The Role of Intestinal Barrier Function in Early Life in the Development of Colitis

Anderson, Rachel C.; Dalziel, Julie E.; Gopal, Pramod K.; Bassett, Shalome A.; Ellis, Anthony; Roy, Nicole C.

doi:10.5772/25753

Cited by 42 publications

(53 citation statements)

References 142 publications

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“…80 Furthermore, epithelium cell tight-junctions and gut microbial flora of neonates are not yet fully developed and therefore would not be as effective in preventing invasion of pathogens such as C. sakazakii from entering the blood stream. 81 Taken together with high levels of LPS found in PIF, and the contamination of PIF with C. sakazakii, this could provide an underlying mechanism for the observed tenfold higher incidence rate of NEC observed in infants fed with PIF compared to breast fed infants. 82 Outer membrane protein A (OmpA) of C. sakazakii has been shown to be necessary for invasion of Caco-2 and INT407 cells, [83][84][85] since the invasiveness of a DompA mutant decreased by 80% in Caco-2 and 87% in INT407 cells.…”

Section: Crossing the Gut Barrier-invasionmentioning

confidence: 98%

Cronobacter sakazakii: stress survival and virulence potential in an opportunistic foodborne pathogen

et al. 2014

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Section: Crossing the Gut Barrier-invasionmentioning

confidence: 98%

Cronobacter sakazakii: stress survival and virulence potential in an opportunistic foodborne pathogen

et al. 2014

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“…Besides CYP3A activity in the gut wall and liver, important factors that may affect the absorption and metabolism of drugs in the gut wall are among others the intestinal surface area and the permeability of the endothelium. 14 Preterm infants have a smaller surface area and are known to have an underdeveloped intestinal barrier, 15 resulting in a higher intestinal permeability in neonates with gestational ages of <34 weeks. 16 To describe and predict pharmacokinetic (PK) profiles and drug exposure in patients, different types of models have been used based on availability of data and their purpose.…”

Section: Study Highlightsmentioning

confidence: 99%

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

Brussee

Krekels

et al. 2018

CPT Pharmacom & Syst Pharma

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To predict first‐pass and systemic cytochrome P450 (CYP) 3A‐mediated metabolism of midazolam in preterm neonates, a physiological population pharmacokinetic model was developed describing intestinal and hepatic midazolam clearance in preterm infants. On the basis of midazolam and 1‐OH‐midazolam concentrations from 37 preterm neonates (gestational age 26–34 weeks) receiving midazolam orally and/or via a 30‐minute intravenous infusion, intrinsic clearance in the gut wall and liver were found to be very low, with lower values in the gut wall (0.0196 and 6.7 L/h, respectively). This results in a highly variable and high total oral bioavailability of 92.1% (range, 67–95%) in preterm neonates, whereas this is around 30% in adults. This approach in which intestinal and hepatic clearance were separately estimated shows that the high bioavailability in preterm neonates is explained by, likely age‐related, low CYP3A activity in the liver and even lower CYP3A activity in the gut wall.

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“…Infant will take at least one year for his gastrointestinal tract to significantly develop and mature [10]. Due to this, World Health Organization [1] recommended mothers to exclusively breastfeed their infants for at least six months.…”

Section: Recommendation Of Breastfeedingmentioning

confidence: 99%

The association of maternal diet and polyamines in human milk: a study among malay ethnic mothers in kuantan, malaysia

kamaruzzaman¹,

Ghani²,

Ibrahim³

et al. 2018

IJET

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Human milk contains a lot of nutrient and it offers advantages to infant age less than six months. Polyamines in milk accelerate the infants' gut maturation and protect babies from the harsh environment. Maternal diet is a factor which can affect the polyamines variability in milk. To date, no research on local diet and the composition of human milk has been investigated. This study aimed to identify an association between Malaysian maternal diet and composition of polyamines in human milk. Seventy nursing mothers were recruited in Pahang and each mother recorded their 24-hours food consumption within a week. Maternal diets were recorded in Nutritionist Prosoftware and the macronutrients were calculated. Milk samples were collected from each mother after24 h of food diary. Polyamines in milk were extracted using 0.4 M Perchloric acid, dansylated and quantified using HPLC. The mean age of the respondent was 30.13 years [SD= 3.145

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The Role of Intestinal Barrier Function in Early Life in the Development of Colitis

Cited by 42 publications

References 142 publications

Cronobacter sakazakii: stress survival and virulence potential in an opportunistic foodborne pathogen

Cronobacter sakazakii: stress survival and virulence potential in an opportunistic foodborne pathogen

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

The association of maternal diet and polyamines in human milk: a study among malay ethnic mothers in kuantan, malaysia

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