The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy

Dong, Fangyuan; Su, Jindi; Chen, Lu; Zhang, Shaochong

doi:10.3389/fmed.2021.802626

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Therefore, we believe the middle retinoschisis indicates potent traction on the retina. Some studies showed that inner retinoschisis was associated with the disease progression [ 18 , 38 , 39 ]. The relationship between the number of retinoschisis layers and the advanced stage indirectly supported the opinion.…”

Section: Discussionmentioning

confidence: 99%

Multimodal Analysis on Clinical Characteristics of the Advanced Stage in Myopic Traction Maculopathy

et al. 2023

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Introduction Here we investigate the clinical features of foveal detachment (FD), full-thickness macular hole (MH), and macular hole retinal detachment (MHRD) in myopic traction maculopathy (MTM). Methods In the retrospective observational case series, 314 eyes of 198 patients with myopic retinoschisis in Beijing Tongren Hospital were enrolled. We recorded gender, age, and axial length and evaluated fundus characteristics using optical coherence tomography. Epiretinal membranes (ERMs), vitreoretinal traction, and paravascular abnormalities (PVAs) were used to describe the vitreoretinal interface condition. Different retinoschisis layers (inner, middle, and outer retinoschisis) and the location with a range of outer retinoschisis were evaluated to reveal the retinal condition. Five patterns of the scleral shape: dome-shaped, sloped toward the optic nerve, symmetrical or asymmetrical around the fovea, and irregular were assessed to show retina-sclera condition. We regarded the FD, full-thickness MH, and MHRD as the advanced stage in MTM. Multivariate logistic regression assessed significant factors for the advanced stage with odds ratios (OR) and 95% confidence intervals (CI). Results There were 76 eyes with FD, 6 eyes with full-thickness MH, and 7 eyes with MHRD. The mean age was 52.9 ± 12.3 years. On univariate analysis, the eyes with the advanced stage were older and had higher rates of ERMs, PVAs, middle retinoschisis, outer retinoschisis, and irregular sclera shape. The number of retinoschisis layers and the grade of outer retinoschisis were higher in eyes with the advanced stage. After multivariate logistic regression, ERMs (OR 1.983; 95% CI 1.093–3.595; P = 0.024), middle retinoschisis (OR 2.967; 95% CI 1.630–5.401; P < 0.001), and higher grades of outer retinoschisis (OR 2.227; 95% CI 1.711–2.898; P < 0.001) remained associated with the advanced stage. Conclusion ERMs, middle retinoschisis, and more extensive outer retinoschisis were significant characteristics of the advanced stage in MTM.

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Section: Discussionmentioning

confidence: 99%

Multimodal Analysis on Clinical Characteristics of the Advanced Stage in Myopic Traction Maculopathy

et al. 2023

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Biomarkers: Promising Tools Towards the Diagnosis, Prognosis, and Treatment of Myopia

Ruamviboonsuk,

Lanca,

Grzybowski

2024

JCM

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The prevalence of myopia, especially high myopia, continues to increase in several parts of the world. Thus, the use of biomarkers for early myopia detection would be highly valuable for clinical practice aiding in the prevention and myopia control management. The identification of biomarkers that can predict the risk of myopia development, severity of myopia, and treatment response are of paramount significance. In this review, we present the current state of research on biomarkers and myopia, highlighting the challenges and opportunities in biomarkers research for myopia. Although myopia biomarkers may have a role as early indicators of myopia or treatment response, the adoption of biomarkers into myopia clinical practice may only be done when tests have high accuracy, are easily measurable, minimally invasive, and acceptable to parents, children, and eye care professionals. Large consortia studies are necessary to validate biomarkers and translate evidence into clinical practice.

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The Role of Internal Limiting Membrane as a Biomarker in the Evolution of Myopic Traction Maculopathy

Cited by 2 publications

References 18 publications

Multimodal Analysis on Clinical Characteristics of the Advanced Stage in Myopic Traction Maculopathy

Multimodal Analysis on Clinical Characteristics of the Advanced Stage in Myopic Traction Maculopathy

Biomarkers: Promising Tools Towards the Diagnosis, Prognosis, and Treatment of Myopia

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