The Role of Intralipid Emulsion in the Rat Model of Digoxin Intoxication

Turan, Cansu; Öztürk, Tuba Cimilli; Akoğlu, Ebru Ünal; Ak, Rohat; Aygün, Kemal; Şahiner, Ali; Sümer, Engin; Somay, Adnan; Onur, Özge

doi:10.1007/s12012-018-9444-4

Cited by 10 publications

(3 citation statements)

References 28 publications

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“…Besides, we observed toxic effects of ILE on the kidney cells in the 2 nd group which we had administered only ILE. Even if the underlying mechanism is not fully understood studies showing that ILE itself is renal toxic, our findings are also consistent with the literature (31,32). Some experimental studies also showed that pioglitazone also has toxic effects on heart tissue.…”

Section: Discussionsupporting

confidence: 92%

Histopathological Changes with Acute Pioglitazone Intoxication and the Effects of Intralipid Emulsion Treatment in Rats

Taşçı,

Ak,

Taşçı

et al. 2024

Preprint

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Introduction: The primary aim of this study is to investigate the histopathologic effects of acute pioglitazone intoxication and the effects of intralipid emulsion treatment in reversing these possible unwanted effects in a rat model. Methods: For the study, 32 Spraque-Dawley rats weighing between 250-300 g were randomly divided into 4 groups. The first group was the control group and 12.4 ml/kg normal saline was given by intravenously (IV). 12.4 ml/kg intralipid emulsion was given to the second group by IV route. ½ LD50 pioglitazone (1000 mg/kg) per oral (PO) followed by 12.4 ml/kg normal saline IV was given to the third group. ½ LD50 pioglitazone (1000 mg / kg) PO followed by 12.4 ml / kg intralipid emulsion IV was then given to the fourth group. After 24 hours, rats were decapitated and tissue samples were taken for histopathological examination. Results: The histopathological scores of liver tissue in the third and fourth groups were significantly higher than the other groups. The histopathological scores of the kidney tissue were significantly higher in the second, third and fourth groups compared to the control group. The histopathological scores of the heart tissue were examined, no statistically significant difference was found in our model. ILE itself were found toxic to kidney cells. Conclusion: Although toxic effects can be observed in the liver and kidney tissues due to pioglitazone usage, intralipid emulsion treatment is insufficient to reverse these toxic effects. Toxic effects can be seen in the kidney tissue due to intralipid treatment and studies on different doses and timing are needed. Keywords: Pioglitazone, intravenous lipid emulsion, intoxication, animal model

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Section: Discussionsupporting

confidence: 92%

Histopathological Changes with Acute Pioglitazone Intoxication and the Effects of Intralipid Emulsion Treatment in Rats

Taşçı,

Ak,

Taşçı

et al. 2024

Preprint

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“…20 Ml Ampul for Infusion, İlaçsan ® /Turkey), ILE (ClinOleic 20% lipid 500 mL, ECZACIBAŞI Baxter/Belgium), and 0.9% NaCl were administered with an infusion pump (Swiss Made, Arcomed AG Volumed VP 7000, Kloten, Switzerland). The medication dosages and administration methods were determined and the experimental protocol was designed based on the study reports in the literature and references explained previously [8,13,14].…”

Section: Methodsmentioning

confidence: 99%

The Effects of Intravenous Lipid Emulsion Therapy in the Prevention of Depressive Effects of Propofol on Cardiovascular and Respiratory Systems: An Experimental Animal Study

