The role of illicit drugs in developing medication-related osteonecrosis (MRONJ): a systematic review

Abstract

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Impact of licit and illicit substances on the oral health‐related quality of life in adolescents

“…According to the 3rd Brazilian National Survey of Scholar Health, conducted in 2015, the percentage of alcohol, tobacco, and illicit drug use reached values of 72.1%, 26%, and 14.3% for adolescents and young adults, respectively (Bastos et al, 2017). Recent systematic reviews have shown that this consumption has the potential to increase the development of oral diseases, such as dental caries, periodontitis, dental trauma, cancer, and other oral pathologies (Jiang et al, 2019; Magno et al, 2019; Pesce et al, 2022; Sacco et al, 2021). Biologically, nicotine can impair the host's protective response against the bacterial biofilm, producing increased cytokines, inflammatory enzymes, and a higher adhesion of Streptococcus Mutans to bacterial plaque (Chanea & Palmire, 2014; Pesce et al, 2022).…”

“…Biologically, nicotine can impair the host's protective response against the bacterial biofilm, producing increased cytokines, inflammatory enzymes, and a higher adhesion of Streptococcus Mutans to bacterial plaque (Chanea & Palmire, 2014; Pesce et al, 2022). In addition, licit and illicit substances are contributors to the development of intraoral lesions through frequent pH changes and the presence of toxic and irritating substances (Jiang et al, 2019; Sacco et al, 2021).…”

“…pathologies (Jiang et al, 2019;Magno et al, 2019;Pesce et al, 2022;Sacco et al, 2021). Biologically, nicotine can impair the host's protective response against the bacterial biofilm, producing increased cytokines, inflammatory enzymes, and a higher adhesion of Streptococcus Mutans to bacterial plaque (Chanea & Palmire, 2014;Pesce et al, 2022).…”

18 Years of Medication-Related Osteonecrosis of the Jaw (MRONJ) Research: Where Are We Now?—An Umbrella Review

“…Since the first clinical study of bisphosphonate-related osteonecrosis of the jaw (BRONJ) was published in 2003, a growing number of scientific articles have documented similar complications connected with other medications, such as monoclonal antibodies, tumor necrosis factor-α (TNF-α) inhibitors drugs and recreational drugs [5][6][7]. Due to the number of medications linked with the development of ONJ, in a 2014 positional paper, the American Association of Oral and Maxillofacial Surgeons (AAOMS) developed and defined the medical term MRONJ [8].…”