The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

Abstract

Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck tissues, is characterized by high rates of recurrence and metastasis. Inflammation is important in HNSCC prognosis. Inflammatory cells and their secreted factors contribute to the various stages of HNSCC development through multiple mechanisms. In this review, the mechanisms through which inflammatory factors, signaling pathways, and cells contribute to the initiation and progression of HNSCC have been discussed in detail. Furthermore, the diagnostic and therapeutic potential of targeting inflammation in HNSCC has been discussed to gain new insights into improving patient prognosis.

ECT2 promotes the occurrence and is a prognostic biomarker of head and neck squamous cell carcinoma

“…Inflammation may promote tumor formation and invasion through various pathways. The activity of mononuclear cells may play a significant role in this process 41 . Studies indicate that B cells may participate in immune surveillance by producing antibodies, and B cells could represent a promising new direction for HNSCC therapy, allowing HNSCC patients to benefit from an immunotherapeutic perspective 42 .…”