The role of interferon-gamma on immune and allergic responses

Abstract

Allergic diseases have been closely related to Th2 immune responses, which are characterized by high levels of interleukin (IL)

Effect of medical castration on CD4+CD25+T cells, CD8+T cell IFN-γ expression, and NK cells: a physiological role for testosterone and/or its metabolites

“…IFN-␥ is a major inflammatory cytokine functioning in host defense against viral infections and tumor development (36,43). Hence, our observations of impaired activation of CD8 ϩ T cells of castrated men suggests a possible mechanism by which T and/or its metabolites impact adaptive immunity.…”

Long Exposure to CdS-Dextrin Nanoparticles Induces an Immunomodulatory and Anti-Inflammatory Effect in Rats

“…Th1 cytokines are related to cellular response and activate cytolytic lymphocytes and macrophages. In contrast, Th2 cytokines are related to humoral response and inhibit the activation of macrophages; they also promote the development of allergies and autoimmune diseases [36]. We know that, during an inflammatory process, either Th1 or Th2 lymphocytes can oscillate toward a middle pathway in order to attain balance.…”

Safety Evaluation of Hypoallergenic Wheat Flour by Using a DNA Microarray

“…The results do not necessarily mean that the product of these genes would directly affect the immunoresponse; other genes downstream of the IFN-signal may play more important roles. The status of IFN-signaling, including the phosphorylation of STAT1, 20) being actually up-regulated by HWF feeding needs to be addressed. Also important are an analysis of the Th1/ Th2 balance and identification of the molecules that directly modulate IgE production in this situation.…”