been cited ≤5 times. Only 29.0% (1261/4342) were published in journals listed in the Chinese Science Citation Database. The results indicate that the compliance rate of approximately half of the sub-items (51.3%, 20/39) was less than 50%, of which 65.0% (13/20) was even less than 10%. Conclusions The reporting quality of animal experiments in Chinese journals is not at a high level. Following publication of the ARRIVE guidelines in 2010, the compliance rate of the majority of its requirements has improved to some extent. However, less attention has been paid to the ethics and welfare of experimental animals, and a number of specific items in the Methods, Results, and Discussion sections continue to not be reported in sufficient detail. Therefore, it is necessary to popularize the ARRIVE guidelines, advocate researchers to adhere to them in the future, and in particular promote the use of the guidelines in specialized journals in order that the design, implementation, and reporting of animal experiments is promoted, to ultimately improve their quality.

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Section: Discussionmentioning

confidence: 99%

Section: Methods Sectionmentioning

confidence: 99%

Quality of interventional animal experiments in Chinese journals: compliance with ARRIVE guidelines

et al. 2020

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“…Highly distressed laboratory animals may lead to unreliable conclusions and/or unnecessary changes in scienti c output, thereby affecting the reliability and repeatability of experiments, therefore every effort should be made to reduce unnecessary harm to them [9] . Although all countries have successively introduced laws and policies on animal welfare, and have even established animal protection organizations to supervise the regulations [19,20] , Olsson [21] and other researchers have also discussed how better to promote the issue. However, efforts on animal welfare remain unsatisfactory.…”

Section: Methods Sectionmentioning

confidence: 99%

The reporting quality of the interventional animal experiments in Chinese journals based on the evaluated results of the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines

Zhao

Jiang

Zhang

et al. 2020

Preprint

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Objective To retrospectively evaluate the reporting quality of animal experiments published in Chinese journals adhering to the Animals Research: Reporting of In Vivo Experiments (ARRIVE) guidelines. Methods The databases CNKI, WanFang, VIP, and CBM were searched from inception until July 2018. Two appropriately-trained. reviewers screened and extracted articles independently. The ARRIVE guidelines were used to assess the quality of the published reports of animal experiments. The compliance rate of every item was analyzed relative to the different dates of publication. Results A total of 4342 studies were finally included, of which 73.03% had been cited ≤ 5 times. Only 29.04% (1261/4342) were published in journals listed in the Chinese Science Citation Database. The results indicate that the compliance rate of around half of the sub-items (51.3%, 20/39) was less than 50% and 65.0% (13/20) was less than 10%. Conclusions The reporting quality of animal experiments in Chinese journals is generally at a low to moderate level. Due to the publication of the ARRIVE guidelines in 2010, the compliance rate of the majority of items in the ARRIVE guidelines has improved to some extent. However, less attention has been paid to the ethics and welfare of experimental animals, and a number of specific items in the Methods, Results, and Discussion sections continue to not be reported in sufficient detail. Therefore, it is necessary to popularize the ARRIVE guidelines, advocate researchers to adhere to them in the future, and in particular promote the use of the guidelines in specialized journals, in order that the design, implementation, and reporting of animal experiments is promoted, to ultimately improve their quality.

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“…For example, Institutional Animal Care and Use Committees in the USA are required to assess occupational health and safety considerations as part of their review of integrity of the research, which includes review of experimental design. 35 So, even if there was a health and safety approach adopted to addressing this issue, there is still reason to think that the AEC has an important role to play. The AEC is able to assess each project in detail and has the authority to prevent it from proceeding until it is satisfied that it is compliant with AEC standards, which we argue should include that potential harms to animal laboratory personnel are reduced where possible and are of an acceptable level.…”

Section: Current Controversymentioning

confidence: 99%

Animal researchers shoulder a psychological burden that animal ethics committees ought to address

King

Zohny

2021

J Med Ethics

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Animal ethics committees (AECs) typically focus on the welfare of animals used in experiments, neglecting the potential welfare impact of that animal use on the animal laboratory personnel. Some of this work, particularly the killing of animals, can impose significant psychological burdens that can diminish the well-being of laboratory animal personnel, as well as their capacity to care for animals. We propose that AECs, which regulate animal research in part on the basis of reducing harm, can and ought to require that these harms to researchers are reduced as well. The paper starts by presenting evidence of these burdens and their harm, giving some examples showing how they may be mitigated. We then argue that AECs are well placed to account for these harms to personnel and ought to use their power to reduce their occurrence. We conclude by responding to four potential objections: (1) that this problem should be addressed through health and safety administration, not research ethics administration; (2) that the proposal is unjustifiably paternalistic; (3) that these harms to laboratory animal personnel ought to occur, given their treatment of animals; and (4) that mitigating them may lead to worse treatment of research animals.

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The Role of IACUCs in Responsible Animal Research

Cited by 27 publications

References 31 publications

Quality of interventional animal experiments in Chinese journals: compliance with ARRIVE guidelines

Quality of interventional animal experiments in Chinese journals: compliance with ARRIVE guidelines

The reporting quality of the interventional animal experiments in Chinese journals based on the evaluated results of the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines

Animal researchers shoulder a psychological burden that animal ethics committees ought to address

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