The qualitative analysis of farmers’ use of Indigenous knowledge on climate change adaptation across farming systems and agroecological zones of Sierra Leone was conducted using a combination of interpretive phenomenological analysis, Focus Group Discussions, and participant observation, which was analyzed with a qualitative interpretative approach. Farmers respond to climate change through the use of wind and cloud patterns, animal and bird behavior, moon shape, and position of the sun to predict changes in temperature, intensity, drying up of rivers, and frequency of rainfall, as well as the incidence of pests and diseases. Other Indigenous knowledge used by farmers were rotational grazing, migration, crop-livestock integration, and the use of manure for composting with herbal and biological treatment for disease management. The study recommended that in the current context of climate change, the promotion of adaptation strategies should explore the interdependency of different knowledge systems and knowledge hybridity in agriculture.