Doğanay

Ak²,

Alışkan

et al. 2018

Medicina

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Background and objectives: Although there are several hypotheses about the mechanism of action, intravenous lipid emulsion (ILE) therapy has been shown to be effective in the treatment of toxicities due to local anaesthetics and many lipophilic drugs. In this study, we had hypothesized that ILE therapy might also be effective in preventing mortality and cardiorespiratory depressant effects due to propofol intoxication. Materials and methods: Twenty-eight Sprague-Dawley adult rats were randomly divided into four groups. Saline was administered to the subjects in the control group. The second group was administered propofol (PP group); the third group was administered ILE (ILE group), and the fourth group was administered propofol and ILE therapy together (ILE+PP group). Systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory rate (RR), heart rate (HR), and mortality were recorded at 10 time-points during a period of 60 min. A repeated measures linear mixed-effect model with unstructured covariance was used to compare the groups. Results: In the PP group; SBP, DBP, RR, and HR levels declined steadily; and all rats in this group died after the 60-min period. In the ILE+PP group, the initially reduced SBP, DBP, RR, and HR scores increased close to the levels observed in the control group. The SBP, DBP, RR, and HR values in the PP group were significantly lower compared to the other groups (p < 0.01). The mortality rate was 100% (with survival duration of 60 min) for the PP group; however, it was 0% for the remaining three groups. Conclusions: Our results suggest that the untoward effects of propofol including hypotension, bradycardia, and respiratory depression might be prevented with ILE therapy.

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“…Dosages, drug application methods and experimental protocols were determined according to the previous studies and the mentioned sources [8,13,14].…”

Section: Experiments Protocol and Groupsmentioning

confidence: 99%

The Effects of Intravenous Lipid Emulsion Therapy in the Prevention of Depressive Effects of Propofol on Cardiovascular and Respiratory Systems: An Experimental Animal Study

Doğanay

Ak²,

Alışkan

et al. 2018

Preprint

Self Cite

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Background and objective: Propofol is an anesthetic agent that is frequently used in anesthesia induction, maintenance and sedation. Propofol has severe side effects such as hypotension, bradycardia and respiratory depression. Although propofol is commonly used, there is no known antidote for its toxic effects. An approach to prevent toxic effects of propofol would be beneficial. The aim of this study was to assess the effects of intravenous lipid emulsion (ILE) therapy in the prevention of depressive effects of propofol on cardiovascular and respiratory systems. Materials and methods: Twenty-eight Sprague-Dawley adult rats were randomly divided into 4 groups. The saline-administered group was determined as the Control group. The second group was administered propofol (PP group); the third group was administered ILE (ILE group), and the fourth was administered propofol with ILE therapy (ILE+PP group). Systolic blood pressure (SBP), Diastolic blood pressure (DBP), Mean arterial blood pressure (MAP), Respiratory rate (RR), Heart rate (HR) and mortality were recorded at 10 points during 60 minutes. A repeated measures linear mixed-effect model with unstructured covariance was used to compare the groups. Results: In the PP group, SBP, DBP, MAP, RR and HR levels were declining steadily; all rats in this group died after 60 minutes. In the ILE+PP group, after a while, the decreased SBP, DBP, MAP, RR and HR levels increased SBP, DBP, MAP, RR and HR levels of the Propofol group were found to be significantly lower than those of the other groups (p<0.01). The mortality rate was 100% (surviving period, 60 min) for the PP group, whereas 0% for the ILE, ILE+PP and Control groups. Conclusion: Our results suggest that undesirable side effects that can be seen after propofol application such as hypotension, bradycardia and respiratory depression might be prevented by using ILE therapy.

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The Role of Intralipid Emulsion in the Rat Model of Digoxin Intoxication

Cited by 10 publications

References 28 publications

Histopathological Changes with Acute Pioglitazone Intoxication and the Effects of Intralipid Emulsion Treatment in Rats

Histopathological Changes with Acute Pioglitazone Intoxication and the Effects of Intralipid Emulsion Treatment in Rats

The Effects of Intravenous Lipid Emulsion Therapy in the Prevention of Depressive Effects of Propofol on Cardiovascular and Respiratory Systems: An Experimental Animal Study

The Effects of Intravenous Lipid Emulsion Therapy in the Prevention of Depressive Effects of Propofol on Cardiovascular and Respiratory Systems: An Experimental Animal Study

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