The Role of Intestinal Dysbiosis in the Pathogenesis of Autism: Minireview

Grossi, E; Terruzzi, V

doi:10.19070/2329-9967-140007

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Recently, an increasing amount of studies have been focusing on how the interactions between microbiota and CNS might play a role in the pathophysiology of neuropsychiatric disorders, mostly MDs, OCD, neurodevelopmental disorders (especially ASDs) and neurodegenerative diseases. Therefore, the therapeutic potential of microbiota-targeted treatments was proposed to the extent that some authors proposed to call them "psychobiotics" [43,[81][82][83][84][85][86][87][88].…”

Section: Microbiota and Psychiatric Disordersmentioning

confidence: 99%

The Microbiota/Microbiome and the Gut–Brain Axis: How Much Do They Matter in Psychiatry?

Marazziti

Palermo

Parra

et al. 2021

Life

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The functioning of the central nervous system (CNS) is the result of the constant integration of bidirectional messages between the brain and peripheral organs, together with their connections with the environment. Despite the anatomical separation, gut microbiota, i.e., the microorganisms colonising the gastrointestinal tract, is highly related to the CNS through the so-called “gut–brain axis”. The aim of this paper was to review and comment on the current literature on the role of the intestinal microbiota and the gut–brain axis in some common neuropsychiatric conditions. The recent literature indicates that the gut microbiota may affect brain functions through endocrine and metabolic pathways, antibody production and the enteric network while supporting its possible role in the onset and maintenance of several neuropsychiatric disorders, neurodevelopment and neurodegenerative disorders. Alterations in the gut microbiota composition were observed in mood disorders and autism spectrum disorders and, apparently to a lesser extent, even in obsessive-compulsive disorder (OCD) and related conditions, as well as in schizophrenia. Therefore, gut microbiota might represent an interesting field of research for a better understanding of the pathophysiology of common neuropsychiatric disorders and possibly as a target for the development of innovative treatments that some authors have already labelled “psychobiotics”.

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Section: Microbiota and Psychiatric Disordersmentioning

confidence: 99%

The Microbiota/Microbiome and the Gut–Brain Axis: How Much Do They Matter in Psychiatry?

Marazziti

Palermo

Parra

et al. 2021

Life

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“…However, new anatomical sites for the microbiota including the placenta have been discovered, changing the interpretation of how the fetus becomes colonized. Antibiotic therapy during the perinatal period and poor quality or quantity of breast feeding also contribute to the intestinal dysbiosis observed in patients with necrotizing enterocolitis, inflammatory bowel disease, autism, obesity and colon cancer [7,8,9,10,11,12,13]. All of these observations taken together with the completion of the human microbiome project have elevated the interest in this field of medicine to an even higher level [14].…”

mentioning

confidence: 99%

The Microbiota and Transgenomic Networks: Potential Implications for Maternal-Fetal Medicine

Santolaya-Forgas

Townsend²,

Santolaya³

et al. 2015

Fetal Diagn Ther

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The maternal microbiota has long been considered a potential cause for adverse perinatal outcomes. Gene expression regulators in prokaryotic and eukaryotic cells are influenced by changes in their microenvironments. We propose the novel idea that during in utero development, an adaptive and dynamic gene-regulatory cross talk might exist between the host genome and the maternal microbiota. Understanding these cross talks could increase the appreciation for the discovery of new diagnostics and therapeutics in maternal-fetal medicine.

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The Role of Intestinal Dysbiosis in the Pathogenesis of Autism: Minireview

Cited by 2 publications

References 20 publications

The Microbiota/Microbiome and the Gut–Brain Axis: How Much Do They Matter in Psychiatry?

The Microbiota/Microbiome and the Gut–Brain Axis: How Much Do They Matter in Psychiatry?

The Microbiota and Transgenomic Networks: Potential Implications for Maternal-Fetal Medicine

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