The Role of Immunotherapy and Biologic Treatments in Occupational Allergic Disease

Smith, Andrew M.; Sastre, Joaquı́n

doi:10.1016/j.jaip.2020.07.042

Cited by 6 publications

(3 citation statements)

References 58 publications

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“…Pharmacologic treatment of OA is similar to that of nonoccupational asthma. Cases of OA caused by latex, flour, or laboratory animals have been successfully treated with immunotherapy [40]. Omalizumab, a monoclonal antibody targeting IgE, has been shown to be effective in reducing asthma exacerbations and improving asthma control in patients with persistent exposure to their offending agent.…”

Section: Managementmentioning

confidence: 99%

“…Omalizumab, a monoclonal antibody targeting IgE, has been shown to be effective in reducing asthma exacerbations and improving asthma control in patients with persistent exposure to their offending agent. Since a significant proportion of patient with OA have a severe disease, some of them may also be candidates to receive other biologic treatments such as interleukin (IL)-5/IL-5R antagonists, anti-IL-4R or anti-TLSP [40]. However, the effectiveness of biologic therapies in OA needs to be confirmed by studies designed to answer this question.…”

Section: Managementmentioning

confidence: 99%

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Recent developments in occupational asthma

Blouin,

Lemière

2024

Current Opinion in Pulmonary Medicine

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Purpose of this review Occupational asthma (OA) is a complex condition that can be difficult to diagnose. The purpose of this review is to describe some recent findings regarding the epidemiology of OA, the occupational sensitizing agents, the prognosis of OA, and its primary prevention. Recent findings The risk of developing OA varies according to the geographic localization of the worker, the type of industry and the type of sensitizing agents. New findings have been reported for several known sensitizing agents, such as isocyanates, seafood & cleaning agents, and their related industries, such as hairdressing salons and schools. Moreover, a few new sensitizing agents, such as cannabis, have been identified in the past few years. The prognosis of OA seems worse than that of nonwork-related asthma. It is mainly determined by the duration and the level of exposure. Primary prevention is crucial to reduce the number of new cases of OA. Complete avoidance of exposure to the causal agent remains the optimal treatment of sensitizer-induced OA. Summary Improving our knowledge regarding OA and its causative agents is key to enable an early recognition of this condition and improve its prognosis. Further research is still needed to improve primary prevention.

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Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Recent developments in occupational asthma

Blouin,

Lemière

2024

Current Opinion in Pulmonary Medicine

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“…In certain settings, workers with OA may choose to continue working in jobs with reduced allergen exposures where it cannot be totally eliminated. A review that included three studies involving foods (all used wheat flour) concluded that there was increasing but modest evidence of beneficial short- and long-term effects of immunotherapy and safety in worker populations [58]. Dubini et al also reported on the success of sublingual specific immunotherapy (SLIT) for baker's asthma and rhinitis [59].…”

Section: Preventionmentioning

confidence: 99%

Occupational inhalant allergy in food handling occupations

Jeebhay

Baatjies

2021

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewReview article on recent developments on inhalant food allergens associated with occupational respiratory allergy and asthma. Recent findingsThis review has found that occupational inhalant allergy in food handling occupations is a common and recognisable clinical entity (class 3 food allergy) in high-risk food occupations such as bakeries and seafood processing. Aerosolised food proteins from plant or animal food sources, additives and biological food contaminants cause occupational sensitization, rhinitis and asthma. The risk of allergy may be enhanced across the food value chain as a result of food processing techniques including the introduction of new food allergens in the food matrix. Occupational food allergy and asthma can be prevented by improved health-based exposure standards, workplace control measures, education and training activities, and early diagnosis accompanied with exposure reduction. SummaryFuture studies need to focus on exposure-response studies to establish improved exposure limits especially for flour dust, the relevance of cooked vs raw foods in influencing risk, identifying and characterising major inhalant food allergens accompanied with component resolved diagnostic approaches, and evaluating the effectiveness of interventions for common high-risk food sensitizers causing occupational rhinitis and asthma.

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Occupational food allergy

Hamzavi-Abedi

Ponda

2024

Encyclopedia of Food Allergy

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The Role of Immunotherapy and Biologic Treatments in Occupational Allergic Disease

Cited by 6 publications

References 58 publications

Recent developments in occupational asthma

Recent developments in occupational asthma

Occupational inhalant allergy in food handling occupations

Occupational food allergy

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