The role of immune-related myeloid cells in angiogenesis

Local Delivery of VEGF and SDF Enhances Endothelial Progenitor Cell Recruitment and Resultant Recovery from Ischemia

“…CAC accumulation in nonischemic limbs led to a significant and multiplicative effect on the infiltration of inflammatory cells, which may subsequently secrete a variety of cytokines that can help repair and restore damaged tissues. 42,43,[47][48][49] In SCID mice, the inflammatory response is diminished, which in this model potentially limited the observed therapeutic benefit from these associated cells. Overall, the ability of CACs to accumulate in greater numbers, secrete more potent angiogenic factors, and influence behaviors of other cell types at early time points could together enhance the formation of a stable vascular network over time, and explain why CACs demonstrated a significant long-term therapeutic effect compared with OECs.…”

In vivo analysis of the time and spatial activation pattern of microglia in the retina following laser-induced choroidal neovascularization

“…However, the functional phenotype of macrophages seems to be more important than their origin. The functional phenotyping of macrophages has gained more and more attention in the analysis of patho-mechanisms in the retina and has overcome the classic M1/M2 classification (Chambers et al, 2013;Murray et al, 2014). Recent data suggest that activation of microglia cells in the retina might play a central role in the coordination of pathological events including neovascularization (Eter et al, 2008).…”

Stroma as an Active Player in the Development of the Tumor Microenvironment

“…While M1 macrophages help eliminate the pathologic insult, M2 macrophages allow tissue recovery from acute inflammatory responses and reconstruction of tissue integrity by ECM remodeling (e.g. pro-angiogeneic activities, cytokine and enzyme release) [16][17][18][19].…”