The role of interactions between the cholinergic system and other neuromodulatory systems in learing and memory

Decker, Michael; McGaugh, James L.

doi:10.1002/syn.890070209

Cited by 502 publications

(187 citation statements)

References 205 publications

(160 reference statements)

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“…This apparent dissociation between neurochemistry and behavior suggests that the effects of HC-3 are probably not directly exerted on memory retrieval, and indicates that HACU inhibition took place at early stages of memory consolidation (10). These results agree with experimental and clinical evidence suggesting that brain Ach plays an essential role in mnemonic phenomena (27,28).…”

Section: Pharmacological Manipulation Of Memory Consolidation and Recsupporting

confidence: 78%

Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation

Baratti

Boccia

Blake

2009

Braz J Med Biol Res

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In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis".

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Section: Pharmacological Manipulation Of Memory Consolidation and Recsupporting

confidence: 78%

Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation

Baratti

Boccia

Blake

2009

Braz J Med Biol Res

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“…Hemicholinium (HC-3) is a specific inhibitor of the high-affinity choline uptake in brain cholinergic neurons. Accordingly, the pharmacological inhibition, at first, could only be attributed to the cholinergic synapse depressed function, although this dysfunction could modify additional neuronal systems (Decker and McGaugh 1991).…”

Section: Discussionmentioning

confidence: 99%

Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory

Boccia¹,

Blake²,

Acosta³

et al. 2006

Learn. Mem.

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CF-1 male mice were trained in an inhibitory avoidance task using a high footshock (1,2 mA, 50 Hz, 1 sec) in order to reduce the influence of extinction on retention performance. At 2, 7, 14, or 30 d after training, the first retention test was performed and hemicholinium (HC-3, 1.0 µg/mice), a specific inhibitor of high-affinity choline uptake in brain cholinergic neurons, was given intracerebroventricularly immediately after. Twenty four hours after treatment, mice were tested in an inhibitory avoidance task during five consecutive days, each 24 h apart. Retention performance was impaired by HC-3 when the first re-exposure took place at 2, 7, or 14 d, but the effect was no longer seen when re-exposure occurred 30 d after training. We did not find spontaneous recovery 21 d after training, when memory was retrieved 2 d after training and HC-3 was given immediately after. Although we cannot definitively discard a retrieval deficit, this lack of spontaneous recovery is in accordance with the storage-deficit interpretation. These results confirm and extend previous ones, suggesting that central cholinergic mechanisms are involved in the hypothetical reconsolidation memory processes of an inhibitory avoidance task in mice and also suggest that this participation depends on the "age" of the original memory trace. This implies that the vulnerability of a reactivated memory to a specific treatment, as the one used in this study, inversely correlates with the age of the original memory, and it is likely to determine memory reconsolidation processes.

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“…Different pathological manifestations of AD, such as b-amyloidosis, presence of tangles and dystrophic neurites, synapse loss and various neurotransmitters deficits render unlikely that cholinergic dysfunction could account for all cognitive and non-cognitive symptoms. Furthermore, several neurotransmitters, including dopamine, GABA, noradrenaline, serotonin and histamine, are clearly implicated in cognitive processes and interact with the cholinergic system [33,99]. Since abnormalities of these neurotransmitter systems have been identified in Alzheimer's disease and aging [1,57], these alterations might well interact with those of ACh to cause additive or even synergistic effects on cognition.…”

Section: Introductionmentioning

confidence: 99%

Interactions between histaminergic and cholinergic systems in learning and memory

Bacciottini

Passani

Mannaioni

et al. 2001

Behavioural Brain Research

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The aim of this review is to survey biochemical, electrophysiological and behavioral evidence of the interactions between the cholinergic and histaminergic systems and evaluate their possible involvement in cognitive processes. The cholinergic system has long been implicated in cognition, and there is a plethora of data showing that cholinergic deficits parallel cognitive impairments in animal models and those accompanying neurodegenerative diseases or normal aging in humans. Several other neurotransmitters, though, are clearly implicated in cognitive processes and interact with the cholinergic system. The neuromodulatory effect that histamine exerts on acetylcholine release is complex and multifarious. There is clear evidence indicating that histamine controls the release of central acetylcholine (ACh) locally in the cortex and amygdala, and activating cholinergic neurones in the nucleus basalis magnocellularis (NBM) and the medial septal area-diagonal band that project to the cortex and to the hippocampus, respectively. Extensive experimental evidence supports the involvement of histamine in learning and memory and the procognitive effects of H 3 receptor antagonists. However, any attempt to strictly correlate cholinergic/histaminergic interactions with behavioral outcomes without taking into account the contribution of other neurotransmitter systems is illegitimate. Our understanding of the role of histamine in learning and memory is still at its dawn, but progresses are being made to the point of suggesting potential treatment strategies that may produce beneficial effects on neurodegenerative disorders associated with impaired cholinergic function.

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The role of interactions between the cholinergic system and other neuromodulatory systems in learing and memory

Cited by 502 publications

References 205 publications

Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation

Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation

Post-retrieval effects of icv infusions of hemicholinium in mice are dependent on the age of the original memory

Interactions between histaminergic and cholinergic systems in learning and memory

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