The role of immunotherapy in in vitro fertilization and recurrent pregnancy loss: a systematic review and meta-analysis

Achilli, Chiara; Durán-Retamal, Montserrat; Saab, Wael; Serhal, Paul; Seshadri, Srividya

doi:10.1016/j.fertnstert.2018.07.004

Cited by 88 publications

(62 citation statements)

References 81 publications

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“…A Cochrane review of immunotherapy for recurrent miscarriage reporting the analysis of 20 high quality trials concluded that neither paternal cell immunization, third-party donor leukocytes, trophoblast membranes, or intravenous immunoglobulin provided any significant beneficial effect over placebo in improving the live birth rate (55). A more recent meta-analysis of the role of immunotherapy in IVF and RPL reviewed 30 studies meeting the selection criteria and led to the conclusion that the study did not show a role for immunotherapy in improving the live birth rate in women undergoing IVF treatment or in the prevention of idiopathic RPL (56). This conclusion is consistent with that of the recent Practice Committee of the ASRM guideline addressing the routine use of immunotherapies in the context of IVF (19).…”

Section: Treating Immunologic Aspects Of Recurrent Pregnancy Losssupporting

confidence: 57%

Immunologic and rheumatologic causes and treatment of recurrent pregnancy loss: what is the evidence?

Odendaal

Quenby

Sammaritano

et al. 2019

Fertility and Sterility

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Section: Treating Immunologic Aspects Of Recurrent Pregnancy Losssupporting

confidence: 57%

Immunologic and rheumatologic causes and treatment of recurrent pregnancy loss: what is the evidence?

Odendaal

Quenby

Sammaritano

et al. 2019

Fertility and Sterility

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“…The intrauterine administration of corticotropin-releasing hormone (CRH)-treated autologous PBMCs was also demonstrated to improve clinical pregnancy rates of patients with repeated implantation failure [154]. Currently, the effectiveness of PBMC therapy has been positively reported [155][156][157][158].…”

Section: Topics Of Clinical Application Of Immune Therapymentioning

confidence: 99%

Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

Fujiwara

Ono

Sato

et al. 2020

IJMS

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Embryo implantation in the uterus is an essential process for successful pregnancy in mammals. In general, the endocrine system induces sufficient embryo receptivity in the endometrium, where adhesion-promoting molecules increase and adhesion-inhibitory molecules decrease. Although the precise mechanisms remain unknown, it is widely accepted that maternal–embryo communications, including embryonic signals, improve the receptive ability of the sex steroid hormone-primed endometrium. The embryo may utilize repulsive forces produced by an Eph–ephrin system for its timely attachment to and subsequent invasion through the endometrial epithelial layer. Importantly, the embryonic signals are considered to act on maternal immune cells to induce immune tolerance. They also elicit local inflammation that promotes endometrial differentiation and maternal tissue remodeling during embryo implantation and placentation. Additional clarification of the immune control mechanisms by embryonic signals, such as human chorionic gonadotropin, pre-implantation factor, zona pellucida degradation products, and laeverin, will aid in the further development of immunotherapy to minimize implantation failure in the future.

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“…Recently, immunomodulatory drugs including steroids [117,118], intravenous immnunoglobulins [119], TNF-a antagonist [120], granulocyte colony-stimulating factor (G-CSF) agonist [121], and intravenous intralipids [122] also have been attempted for treatment of recurrent pregnancy loss and recurrent implantation failure (reviewed in [123]). The effects of these treatments are controversial [124].…”

Section: Miscarriage and Infertilitymentioning

confidence: 99%

Harmful and beneficial effects of inflammatory response on reproduction: sterile and pathogen-associated inflammation

Negishi

Shima

Takeshita

et al. 2020

Immunological Medicine

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In reproduction, inflammatory processes play important roles in the development of many pregnancy complications such as preterm labor/birth, recurrent pregnancy loss, recurrent implantation failure, and preeclampsia. Inflammation can be initiated by both microbial and non-microbial causes. Bacterial infection in the feto-maternal interface and uterus can provoke preterm labor/birth, miscarriage, and chronic endometritis. By contrast, inflammation without infection, or 'sterile inflammation,' can also lead to many kinds of complications, such as preterm labor/birth, miscarriage, or preeclampsia. Aberrant inflammation is facilitated by immune cells such as macrophages, dendritic cells, natural killer cells, and invariant natural killer T cells. In addition, cytokines, chemokines, and several kinds of inflammatory mediators are involved. On the other hand, appropriate inflammation is required for a successful offspring during the progression of the entire pregnancy. Herein, we discuss the relation between pregnancy and inflammation with immunological alterations. Understanding the role of inflammation in complications during pregnancy may establish new perspectives of the progress of normal pregnancy as well as treatments during pregnancy complications.

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The role of immunotherapy in in vitro fertilization and recurrent pregnancy loss: a systematic review and meta-analysis

Cited by 88 publications

References 81 publications

Immunologic and rheumatologic causes and treatment of recurrent pregnancy loss: what is the evidence?

Immunologic and rheumatologic causes and treatment of recurrent pregnancy loss: what is the evidence?

Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

Harmful and beneficial effects of inflammatory response on reproduction: sterile and pathogen-associated inflammation

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