The role of insufficient copper in lipid synthesis and fatty‐liver disease

Morrell, Austin; Tallino, Savannah; Lei, Yu; Burkhead, Jason L.

doi:10.1002/iub.1613

Cited by 99 publications

(67 citation statements)

References 83 publications

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“…Dysregulation of lipid metabolism is a symptom of dietary copper deficiency or overload (83)(84)(85). Moreover, during the progression of diet-induced non-alcoholic fatty liver disease, liver copper levels decrease and the expression of copper homeostasis proteins is altered (86,87).…”

Section: Copper Regulation Of Fat Metabolismmentioning

confidence: 99%

Copper signaling in the brain and beyond

Ackerman

Chang

2018

Journal of Biological Chemistry

151

124

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Transition metals have been recognized and studied primarily in the context of their essential roles as structural and metabolic cofactors for biomolecules that compose living systems. More recently, an emerging paradigm of transition metal signaling, where dynamic changes in transition metal pools can modulate protein function, cell fate, and organism health and disease, has broadened our view of the potential contributions of these essential nutrients in biology. Using copper as a canonical example of transition metal signaling, we highlight key experiments where direct measurement and/or visualization of dynamic copper pools, in combination with biochemical, physiological, and behavioral studies, have deciphered sources, targets, and physiological effects of copper signals.

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Section: Copper Regulation Of Fat Metabolismmentioning

confidence: 99%

Copper signaling in the brain and beyond

Ackerman

Chang

2018

Journal of Biological Chemistry

151

124

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“…The significance of maintaining the homeostasis of essential microelements cannot be overrated, considering the participation of iron and copper in the development of diseases of this organ [15,16], the role of manganese superoxide dismutase in liver tumour suppression [17], or the protective effect of zinc in the case of hepatoxicity of lithium [12]. Additionally, the necessity of maintaining the proper liver functions must be highlighted, considering that lithium therapy in psychiatric subjects is usually used for some years [4].…”

Section: Discussionmentioning

confidence: 99%

Homeostasis of chosen microelements in liver of rats receiving lithium and/or selenium orally

Kiełczykowska¹,

Kopciał²,

Marzec³

et al. 2017

J Pre Clin Clin Res.

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Introduction and objective. Lithium and selenium have been the subjects of extensive research for many years. Concern about the physiological action of these elements results from the application of lithium in medicine, as well as the beneficial influence of selenium supplementation in different pathological states. However, little data are available concerning their effect on the homeostasis of essential microelements in organs. Therefore, the aim of the current study was to evaluate the influence of lithium and/or selenium administration on homeostasis of iron, zinc, copper and manganese in the liver of rats. Materials and method. The experiment was carried on 24 male Wistar rats (4 groups of 6 animals) subjected to the treatment with: group I (control) -saline; group II -lithium carbonate at a dose of 2.7 mg Li/kg b.w.; group III -sodium selenite at a dose of 0.5 mg Se/kg b.w.; group IV -both lithium carbonate and sodium selenite at the doses mentioned above. Administration was performed for 6 weeks, once a day by stomach tube, in the form of water solutions. Results. The tissue content of zinc, iron and manganese showed no statistical differences among the studied groups. Zn was slightly decreased in group III vs. control and group II. Fe was insignificantly enhanced in groups II and IV vs. control. Mn in group IV was slightly increased vs. groups II and III. Cu in group III was significantly decreased vs. group IV and slightly depleted vs. groups I and II. Conclusion. With the exception of Cu in the Se-treated group, lithium and/or selenium did not affect the studied microelements' liver homeostasis in a significant way. These results may contribute to the knowledge of essential microelements homeostasis in human organisms undergoing lithium therapy, and/or selenium supplementation.

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“…Copper is an essential cofactor of numerous critical enzymes in metabolism (Table ). It is involved in fat metabolism, in particular of lipoproteins: Marginal copper deficiency has been reported as a potential etiologic factor in diseases characterized by disrupted fat metabolism such as nonalcoholic fatty liver disease . The oxidation of low‐density lipoproteins (LDLs) is thought to play a significant role in atherosclerosis: Low copper status is associated with reduced activity of superoxide dismutase (SOD), which favors LDL oxidations.…”

Section: Copper Metabolismmentioning

confidence: 99%

Copper Deficiency: Causes, Manifestations, and Treatment

et al. 2019

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Background: The metabolism of the essential trace element copper remains incompletely understood and, until recently, nearly ignored in acute medicine. Menkes disease was for long the only known copper deficiency condition, but several case reports and investigations conducted over the last 2 decades have shown that deficiency is more frequent than previously suspected, with devastating individual consequences and potential public health consequences. The copper needs in healthy individuals are 0.9 mg/d, which translates to 0.3 mg/d intravenously in parenteral nutrition; the present review aims at gathering actual knowledge. Method and results: A review of literature was conducted in PubMed and Cochrane systematic reviews to identify the most recent information about copper deficiency and generate a narrative review. Copper deficiency has hereditary and acquired origins, the latter being the most frequent. Clinical manifestations are nonspecific but affect all organs and systems, particularly the hematologic (anemia) and the neurologic (myeloneuropathy) systems. Deficiency also affects the cardiovascular, cutaneous, and immune systems. Severe copper deficiency due to reduced absorption after bariatric bypass surgery has become frequent. Conclusion: Deficiency is more frequent than previously recognized, probably because of changing nutrition patterns but also because of some treatments that have become very common such as bypass bariatric surgery and, in acute medicine, prolonged continuous renal replacement therapy. The patients may present with severe hematologic and neurologic complications that go untreated because copper deficiency was not considered in the differential diagnosis: These complications often need active intravenous repletion with doses 4-8 times the usual nutrition recommendations. (Nutr Clin Pract. 2019;34:504-513)

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The role of insufficient copper in lipid synthesis and fatty‐liver disease

Cited by 99 publications

References 83 publications

Copper signaling in the brain and beyond

Copper signaling in the brain and beyond

Homeostasis of chosen microelements in liver of rats receiving lithium and/or selenium orally

Copper Deficiency: Causes, Manifestations, and Treatment

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