The Role of Interferon in Persistent Infection with Foot-and-Mouth Disease Virus

Philipson, Lennart; Dinter, Z.

doi:10.1099/00221287-32-2-277

Cited by 15 publications

(4 citation statements)

References 14 publications

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“…Several persistent infections of tissue cultures are thought to be caused by the interferon system, although only a few definitive studies have been reported. Interferon has been detected at very early and at advanced stages of persistent infection of mouse L cells with Newcastle disease virus (122)(123)(124), human amnion and KB cells with poliovirus (125), calf kidney cells with the WS strain of influenza virus and with foot-and-mouth disease virus (126,127), KB cells with parainfluenza type 3 virus (128), mouse embryo cells with vaccinia virus (50), human amnion and mouse L cells with tick-borne encephalitis virus (53,129), mouse 23 P cells with polyoma virus and with herpes simplex virus (90), and monkey cells with rubella virus (130). Similar results have been observed during the early period of infection of mice with lactic dehydrogenase virus (32).…”

Section: Infectionsmentioning

confidence: 99%

The Defensive Role of the Interferon System

Baron

1970

The Journal of General Physiology

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The evidence relating the interferon system to the infectious process has been examined. The available evidence supports the view that the interferon system is an important component of the body's nonimmune defenses, which are probably the major causes of recovery from already established virus infections of body tissues. The interferon system can also serve to limit virus spread through the bloodstream. Factors which may influence the interferon system and thereby influence virus infection have been considered. Finally, evidence is presented which indicates that the interferon system is one of the determinants of virulence of certain viruses and is one of the determinants of some persistent virus infections.The discovery of interferons by Isaacs and Lindenmann (1) led, within a short time, to major revisions in concepts of cellular immunity and recovery of multicellular organisms from infection. The significance of the antiviral effect of the interferon system extends to virus infections of the acute, chronic, and oncogenic varieties. More recent evidence suggests that the interferon system may play a role during infection by Chlamydia and certain protozoal parasites. This section will consider the implications of the interferon system as a host defense during infection. Several reviews contain related information (2-9). A more detailed consideration of the various host defenses during viral infection will be published (10). COMPONENTS OF THE INTERFERON SYSTEMThe term "interferon system" is used because this anti-infectious mechanism is now thought to be divisible into several components. For the present purposes we will refer to interferon as a protein(s) which is produced or released by cells following viral infection and certain other stimuli. Available evidence suggests that interferon is not itself directly antiviral, but rather, it reacts with cells to induce the formation of a new intracellular substance which mediates the antiviral activity. This antiviral component of the interferon system may be a polypeptide or a protein.

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Section: Infectionsmentioning

confidence: 99%

The Defensive Role of the Interferon System

Baron

1970

The Journal of General Physiology

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“…P~IILIPSO~ and DINTEI~ (14) reported the presence of detectable interferon 4 days after establishment of FMDV persistent calf kidney cell cultures, but the interferon titers were too low to be detected after 10 days. The failure to detect interferon may be due to several possibilities: 1) the interferon Present might be bound intracellularly as suggested by HENLE et al (9) for myxoviruses or 2) the test system for interferon may not be sensitive enough to detect minute amounts of interferon.…”

Section: Discussionmentioning

confidence: 95%

Foot-and-mouth disease virus carrier state in cells cultured from tissues of convalescent cattle

Mohanty

Cottral

1971

Archiv f Virusforschung

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SummaryCultures were made from mucosal tissues of the pharynx, esophagus, rumen and tongue of cattle convalescent (7 days) from foot-and-mouth disease (FMD) infection. The persistence of FMD virus in the cell cultures was demonstrated by fluorescent antibody technique and by subcultures in primary swine kidney cells using cytopathic effect and plaque assay techniques.Virus persisted in the cell cultures and was found in the supernatant fluids, in washed and lysed cells, and in cells by fluorescent antibody reaction of the various samples for the number of weeks indicated, respectively: tongue --3, 3, 5; rumen --5, 5, 7; pharynx --25, 25, 24; and esophagus --25, 16 (intermittently), 24. Interferon was not detected in the supernatant fluids of any of the cultures.The virus-laden cultures did not show gross signs of infection, whereas mucosal cultures from similar areas of normal cattle were destroyed in about 28 hours after inoculation with stock virus. Both the infected cultures and noninfected normal cultures deteriorated after 25 to 26 weeks.The can-ier virus isolated at 22 weeks from the esophageal and pharyngeal cultures showed decreased pathogenicity to different primary and cell line kidney cultures and to mice, as compared to the parent virus. The carrier viral isolates were infective for cattle. However, esophageal-pharyngeal (EP) fluids from steers inoculated with the carrier virus isolated from the esophageal culture at 22 weeks contained more virus at 7 and 24 days than the EP fluids from a steer inoculated with the carrier virus isolated from the pharyngeal cell cultures.

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“…The initiation of persistence of FMD virus has been correlated with the production of interferon in cells [45], possibly due to an alteration of the cells. This observation is supported by recent experimental evidence that the FMD virus persistently infected cell phenotype is altered significantly from the parental strain [46].…”

Section: Viral Mechanismsmentioning

confidence: 99%

A review of the possible mechanisms for the persistence of foot-and-mouth disease virus

Woodbury¹

1995

Epidemiol. Infect.

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Foot-and-mouth disease (FMD) was the first animal disease to be attributed to a virus, and the second virus to be discovered [1]. It is a positive-sense, singlestranded RNA picornavirus and the sole member of the genus Aphthovirus. Each infectious virus particle contains a single strand of RNA approximately 8-5 kb long. This is translated into a single polypeptide which is then cleaved into the structural and non-structural virus proteins.

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The Role of Interferon in Persistent Infection with Foot-and-Mouth Disease Virus

Cited by 15 publications

References 14 publications

The Defensive Role of the Interferon System

The Defensive Role of the Interferon System

Foot-and-mouth disease virus carrier state in cells cultured from tissues of convalescent cattle

A review of the possible mechanisms for the persistence of foot-and-mouth disease virus

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