The Role of Immunologic Aberrations in the Pathogenesis of Lymphoma

Bierman, Stanley M.

doi:10.1001/archderm.1968.01610120089014

Cited by 9 publications

(2 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lymphomas have been noted to occur with increased frequency in patients with adult celiac disease, nontropical sprue, chronic steatorrhea, Sjögren's syndrome, and other conditions. [18][19][20][21][22][23] There have been also several cases reported of malignant lymphoma developing in patients with Hashimoto's thyroiditis, 23 as in our patient. This entity may be involved in the development of MALToma of the duodenum, but the rarity of the disease has not allowed the precise identification of such factors.…”

Section: Discussionmentioning

confidence: 69%

Lymphoma arising in mucosa-associated lymphoid tissue of the duodenal bulb

Kawai¹,

Tada

Yokoyama

et al. 1998

Journal of Gastroenterology

View full text Add to dashboard Cite

We report a case of low-grade B-cell lymphoma of the duodenal bulb arising from mucosa-associated lymphoid tissue. A barium swallow and an endoscopic examination showed multiple elevated, irregularly contoured lesions limited to the duodenal bulb. Endoscopic biopsy specimens were highly suggestive of non-Hodgkin's lymphoma. The resected specimen showed a gyriform mucosal elevation measuring 3 x 2cm in extent, with multiple small polypoid elevations scattered around it. Histologically, the small lymphocytes constituting the tumor infiltrated the duodenal mucosa and submucosa. The neoplastic centrocyte-like cells tended to grow around reactive lymphoid follicles and to invade epithelial structures, forming characteristic lymphoepithelial lesions. Monoclonal proliferation of the lymphoid tissue was demonstrated by the polymerase chain reaction method. The histologic appearance and the demonstration of monoclonality fulfilled the criteria for malignant lymphoma arising from mucosa-associated lymphoid tissue, which is extremely rare in the duodenum.

show abstract

Section: Discussionmentioning

confidence: 69%

Lymphoma arising in mucosa-associated lymphoid tissue of the duodenal bulb

Kawai¹,

Tada

Yokoyama

et al. 1998

Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…Lymphoreticular neoplasms occur significantly more often in patients with immunodeficiency diseases, as, for instance, Swiss type agammaglobulinaemia, Bruton's disease, ataxia teleangiectatica, and the Wiscott-Aldrich syndrome (Wall and Saslaw, 1955;Page, Hansen, and Good, 1963;Peterson, Cooper, and Good, 1965;ten Bensel, Stadlan, and Krivit, 1966;Goldman, Haggard, McFadden, Ritzmann, Houston, Bratcher, Weiss, Box, and Szekrenyes, 1967;Bierman, 1968) which in turn are associated with sprue and intestinal atrophy (Sanford, Favour, and Tribeman, 1954;Rosecan, Trobaugh, and Danforth, 1955;Wall and Saslaw, 1955). The increased incidence of Giardia lamblia infection in these cases is probably related to a reduced local immunity rather than being the cause of the sprue (McGrath, O'Farrell, and Boland, 1940;Hermans et al, 1966).…”

Section: Discussionmentioning

confidence: 99%

Intestinal lymphoma and sprue: A systematic approach

Dutz¹,

Asvadi²,

Sadri³

et al. 1971

Gut

View full text Add to dashboard Cite

SUMMARY Intestinal lymphoma is frequently associated with sprue-like bowel patterns. A standardized approach to the problem is suggested.Intestinal lymphoma has been subdivided into four groups, depending on the extent of involvement of the anatomical region. Only cases with specific lesions are accepted as primary lymphoma.The villous pattern in 179 cases at necropsy with suitably preserved mucosa was determined to form a normal baseline for comparison with the uninvolved portions of the lymphomatous small bowel. Only 15 % of all small bowel of this random material of children more than 1 year old and adults showed a flattened mucosa.The non-lymphomatous mucosa of 20 cases with definitely primary intestinal reticulum or lymphosarcoma showed severe sprue-like atrophy in 18 (90%). Two cases of intestinal Hodgkin's disease and four cases of gastric lymphoma were associated with regular mucosal patterns.It is concluded that sprue-like villous atrophy of the small bowel is definitely a triggering factor for the development of primary intestinal reticulum cell or lymphosarcoma. A hypothesis for the possible aetiological relationship of these two conditions is discussed.

show abstract

Chronic malabsorption (steatorrhea, n-ontropical sprue) in an adolescent, with death from malignant lymphoma, histiocytic type (reticulum cell sarcoma)

Huntington

Larwood

Armstrong

et al. 1970

Cancer

View full text Add to dashboard Cite

The association of intestinal malabsorption with lymphoma is both more frequent and more mysterious than is generally realized. Cases of malabsorption with eventual emergence of lymphoma often are initially responsive to dietary treatment, and it may be exceedingly difficult to decide whether the malabsorption or the lymphoma comes first. These problems are illustrated by the case of an 18‐year‐old Mexican girl whose malabsorption initially responded well to dietary management. When lymphoma was first suspected, evaluation of the first biopsy material was very difficult. Although most consultants agreed that there was malignancy amid reactive hyperplasia, there was a variety of opinions as to the character of the malignancy. Later on, the pattern became clearly that of histiocytic lymphoma (reticulum cell sarcoma).

show abstract

The Role of Immunologic Aberrations in the Pathogenesis of Lymphoma

Cited by 9 publications

References 71 publications

Lymphoma arising in mucosa-associated lymphoid tissue of the duodenal bulb

Lymphoma arising in mucosa-associated lymphoid tissue of the duodenal bulb

Intestinal lymphoma and sprue: A systematic approach

Chronic malabsorption (steatorrhea, n-ontropical sprue) in an adolescent, with death from malignant lymphoma, histiocytic type (reticulum cell sarcoma)

Contact Info

Product

Resources

About