2023
DOI: 10.3390/jpm13121675
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The Role of Interleukins in HBV Infection: A Narrative Review

Konstantinos Dimitriadis,
Stamatia Katelani,
Maria Pappa
et al.

Abstract: Hepatitis B virus (HBV) infection is a worldwide medical issue with significant morbidity and mortality, as it is the main cause of chronic liver disease and hepatocellular carcinoma (HCC). Both innate and adaptive immune responses play a key role in HBV replication and suppression. Recently, the pathophysiological function of interleukins (IL) in the natural course of HBV has gained much attention as a result of the broad use of anti-interleukin agents for a variety of autoimmune diseases and the accompanying… Show more

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Cited by 6 publications
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“…HBV primarily replicates in hepatocytes and can persist for a long time despite constantly improving treatment options. The interplay of innate and adaptive immune responses plays a key role in the defense against HBV and is decisive for the course of the infection [3,4]. Viral infection usually leads to a rapid immune response of the innate immune system in order to prevent the persistence of the virus and to stimulate further antiviral mechanisms [5,6].…”
Section: Introductionmentioning
confidence: 99%
“…HBV primarily replicates in hepatocytes and can persist for a long time despite constantly improving treatment options. The interplay of innate and adaptive immune responses plays a key role in the defense against HBV and is decisive for the course of the infection [3,4]. Viral infection usually leads to a rapid immune response of the innate immune system in order to prevent the persistence of the virus and to stimulate further antiviral mechanisms [5,6].…”
Section: Introductionmentioning
confidence: 99%