2018
DOI: 10.3892/ol.2018.7763
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The role of immune cell subpopulations in the growth and rejection of TC‑1/A9 tumors in novel mouse strains differing in the H2‑D haplotype and NKC domain

Abstract: The present study aimed to elucidate the role of cluster of differentiation (CD)8+, CD4+, natural killer (NK), and myeloid (CD11b+) cells in the course of the growth and rejection of experimental major histocompatibility complex (MHC) class I-deficient, HPV16 E6/E7-associated TC-1/A9 tumors in mice. Stable mouse lines (F30) generated by inbreeding of Balb/c and C57BL/6 strains, which were characterized by H-2Db+d-NK1.1neg (B6-neg) and H-2Db-d+NK1.1high (Balb-high) phenotypes, were used for the present study. T… Show more

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Cited by 1 publication
(2 citation statements)
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“…Two hundred and nine publications used an in vivo approach to deplete CD4 + cells in a mouse model, of which 145 used anti-CD4 Ab injection regimens. Of these, 137 manuscripts attempted to deplete CD4 + T cells only, whereas just seven manuscripts acknowledged that any CD4 + cells could have been affected by this methodology (26)(27)(28)(29)(30)(31)(32). More than 80% of all published work performing anti-CD4 Ab-mediated depletion method used GK1.5.…”
Section: Most Scientific Publications Reporting the Usage Of Anti-cd4mentioning
confidence: 99%
See 1 more Smart Citation
“…Two hundred and nine publications used an in vivo approach to deplete CD4 + cells in a mouse model, of which 145 used anti-CD4 Ab injection regimens. Of these, 137 manuscripts attempted to deplete CD4 + T cells only, whereas just seven manuscripts acknowledged that any CD4 + cells could have been affected by this methodology (26)(27)(28)(29)(30)(31)(32). More than 80% of all published work performing anti-CD4 Ab-mediated depletion method used GK1.5.…”
Section: Most Scientific Publications Reporting the Usage Of Anti-cd4mentioning
confidence: 99%
“…Similarly, of the 809 manuscripts found on CD8 depletion, 801 manuscripts had English full texts available, and 185 papers performed anti-CD8 Ab-mediated depletion of CD8 + cells in vivo. Six articles stated that any CD8-expressing cells could have been affected (27,29,30,(33)(34)(35), whereas 178 papers did not comment on cells other than T cells. Diverse clones of anti-CD8a and anti-CD8b Abs were used, with anti-CD8a Ab clones 2.43 and 53-6.7 being the most common choices (Fig.…”
Section: Most Scientific Publications Reporting the Usage Of Anti-cd4mentioning
confidence: 99%