The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6 -174GC, IL-8 -251AT and MCP-1 -2518AG in the risk of venous thromboembolism: A case-control study

Matos, Marinez Farana; Lourenço, Dayse Maria; Orikaza, Cristina Mary; Bajerl, João Alexandre Hool; Noguti, Maria Aparecida Eiko; Morelli, Vânia M.

doi:10.1016/j.thromres.2011.04.016

Cited by 76 publications

(61 citation statements)

References 30 publications

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“…Moreover, the metabolic syndrome -abdominal obesity, insulin resistance, arterial hypertension, hypertriglyceridemia, low HDL (high density lipoprotein) cholesterol -an important risk factor of the atherosclerotic disease, has been recently associated with venous thromboembolism [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Inflammation -The Connection Between Arterial and Venous Thrmentioning

confidence: 99%

“…Patients with primary venous thrombotic events have significantly higher prevalence of carotid plaques, carotid intima-media thickness and number of carotid segments affected compared with those with secondary events of same sex and age and case control patients with no thrombosis. In patients with idiopathic venous thrombosis, endothelial dysfunction has also been noticed [1,15].…”

Section: Inflammation -The Connection Between Arterial and Venous Thrmentioning

confidence: 99%

“…A 50% reduction of venous thromboembolism risk has been associated with the use of statins [1,15,16]. The LDL (low density lipoprotein) cholesterol levels did not influence thromboembolic risk, therefore the protective effect of statins may be due to their pleiotropic, antithrombotic and anti-inflammatory properties [15] and improvement in blood rheological properties [1]. It has also been demonstrated that the risk of venous thromboembolism in patients with clinical coronary heart disease is lowered by long term aspirin treatment [1,17].…”

Section: Inflammation -The Connection Between Arterial and Venous Thrmentioning

confidence: 99%

“…Thus, the formation of thrombus promotes the inflammatory response, which subsequently, stimulates the pro-thrombotic factors. These affirmations are supported by the fact that thrombosis can be prevented by natural anticoagulants, such as protein C and S, antithrombin III, which can also reduce inflammatory activity [1,2,15,[19][20][21].…”

Section: Interaction Between Inflammation and Thrombosismentioning

confidence: 99%

“…An increase in the inflammatory markers, which might reflect an independent inflammatory pro-cess or a subclinical persistent inflammation, may be secondary to other diseases associated with venous thrombosis, such as post-thrombotic syndrome or occult cancer. [15,17,[19][20][21].…”

Section: Interaction Between Inflammation and Thrombosismentioning

confidence: 99%

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Involvement of inflammatory markers in pathogenesis of venous thromboembolism

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et al. 2017

Revista Romana De Medicina De Laborator

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Inflammation of the venous wall is involved in thrombogenesis, thrombus resolution, wall remodeling and the post-thrombotic syndrome. Different mechanisms are involved in both arterial and venous thrombosis and patients with atherothrombosis hold a higher risk of venous thrombosis. Although inflammation may represent the connection between arterial and venous thrombosis, it is not yet sure if it is the cause or consequence of venous thrombosis. Consequently, the relationships between inflammation markers as indicators of the inflammatory process and clinical venous thromboembolism need to be investigatd. For example, inflammation mediators such as the pro-inflammatory cytokines interleukin 8 (IL-8), IL-6, monocyte chemotactic protein 1 (MCP-1), C Reactive Protein (CRP), vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), matrix metalloproteinases and tumor necrosis factor alpha (TNF alpha)

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