The role of IL-33/ST2 signaling in the tumor microenvironment and Treg immunotherapy

Lei, Shangbo; Jin, Jiamin; Zhao, Xiaohong; Zhou, Lihua; Qi, Guangying; Yang, Jinfeng

doi:10.1177/15353702221102094

Cited by 5 publications

(2 citation statements)

References 113 publications

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“…MTE inhibits osteopontin, which is elevated in human CRC, and may function as an immune checkpoint and potent T cell suppressor ( 15 ). MTE downregulates ST2, a factor that drives Tregs to accumulate in the tumor microenvironment ( 16 ), was down regulated by MTE.…”

Section: Resultsmentioning

confidence: 99%

Marsdenia tenacissima enhances immune response of tumor infiltrating T lymphocytes to colorectal cancer

Yi,

Zhang,

Yan

et al. 2023

Front. Immunol.

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IntroductionTumor-infiltrating T lymphocytes in the tumor microenvironment are critical factors influencing the prognosis and chemotherapy outcomes. As a Chinese herbal medicine, Marsdenia tenacissima extract (MTE) has been widely used to treat cancer in China. Its immunoregulatory effects on tumor-associated macrophages is well known, but whether it regulates tumor-infiltrating T-cell functions remains unclear.MethodWe collected 17 tumor samples from MTE-administered colorectal cancer patients, 13 of which showed upregulation of CD3+/CD8+ tumor-infiltrating T cells. Further in vitro and in vivo experiments were performed to investigate the regulatory effects of MTE on tumor-infiltrating T cells and immune escape of tumors.ResultsUnder single and co-culture conditions, MTE inhibited TGF-β1 and PD-L1 expression in the colorectal cancer (CRC) cell lines HCT116 and LoVo. In Jurkat cells, MTE inhibited FOXP3 and IL-10 expression, increased IL-2 expression, but had no effect on PD-1 expression. These findings were confirmed in vitro using subcutaneous and colitis-associated CRC mouse models. MTE also increased the density of CD3+/CD8+ tumor-infiltrating T cells and exhibited considerable tumor-suppressive effects in these two tumor mouse models.ConclusionsOur findings suggested that MTE inhibits the immune escape of cancer cells, a precipitating factor increasing the immune response of T lymphocytes.

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Section: Resultsmentioning

confidence: 99%

Marsdenia tenacissima enhances immune response of tumor infiltrating T lymphocytes to colorectal cancer

Yi,

Zhang,

Yan

et al. 2023

Front. Immunol.

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“…IL-33, present in the nucleus as a nuclear factor, is rapidly released during cell stress or damage (122). IL-33, in combination with ST2, induces the production of inflammatory factors by DC, macrophages, Th2, Tregs, mast cells, and innate lymphoid cell type 2 (ILC2) (123,124), promotes the proliferation of Tregs and enhances the inhibitory capacity of Tregs (125,126).…”

Section: Th17 and Treg Differentiation And Function In The Sepsismentioning

confidence: 99%

Th17/Treg balance: the bloom and wane in the pathophysiology of sepsis

Liu,

Chen,

Peng

et al. 2024

Front. Immunol.

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Sepsis is a multi-organ dysfunction characterized by an unregulated host response to infection. It is associated with high morbidity, rapid disease progression, and high mortality. Current therapies mainly focus on symptomatic treatment, such as blood volume supplementation and antibiotic use, but their effectiveness is limited. Th17/Treg balance, based on its inflammatory property, plays a crucial role in determining the direction of the inflammatory response and the regression of organ damage in sepsis patients. This review provides a summary of the changes in T-helper (Th) 17 cell and regulatory T (Treg) cell differentiation and function during sepsis, the heterogeneity of Th17/Treg balance in the inflammatory response, and the relationship between Th17/Treg balance and organ damage. Th17/Treg balance exerts significant control over the bloom and wanes in host inflammatory response throughout sepsis.

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