The role of IL-23/IL-17 axis in the etiopathogenesis of Behçet's disease

Leng, Rui‐Xue; Chen, Gui-Mei; Pan, Hai‐Feng; Ye, Dong-Qing

doi:10.1007/s10067-010-1531-2

Cited by 16 publications

(7 citation statements)

References 7 publications

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“…IL23 is an indispensible cytokine for the differentiation of Th17 [7,24]. These results suggest that the IL-23/IL-17 pathway may make a contribution for immunological aberrations of BD [25].…”

Section: Il-23mentioning

confidence: 70%

Role of Cytokines in Behcets Disease

Abdelmoktader¹

2017

VIJ

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Behcets disease (BD) is considered a chronic relapsing multisystem inflammatory disorder. It has a worldwide distribution, but it is more prevalent in Mediterranean countries. Although its etiopathogenesis remains elusive, Immunological investigations have demonstrated the presence of immune dysregulation among the patients with BD. The disease is characterized by infiltration of lymphocytes and neutrophils into the affected organs.the Th1 type cytokine profile is predominant in. The serum concentrations of mainly Th1 type cytokines were reported to be increased in BD and probably contribute to neutrophil and endothelial cell activation.

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Section: Il-23mentioning

confidence: 70%

Role of Cytokines in Behcets Disease

Abdelmoktader¹

2017

VIJ

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“…Other studies have shown that polymorphism in the IL-21, IL-10, and IL-8 genes and in the tumour necrosis factor-(TNF-)alpha-1031C allele are correlated with the pathogenesis of BD [6–11]. The role of the IL-23/IL-17 axis has been found to be associated with the onset of BD [12, 13]. Meanwhile, delayed-type hypersensitivity to infections such as streptococcus species (especially sanguis) has also been proposed to be an important factor in inducing BD [14].…”

Section: Discussionmentioning

confidence: 99%

Incomplete intestinal obstruction as the possible main complaint in Behcet’s disease after surgery for recurrent abdominal aortic pseudoaneurysms: a case report and literature review

Jiang

Xiang

Peng

2018

BMC Cardiovasc Disord

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BackgroundBehcet’s disease (BD) is a systemic vasculitis characterized by oral and genital aphthosis, and ocular and skin lesions. The disease is involved in vascular, gastrointestinal, and central nervous systems. Vasculitis may exacerbate fatal problems, such as anastomotic pseudoaneurysms. If the mesenteric vessels are involved, severe abdominal symptoms such as intestinal obstruction may occur.Case presentationThis case report describes a young female patient who suffered from BD with recurrent abdominal aortic pseudoaneurysms, as well as deep venous thrombosis and subsequent complications of incomplete intestinal obstruction. This patient first underwent stent grafting, which was followed by rupture of two newly formed anastomotic pseudoaneurysms within six months. Emergency open surgical repair (OSR) was then performed on the ruptured pseudoaneurysms. Thrombosis and incomplete ileus occurred five months after surgery. This case was unique due to the presence of incomplete intestinal obstruction being the possible main complaint for a patient with Behcet’s disease, and it is the first ever case to be reported.ConclusionIntestinal obstruction may present as the possible main complaint in BD. Careful and attentive strategy should be carried out to prevent fatal outcomes.

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“…In this view, we can hypothesize that various cytokine pathways are involved in the pathogenesis of the disease, including the emerging role of the IL-23/IL-17 axis (Leng et al 2010;Hamzaoui 2011;Kuchroo et al 2012). These genetically influenced cytokine profiles might modulate the induction of different effector T CD4?…”

Section: Discussionmentioning

confidence: 99%

Pathological Implications of Th1/Th2 Cytokine Genetic Variants in Behçet’s Disease: Data from a Pilot Study in a Sicilian Population

et al. 2013

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Cytokines act as pleiotropic polypeptides able to regulate inflammatory/immune responses and to provide important signals in physiological and pathological processes. Several cytokines (Th1, Th2, and Th17) seem to be involved in the pathophysiology of Behçet's disease, a chronic immune-mediated disease characterized by oral and genital lesions and ocular inflammation. Its individual susceptibility seems to be modulated by genetic variants in genes codifying these cytokines. Th1 and Th17 seem to be involved in the disease's active phases, and Th2 seems to affect the development or severity of the disease; however, contrasting data are reported. In this study, some genetic variants of the Th1/Th2 cytokine genes were investigated in Sicilian patients and age- and gender-matched controls. Three very significant associations with Behçet's disease were detected, and combined genotypes associated with increased disease risk were identified. Results obtained point to the key role of Th1/Th2 cytokine genetic variants in disease susceptibility.

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The role of IL-23/IL-17 axis in the etiopathogenesis of Behçet's disease

Cited by 16 publications

References 7 publications

Role of Cytokines in Behcets Disease

Role of Cytokines in Behcets Disease

Incomplete intestinal obstruction as the possible main complaint in Behcet’s disease after surgery for recurrent abdominal aortic pseudoaneurysms: a case report and literature review

Pathological Implications of Th1/Th2 Cytokine Genetic Variants in Behçet’s Disease: Data from a Pilot Study in a Sicilian Population

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