The role of immune cells in pulmonary hypertension: Focusing on macrophages

Luo, Ping; Qiu, Bing

doi:10.1016/j.humimm.2021.11.006

Cited by 13 publications

(6 citation statements)

References 143 publications

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“…The CB-7 exposure would eventually induce severe inflammation outcomes and compromise the immune balance in the lung. Notably, the alterations of the immune balance in the lung have been proposed as reasons for various diseases, such as COPD, acute lung injury, and pulmonary hypertension, as documented [54][55][56]. Thus, these results unraveled a previously unrecognized role of surface properties in determining cytotoxicity, that is, the alterations in surface O-functionalities after the ageing process can alter the interaction patterns of particles with macrophages, and then change the cytotoxicity and the immune balance in the lung, as illustrated in Figure 7.…”

Section: Resultsmentioning

confidence: 99%

Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages

Chen

et al. 2022

Antioxidants

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There are still significant concerns about the detrimental effects and health risks of particulate matters (PMs) on the respiratory system. Notably, a largely overlooked knowledge gap is whether the environmental ageing process would change the physicochemical properties of PMs as well as the toxic influences of PMs on macrophages. Here, we applied ambient treatment of model PMs to mimic the real O3-induced ageing process and investigated ageing-determined cytotoxicity profile changes of PMs towards macrophages. The consequent distinct bioreactivity and toxicity towards macrophages are largely attributed to the changes of species of surface O-functional groups. Importantly, we unveiled the specific interactions between aged PMs and macrophages due to the variant contents of the surface carboxyl group, resulting in the divergent inflammatory activations and immune balance in the lung. Collectively, this study unearths the significance of ageing in altering particle cytotoxicity, and also provides additional understandings for consecutive investigations on the adverse effects of air pollution on the respiratory system.

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Section: Resultsmentioning

confidence: 99%

Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages

Chen

et al. 2022

Antioxidants

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“…Pulmonary inflammation mediated by macrophages surrounding pulmonary vessels is a critical driving factor for pulmonary vascular remodeling. Macrophages, in different microenvironments, can be polarized into M1 or M2 type, hence influencing pulmonary hypertension progression [ 37 ]. In the PAH rat model elicited by monocrotaline (MCT), M1 macrophages can step up endothelial cell apoptosis to take part in the early stage of inflammation, and M2 macrophages can boost endothelial cell and smooth muscle proliferation to participate in inflammation repair and the following remodeling stage of abnormal tissues [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Exosomal miR-663b from “M1” macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis

et al. 2023

Aging

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Background: Inflammatory mediators from macrophages are proven to be involved in pulmonary vascular remodeling in pulmonary hypertension (PH). Here, this study intends to explore the mechanism of “M1” macrophage-derived exosomal miR-663b in pulmonary artery smooth muscle cells (PASMCs) dysfunctions and pulmonary hypertension. Methods: Hypoxia-treated PASMCs were utilized for constructing an in-vitro pulmonary hypertension model. THP-1 cells were treated with PMA (320 nM) and LPS (10 μg/mL) + IFN-γ (20 ng/ml) for eliciting macrophage “M1” polarization. Exosomes derived from “M1” macrophages were isolated and added into PASMCs. The proliferation, inflammation, oxidative stress, and migration of PASMCs were evaluated. RT-PCR or Western blot examined the levels of miR-663b and the AMPK/Sirt1 pathway. Dual luciferase activity assay and RNA pull-down assay were carried out for confirming the targeted association between miR-663b and AMPK. An in-vivo PH model was built. Macrophage-derived exosomes with miR-663b inhibition were used for treating the rats, and alterations of pulmonary histopathology were monitored. Results: miR-663b was obviously up-regulated in hypoxia-elicited PASMCs and M1 macrophages. miR-663b overexpression boosted hypoxia-induced proliferation, inflammation, oxidative stress, and migration in PASMCs, whereas miR-663b low expression resulted in the opposite situation. AMPK was identified as a target of miR-663b, and miR-663b overexpression curbed the AMPK/Sirt1 pathway. AMPK activation ameliorated the damaging impact of miR-663b overexpression and “M1” macrophage exosomes on PASMCs. In vivo , “M1” macrophage exosomes with miR-663b low expression alleviated pulmonary vascular remodeling in pulmonary hypertension rats. Conclusion: Exosomal miR-663b from “M1” macrophage facilitates PASMC dysfunctions and PH development by dampening the AMPK/Sirt1 axis.

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“…Macrophages are phenotypically heterogeneous in which M1-and M2-type macrophages bear different features and functions (Stöger et al, 2012). A significant decrease of M2 macrophage markers and a marked increase of M1 macrophage markers play a pivotal role in hypertensive remodeling through numerous molecular mechanisms (Luo and Qiu, 2022), indicating that the pro-inflammatory status of macrophages drives the pathogenesis of hypertensive vascular remodeling. It is not surprising that curcumin could regulate macrophage functions in chronic inflammatory diseases (Mohammadi et al, 2019).…”

Section: Curcumin Provides Vascular Protection In Arterial Hypertensi...mentioning

confidence: 99%

Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension?

Wang

Machuki

et al. 2022

Front. Physiol.

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Growing evidence suggests that hypertension is one of the leading causes of cardiovascular morbidity and mortality since uncontrolled high blood pressure increases the risk of myocardial infarction, aortic dissection, hemorrhagic stroke, and chronic kidney disease. Impaired vascular homeostasis plays a critical role in the development of hypertension-induced vascular remodeling. Abnormal behaviors of vascular cells are not only a pathological hallmark of hypertensive vascular remodeling, but also an important pathological basis for maintaining reduced vascular compliance in hypertension. Targeting vascular remodeling represents a novel therapeutic approach in hypertension and its cardiovascular complications. Phytochemicals are emerging as candidates with therapeutic effects on numerous pathologies, including hypertension. An increasing number of studies have found that curcumin, a polyphenolic compound derived from dietary spice turmeric, holds a broad spectrum of pharmacological actions, such as antiplatelet, anticancer, anti-inflammatory, antioxidant, and antiangiogenic effects. Curcumin has been shown to prevent or treat vascular remodeling in hypertensive rodents by modulating various signaling pathways. In the present review, we attempt to focus on the current findings and molecular mechanisms of curcumin in the treatment of hypertensive vascular remodeling. In particular, adverse and inconsistent effects of curcumin, as well as some favorable pharmacokinetics or pharmacodynamics profiles in arterial hypertension will be discussed. Moreover, the recent progress in the preparation of nano-curcumins and their therapeutic potential in hypertension will be briefly recapped. The future research directions and challenges of curcumin in hypertension-related vascular remodeling are also proposed. It is foreseeable that curcumin is likely to be a therapeutic agent for hypertension and vascular remodeling going forwards.

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The role of immune cells in pulmonary hypertension: Focusing on macrophages

Cited by 13 publications

References 143 publications

Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages

Ageing Significantly Alters the Physicochemical Properties and Associated Cytotoxicity Profiles of Ultrafine Particulate Matters towards Macrophages

Exosomal miR-663b from “M1” macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis

Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension?

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