The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck

Bloom, David C.; Goldfarb, P. M.

doi:10.1016/j.ejso.2005.04.007

Cited by 56 publications

(48 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In multicenter Phase II studies, 51 recurrent tumors were treated in 42 patients [60]. There was an increase in survival from 3 to 6.4 months in patients treated with intralesional bleomycin plus EPT.…”

Section: Electroporation Therapy In Head and Neck Cancermentioning

confidence: 97%

Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors

Byrne¹,

Thompson²

2006

Expert Review of Anticancer Therapy

View full text Add to dashboard Cite

Electroporation is a novel therapeutic modality that uses pulsed electrical currents to enhance the uptake of drugs, vaccines and genes into cells, and has been used for over 20 years. Electroporation therapy using cytotoxic drugs is called electrochemotherapy. Electrochemotherapy has been studied in vitro, in vivo and in clinical trials. It is potentially useful for treating patients with metastatic tumors, such as melanoma, and even select primary tumors, such as head and neck squamous cell carcinomas and basal cell carcinoma. Various chemotherapeutic agents have been tested with electroporation therapy, but bleomycin and cisplatin are the two most widely used. The biological basis of electroporation therapy is outlined in this review and basic science studies and the limited clinical studies that have involved electrochemotherapy are reviewed. Particular focus is placed on trials involving melanoma, head and neck cancers and other primary and metastatic skin cancers.

show abstract

Section: Electroporation Therapy In Head and Neck Cancermentioning

confidence: 97%

Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors

Byrne¹,

Thompson²

2006

Expert Review of Anticancer Therapy

View full text Add to dashboard Cite

show abstract

“…Preclinical developments before the use of electrochemotherapy first in human patients, and subsequent research, helped define its mechanism of action, the most effective treatment parameters, both electrical and pharmacological, and the most suitable operating procedures for safe and reproducible treatments. Electrochemotherapy has been repeatedly and independently shown to be highly effective in providing local tumor control and palliation of symptomatic lesions located in cutaneous or subcutaneous tissues regardless of their histological origin, while maintaining a very low toxicity profile and high patient acceptance [40][41][42][43][44][45][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65].…”

Section: Resultsmentioning

confidence: 99%

“…In the bleomycin with electrochemotherapy groups, 17 tumors showed CR, 22 tumors showed a PR and 30 failed to achieve more than a 50% reduction in tumor size (no response) with 57% overall OR rate. Electrochemotherapy with bleomycin had a significantly (t-test; P < 0.001) greater number of patients showing a PR or CR to the therapy when compared with bleomycin alone [64].…”

Section: Electrochemotherapy In the Treatment Of Head And Neck Cancermentioning

confidence: 97%

Electrochemotherapy for primary skin cancer and skin metastasis related to other malignancies

Reinhold

2011

Anti-Cancer Drugs

View full text Add to dashboard Cite

Electrochemotherapy is an effective local tumor ablation modality in the treatment of solid cancers. Its use combines the administration of nonpermeable or poorly permeable highly intrinsic cytotoxic drugs with the application of short and intense electric pulses to the tumors to facilitate the drug delivery into the cancer cells. After several preclinical and clinical studies using different and nonhomogenous protocols, the results of the multicenter European Standard Operating Procedure of Electrochemotherapy (ESOPE) project provided clinical procedures for a standardized, efficient, and safe electric pulse and drug administration protocol for the local treatment of any type of skin tumor nodules. Additional studies using the the multicenter European Standard Operating Procedure of Electrochemotherapy standard operating procedures confirmed the overall clinical results obtained. Currently, the tumors most frequently treated with ECT are melanoma and breast cancer metastasis, but also head and neck cancer, primary tumors of the skin, and Kaposi sarcoma. This review is intended as an update on the therapy and as an indication of possible future developments.

show abstract

“…33,34 Studies have shown that RE in combination with bleomycin therapy is safe and improves outcomes for the treatment of squamous cell carcinoma of the head and neck when compared with bleomycin therapy alone. 35,36 …”

Section: Reversible Electroporationmentioning

confidence: 99%

Irreversible Electroporation for the Ablation of Liver Tumors

Charpentier¹

2012

Arch Surg

View full text Add to dashboard Cite

The role of intratumour therapy with electroporation and bleomycin in the management of advanced squamous cell carcinoma of the head and neck

Cited by 56 publications

References 15 publications

Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors

Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors

Electrochemotherapy for primary skin cancer and skin metastasis related to other malignancies

Irreversible Electroporation for the Ablation of Liver Tumors

Contact Info

Product

Resources

About