The role of inflammation in the development of chronic lung disease in neonates

Dooy, Jozef J. De; Mahieu, Ludo; Bever, Hugo P. Van

doi:10.1007/s004310100785

Cited by 93 publications

(53 citation statements)

References 51 publications

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“…It has been proposed that CLD is mediated by higher proinflammatory cytokines (IL-6, TNF-␣, and IL-8) in conjunction with a lower anti-inflammatory (IL-10) cytokine arising from proinflammatory response (7,8,19,20). It remains unclear which cytokine is actually involved in the development of CLD.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Augmented IL-8 Production to Premature Chronic Lung Disease: Implication of Posttranscriptional Regulation

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Correlation of Augmented IL-8 Production to Premature Chronic Lung Disease: Implication of Posttranscriptional Regulation

et al. 2005

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“…However, recent research has focused on the roles of perinatal infection and the inflammatory response as critical factors influencing chronic lung injury (7,16). Particular attention has been paid to the role of Ureaplasma species, fastidious bacteria found in the lower genital tracts of 40 to 80% of asymptomatic women (4).…”

mentioning

confidence: 99%

Characterization of Ureaplasmas Isolated from Preterm Infants with and without Bronchopulmonary Dysplasia

Katz¹,

Patel²,

Duffy³

et al. 2005

J Clin Microbiol

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A PCR assay was used to analyze endotracheal aspirates from preterm infants for Ureaplasma parvum versus U. urealyticum. U. parvum was detected more often than U. urealyticum. There was no significant difference or trend in the prevalence of either species between infants with or without bronchopulmonary dysplasia when isolated alone.The major factor leading to high morbidity and mortality of preterm infants is pulmonary immaturity. This manifests as respiratory distress in the early neonatal period and can develop into bronchopulmonary dysplasia (BPD), currently defined as a supplemental oxygen requirement at 36 weeks postmenstrual age, with characteristic radiographic findings (2). A recent survey reported that the incidence of BPD ranged from 67% among infants with birth weights of 500 to 750 g to Ͻ1% in infants weighing 1,250 to 2,500 g (2).Development of BPD is multifactorial and is related to pulmonary immaturity, oxidant injury due to high levels of inspired oxygen, and volutrauma associated with mechanical ventilation. However, recent research has focused on the roles of perinatal infection and the inflammatory response as critical factors influencing chronic lung injury (7, 16). Particular attention has been paid to the role of Ureaplasma species, fastidious bacteria found in the lower genital tracts of 40 to 80% of asymptomatic women (4). Rates of vertical transmission range from 18 to 88%, varying inversely with gestational age (6,8,12,24,25). Ureaplasma spp. are the most common microorganisms isolated from inflamed placentas and the lower respiratory tracts of neonates and are proven causes of neonatal pneumonia (4). Since initial reports associating ureaplasmal colonization and development of BPD were published in 1988 (5, 23, 26), more than 30 studies have been conducted. Most, but not all, have supported this association, despite major changes in the pulmonary management of very-low-birth-weight infants, such as exogenous surfactant, antenatal corticosteroid administration, and high frequency ventilation.

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“…Therefore, the lung contributes to the circulation of cells and inflammatory mediators through the whole body. 1,14,15,20,21 Healing There are two outcomes for the inflammatory process: repair of pulmonary structures with restoration of normal lung function, or fibrosis, causing impairment of respiratory function. The outcome to be achieved depends on several factors, such as nutritional status, inflammatory mediators, genetic factors, among others, as previously described.…”

Section: Factors Associated With Lung Injurymentioning

confidence: 99%

Displasia broncopulmonar

Monte¹,

Filho²,

Miyoshi³

et al. 2005

J. Pediatr. (Rio J.)

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Objective: To present a wide-ranging review of the literature on bronchopulmonary dysplasia, covering new definitions, pathophysiology, prevention, treatment, prognosis and progression. Sources of data:The most relevant articles published on the subject since it was first described in 1967 were selected from MEDLINE search results. Summary of the findings:Bronchopulmonary dysplasia is considered one of the primary causes of chronic lung disease among infants. It is associated with frequent and prolonged hospital admissions, in particular for pulmonary diseases, with high rates of mortality and alterations to neuropsychomotor development and pondero-statural growth. Pathogenesis is complex, being primarily influenced by prematurity, infection, supplementary oxygen and mechanical ventilation. Prevention involves appropriate prenatal care, the prevention of premature delivery, prenatal corticosteroids, surfactant replacement therapy and protective ventilatory strategies. Treatment of bronchopulmonary dysplasia patients demands a multidisciplinary team. When indicated, oxygen supplementation is extremely important. Despite increased risk of morbidity and mortality during the first years of life, long term progress is favorable in the majority of cases.Conclusions: Bronchopulmonary dysplasia has been and continues to be studied in great depth with the objective of identifying its causes and possible prevention and treatment strategies. Controversies remain with respect of these issues and also about the prognosis of these patients, in particular when the subject is long-term progress of new bronchopulmonary dysplasia patients.J Pediatr (Rio J). 2005;81(2):99-110: Bronchopulmonary dysplasia, oxygen therapy, mechanical ventilation, corticosteroid, prevention, treatment, progression.

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The role of inflammation in the development of chronic lung disease in neonates

Abstract: Many aspects of the pathogenesis of the inflammatory response in the development of chronic lung disease remain to be elucidated. Further research to identify preterm infants at highest risk for the development of this multifactorial and complex disease is needed.

Cited by 93 publications

References 51 publications

Correlation of Augmented IL-8 Production to Premature Chronic Lung Disease: Implication of Posttranscriptional Regulation

Correlation of Augmented IL-8 Production to Premature Chronic Lung Disease: Implication of Posttranscriptional Regulation

Characterization of Ureaplasmas Isolated from Preterm Infants with and without Bronchopulmonary Dysplasia

Displasia broncopulmonar

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