The role of incretin as an integrator of sodium and water balance regulation

Natochin, Yu. V.; Marina, A. S.; Kutina, A. V.

doi:10.1134/s0012496614050044

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Recently, it was shown in rats that injection of GLP-1 mimetic exenatide could enhance urinary sodium excretion following i.p. NaCl load (12). In the present study, it was demonstrated that the blood concentration of incretin hormone, GLP-1, was previously elevated within 5 min after oral salt consumption.…”

Section: Discussionsupporting

confidence: 58%

“…GLP‐1 enhances glucose‐stimulated insulin secretion and exerts multiple non‐insulinotropic actions . Our previous studies demonstrated that, under hypernatraemia, GLP‐1 mimetic promoted urinary sodium excretion . The co‐influence of these two hormones (vasopressin and GLP‐1) could induce altered natriuretic effect because of the different sites of action in the nephron: GLP‐1 inhibits reabsorption of tubular fluid in the proximal segment of the nephron and vasopressin modifies solutes reabsorption in the distal nephron and collecting ducts .…”

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confidence: 99%

“…The effect of activation of V 1a receptors in the hyperosmolar state is not well understood and requires special investigation. Recent studies have shown that the physiological mechanisms of osmotic homeostasis could involve not only vasopressin, but also gastrointestinal hormone glucagon‐like peptide‐1 (GLP‐1) . GLP‐1 enhances glucose‐stimulated insulin secretion and exerts multiple non‐insulinotropic actions .…”

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confidence: 99%

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Role of Vasopressin in the Regulation of Renal Sodium Excretion: Interaction with Glucagon‐Like Peptide‐1

Kutina

Golosova

Marina

et al. 2016

J Neuroendocrinology

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Introduction: Dulaglutide (Trulicity â) is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist indicated in adults with type 2 diabetes mellitus. Data about the safety profile of dulaglutide are lacking due to the lack of experience with this recently marketed drug. Material and methods: We report the first case of a beneficial effect of dulaglu-tide. Results: A 48-year-old woman with hypertension, cardiac insufficiency and depression was treated with amlodipine, valsartan, spironolactone, nebivolol, atorvastatine, esomeprazole, escitalopram, oxazepam and tramadol. She had lower limb edema since a lot of months. For diabetes mellitus, dulaglutide (1.5 mg once a week) was started and the lower limb edema began to improve. Three months later, the lower limb edema has disappeared without any new treatment. The dulaglutide had to be interrupted for 2 months and edema recurred. The use of hydrochlorothiazide (25 mg/day) had no effect but the lower limb edema disappeared again after dulaglutide was resumed while all the other drugs were maintained. Discussion/Conclusion: The temporal relationship between dulaglutide treatment and regression of the edema is in favour of the role of dulaglutide and the role of the other drugs, continuously maintained, is ruled out. No regression of edema had been previously reported with dulaglutide. However, animal studies suggest that GLP-1 or its agonists have diuretic and natriuretic effects, which are mediated by an increase in renal plasma flow and glomerular filtration rate, as well as a decrease in the proximal reabsorption of sodium with an increase in fractional sodium excretion [1,2]. Moreover, GLP-1 reduced Na + /H + exchanger isoform 3 (NHE3)-mediated bicarbonate reabsorption in the renal proximal tubule, resulting in a decrease of sodium, bicarbonate and water reabsorption. A study in humans concluded that liraglutide, another GLP-1 agonist, decreases the proximal tubular sodium reabsorption, but has no effect on glomerular filtration rate or renal blood flow [3]. Thus, the GLP-1 agonists and especially dulaglutide could probably have a potential interest in disorders of sodium retention. References [1] Crajoinas RO et al. Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1. Am. [3] Skov J et al. Short-term effects of liraglutide on kidney function and vasoac-tive hormones in type 2 diabetes: a randomized clinical trial. Diabetes Obes. Metab. (2016) 18: 581-589. PS1-002 A comparative study of QT prolongation with Serotonin Reuptake Inhibitors (SRIs) A Senard-Ojedo, L Chebane, M Araujo, V Rousseau, F Montastruc, JL Montastruc Laboratoire de Pharmacologie M edicale et Clinique, Centre Midi-Pyr en ees de PharmacoVigilance, de Pharmaco epid emiologie et d'Informations sur le M edicament, Pharmacop^ ole Midi-Pyr en ees, INSERM UMR 1027, CHU et Facult e de M edecine-Toulouse (France) Introduction: QT interval prolongations were described with citalopram or esci-talopram. However, the effects of the other SRIs remai...

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Section: Discussionsupporting

confidence: 58%

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confidence: 99%

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confidence: 99%

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Role of Vasopressin in the Regulation of Renal Sodium Excretion: Interaction with Glucagon‐Like Peptide‐1

Kutina

Golosova

Marina

et al. 2016

J Neuroendocrinology

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“…Therefore, it can be suggested that urine excretion after the maximum WL is equal to the volume of the fl uid that fl ows into the initial part of the distal nephron segment (fl dist ). This approach allows us to perform quantitative analysis of this index for renal function [5]: fl dist =diuresis (Table 1). GLP-1 and exenatide reduce proximal reabsorption due to blockade of the Na + /H + exchanger [7,11].…”

Section: Resultsmentioning

confidence: 99%

Redistribution of Proximal and Distal Reabsorption of Water and Ions in Rat Kidney After Treatment with Glucagon-Like Peptide-1 Mimetic

2015

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Injection of a glucagon-like peptide-1 mimetic accelerated recovery of the initial status of water-salt balance in rats after water or saline load (2.5% NaCl). This effect is mediated by a decrease in proximal fluid reabsorption and change in ion and water transport in the distal part of renal tubules. We developed a new approach to calculation of additional fluid inflow from the proximal tubule to the distal tubule and distal sodium reabsorption under the influence of this mimetic in rats. The expected values corresponded to experimental results, which confirmed our hypothesis on the physiological mechanism for the involvement of the kidneys in the homeostatic effect of glucagon-like peptide-1 under variations in water-salt balance.

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Involvement of Glucagon-Like Peptide-1 in the Regulation of Selective Excretion of Sodium or Chloride Ions by the Kidneys

et al. 2017

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An increase of total glucagon-like peptide-1 (GLP-1) concentration in the plasma in rats was revealed 5 min after oral, but not intraperitoneal administration of NaCl or Trizma HCl solutions. The increase in GLP-1 level was similar to that after oral glucose administration. After intraperitoneal administration of 2.5% NaCl, GLP-1 mimetic exenatide accelerated natriuresis and urinary chloride excretion. Under conditions of normonatriemia and hyperchloremia induced by injection of 6.7% Trizma HCl, exenatide stimulated chloride excretion and reabsorption of sodium ions in the kidneys. These findings suggest that GLP-1 participates in selective regulation of the balance of sodium and chloride ions.

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The role of incretin as an integrator of sodium and water balance regulation

Cited by 7 publications

References 11 publications

Role of Vasopressin in the Regulation of Renal Sodium Excretion: Interaction with Glucagon‐Like Peptide‐1

Role of Vasopressin in the Regulation of Renal Sodium Excretion: Interaction with Glucagon‐Like Peptide‐1

Redistribution of Proximal and Distal Reabsorption of Water and Ions in Rat Kidney After Treatment with Glucagon-Like Peptide-1 Mimetic

Involvement of Glucagon-Like Peptide-1 in the Regulation of Selective Excretion of Sodium or Chloride Ions by the Kidneys

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