The role of IL-17 rs2275913, IL-17RC rs708567 and TGFB1 rs1800469 SNPs and IL-17A serum levels in patients with lupus nephritis

Hristova, Maria; Kamenarska, Zornitsa; Dzhebir, Gyulnas; Nikolova, Svetla; Hristova, Rozalia; Mihova, Kalina; Vinkov, Anton; Georgiev, Tsvetoslav; Pozharashka, Joana; Kaneva, Radka; Savov, Alexey; Koundurdjiev, Atanas; Dourmishev, Lyubomir

doi:10.1007/s00296-021-04996-z

Cited by 11 publications

(13 citation statements)

References 31 publications

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“…Notably, disturbances in IL-17 and TGF-β levels may be driven by polymorphisms in the genes encoding these two cytokines or their receptors, which may culminate in the development of SLE (Hristova et al, 2021).…”

Section: )mentioning

confidence: 99%

Disturbance in Serum Levels of IL-17 and TGF-β1 and in Gene Expression of ROR-γt and FOX-P3 Is Associated with Pathogenicity of Systematic Lupus Erythematosus

et al. 2022

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To investigate the disturbance in serum levels of interleukin-17 (IL-17) and transforming growth factor-beta1 (TGF-β1) and gene expression of retinoic acid-related orphan receptor-gamma t (ROR-γt) and forkhead box-P3 (FOX-P3) in patients with systemic lupus erythematosus (SLE) and to study their association with disease pathogenicity and activity. Newly diagnosed active patients with SLE (n=88) and healthy volunteers (n=70) were included. Serum IL-17 and TGF-β1 were measured using enzyme-linked immunosorbent assay. Gene-expression profiles of ROR-γt and FOX-P3 were screened using real-time polymerase chain reaction. The IL-17/TGF-β1 and ROR-γt/FOX-P3 levels were also calculated. The mean age of the patients was 30.96±8.25 years; they were 82 women and 6 men. Of the patients, 11.4% manifested mild disease while 88.6% had severe disease. The serum level of TGF-β1 was significantly lower (70.2±34.9 vs. 200.23±124.77 pg/ml), while both IL-17 (614.7±317.5 vs. 279.76±110.65 pg/ml) and IL-17/TGF-β1 (18.5±30.1 vs. 1.66±0.9) levels were significantly higher, in patients than in controls (p<0.0001).The gene-expression level of FOX-P3 (0.6±0.8 vs. 13.68±39.35) was reported to be lower, while ROR-γt (3.9±3.5 vs. 1.99±2.09) and ROR-γt/FOX-P3 (18.6±21.1 vs. 7.63±17.19) levels were significantly higher, in patients than in controls (p<0.0001).

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Section: )mentioning

confidence: 99%

Disturbance in Serum Levels of IL-17 and TGF-β1 and in Gene Expression of ROR-γt and FOX-P3 Is Associated with Pathogenicity of Systematic Lupus Erythematosus

et al. 2022

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“…Our result is consistent with that of the study in the Egyptian JSLE patients [41] and in the Slavic adult SLE patients. [29] Not only lack of association of the IL17 polymorphisms with RA susceptibility was reported in case-control studies of Algerian, [22] Polish [42] and Brazilian [39] but also no significant association was observed between IL17F gene rs763780 polymorphism and OA risk in Chinese population. [43] The different results among the studies may be attributed to different age onset of the diseases and different populations.…”

Section: Discussionmentioning

confidence: 99%

“…[21] To date, the SNPs in the IL17 gene have been reported to be associated with an increased risk for different autoimmune diseases including RA, [22,23] AS, [24,25] spondyloarthritis, [26] inflammatory bowel disease [27] and adult SLE. [28,29] However, few studies were performed to investigate the role of IL17 SNPs in JIA and JSLE in a Chinese population. Hence, the influence of IL17A rs2275913 and IL17F rs763780 on JIA and JSLE were studied in our study.…”

Section: Introductionmentioning

confidence: 99%

IL12B and IL17 genes polymorphisms associated with differential susceptibility to juvenile idiopathic arthritis and juvenile-onset systemic lupus erythematosus in Chinese children

Zhang

Peng

et al. 2023

Medicine

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Genetic factors play a crucial role in the immune response of juvenile idiopathic arthritis (JIA) and juvenile-onset systemic lupus erythematosus (JSLE). This study aimed to investigate the association of IL12B (rs3212227, rs6887695) and IL17 (rs2275913, rs763780) gene polymorphisms with the susceptibility of JIA and JSLE in Chinese children. A total of 303 healthy controls and 304 patients including 160 JIA and 144 patients were analyzed, and the genetic polymorphisms were genotyped by using a Sequenom MassArray system. There was a significant association between the IL12B rs3212227 genotype and the increased risk of JSLE (P = .01). For rs6887695, the minor allele C was significantly associated with the increased risk of JIA (odds ratio = 1.48, 95% confidence interval [CI] = 1.12–1.95, P = .005). Moreover, rs6887695 genotype was significantly associated with both JIA and JSLE susceptibility (P < .05). Besides, IL12B haplotype GC significantly associated with the increased risk of JIA (P = .016). However, no significant difference was found between the IL17 (rs2275913, rs763780) gene polymorphisms and JIA or JSLE susceptibility (P > .05). And similar genotype distributions of IL12B and IL17 polymorphisms were found between the patients with nephritis and without nephritis in JSLE (P > .05). Our results indicated that IL12B polymorphisms was associated with an increased risk for the development of JIA and JSLE in Chinese children, highlighting the involvement of inflammation in the pathogenesis of JIA and JSLE. Moreover, there was a risk haplotype in IL12B which could increase the risk of JIA.

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“…Of these 350 articles, 323 were excluded due to irrelevant titles and abstracts, and 15 were excluded after reading the full-texts. Ultimately 12 articles [12,[17][18][19][20][21][22][23][24][25]27,28] with 1308 cases and 1714 controls met the inclusion criteria and the data were extracted for conducting a meta-analysis. Of the 12 studies, 7 were Caucasians, [12,17,21,23,25] 4 were Asians [18,20,22,24] and one was Latin American.…”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

The association between C509T, T869C, G915C gene polymorphisms of transforming growth factor-β1 and systemic lupus erythematosus risk: A meta-analysis

Chen

Dai

et al. 2023

Medicine

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Background: The relationship between transforming growth factor-β1 (TGF- β1) gene polymorphisms and systemic lupus erythematosus (SLE) has been reported in many studies, but there were still controversies with regard to their conclusions. Methods: Relevant documents were retrieved from 5 electronic databases such as PubMed, Embase, Cochrane Library, Wanfang, and China national knowledge infrastructure. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to assess the relationship between TGF-β1 genetic variation and SLE. Results: The present meta-analysis included 12 case-control studies with 1308 SLE patients and 1714 healthy controls. The results of the combined analyses showed that TGF-β1 C509T polymorphism showed no association with SLE risk (TC vs CC: OR = 1.16, 95% CI = 0.91–1.48, P Heterogeneity (P H) = 0.579; TT vs CC: OR = 1.15, 95% CI = 0.63–2.09, P H = 0.003; T vs C: OR = 1.08, 95% CI = 0.8–1.45, P H = 0.003; TC/TT vs CC: OR = 1.17, 95% CI = 0.93–1.46, P H = 0.133; and TT vs TC/CC: OR = 1.06, 95% CI = 0.64–1.76, P H = 0.004). TGF-β1 G915C and T869C polymorphisms were not linked with SLE risk. Moreover, subgroup analysis stratified by ethnicity and Hardy–Weinberg equilibrium revealed no significant correlation of TGF-β1 T869C, C509T, G915C polymorphisms with SLE risk. Conclusion: TGF-β1 T869C, C509T, G915C polymorphisms might not be associated with the development of SLE.

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The role of IL-17 rs2275913, IL-17RC rs708567 and TGFB1 rs1800469 SNPs and IL-17A serum levels in patients with lupus nephritis

Cited by 11 publications

References 31 publications

Disturbance in Serum Levels of IL-17 and TGF-β1 and in Gene Expression of ROR-γt and FOX-P3 Is Associated with Pathogenicity of Systematic Lupus Erythematosus

Disturbance in Serum Levels of IL-17 and TGF-β1 and in Gene Expression of ROR-γt and FOX-P3 Is Associated with Pathogenicity of Systematic Lupus Erythematosus

IL12B and IL17 genes polymorphisms associated with differential susceptibility to juvenile idiopathic arthritis and juvenile-onset systemic lupus erythematosus in Chinese children

The association between C509T, T869C, G915C gene polymorphisms of transforming growth factor-β1 and systemic lupus erythematosus risk: A meta-analysis

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