The Role of Intravascular Clotting in the Etiology of Shock

Hardaway, Col Robert M.

doi:10.1097/00000658-196203000-00001

Cited by 92 publications

(17 citation statements)

References 19 publications

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“…This treatment was attended by a decrease in the screen filtration pressure of the blood to or below normal. 4. The increase in screen filtration pressure which occurred during hypotension was much less marked if the animals' blood had first been circulated through pyrex glass wool.…”

Section: Discussionmentioning

confidence: 97%

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Alteration of Blood During Acute Hypotension: Effect of Continuous Glass Wool Filtration

Swank

Isselhard

Hissen

et al. 1964

Circulation Research

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Acute hypotension was produced in heparinized and nonheparinized dogs by hemorrhage and by injections of histamine, and adhesiveness and aggregation of blood elements determined periodically by the screen filtration pressure method. This method measures the pressure required to force blood at a constant rate through a standardized screen with multiple square holes each 20 x 20 micra. In some cases the arterial blood was perfused through a glass wool filter in an extracorporeal system both before and during periods of hypotension. The results of these studies justify the following conclusions: 1. Increased adhesiveness and aggregation of platelets and other blood elements which occur during hypotension produced by hemorrhage or intravenous injections of histamine were indicated by an increase in the screen filtration pressure of blood. These changes were not prevented from developing, or significantly altered by heparinization of the animal. 2. The amount of blood which could be obtained during arterial hemorrhage was significantly increased by heparinization of the animal. 3. The adhesive and aggregated platelets and leucocytes, which formed during hypotension, were removed from the blood when it was perfused through a column of glass wool. This treatment was attended by a decrease in the screen filtration pressure of the blood to or below normal. 4. The increase in screen filtration pressure which occurred during hypotension was much less marked if the animals' blood had first been circulated through pyrex glass wool. 5. Filtration of blood through pyrex glass wool was also attended by a progressive decrease in the mean arterial blood pressure of the animal.

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Section: Discussionmentioning

confidence: 97%

“…Crowell and Read 3 and Hardaway 4 studied the clotting mechanisms of the blood during acute hypotension due to bleeding. They noted an increased tendency to coagulation of the blood, which was lessened, but not abolished by intravenous heparin injections.…”

Section: Discussionmentioning

confidence: 99%

Alteration of Blood During Acute Hypotension: Effect of Continuous Glass Wool Filtration

Swank

Isselhard

Hissen

et al. 1964

Circulation Research

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“…It was also postulated that DIG might occur in preterm infants resulting in hemorrhage. The hypothesis was based on animal studies [11][12][13][14][15] which closely resembled the condition found in pre term infants and on preliminary human data.…”

Section: Discussionmentioning

confidence: 99%

Hypercoagulability in Premature Infants with Special Reference to the Respiratory Distress Syndrome and Hemorrhage

Markarian¹,

Lo²,

Rosenblut³

et al. 1971

Neonatology

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“…(4) Thrombosis of the minute vessels -the development of thrombi in the minute vessels of the circulatory system caused by sluggish blood flow and the action of metabolic acids (carbonic or lactic).…”

Section: Causes For Progression Of Shockmentioning

confidence: 99%

“…(3) To perform research and engineering in instrumentation and measurement in support of the above. (4) To perform research and engineering in order to achieve maximum immunity of systems to adverse influences, including countermeasures, nuclear radiation, battlefield conditions, and high-altitude and space environments. (5) To perform research and engineering on materials, components, and subsystems in support of above.…”

mentioning

confidence: 99%

A Proposal for the Dynamic Analysis of Circulatory Shock

Woodward¹,

Barila²

1963

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MISSIONThe mission of the Harry Diamond Laboratories is:(1) To perform research and engineering on systems for detecting, locating, and evaluating targets; for accomplishing safing, arming, and munition control functions; and for providing initiation signals: these systems include, but are not limited to, radio and non-radio proximity fuzes, predictor-computer fuzes, electronic timers, electrically-inLtiated fuzes, and related items.( 2) To perform research and engineering in fluid amplification and fluid-actuated control systems.To perform research and engineering in instrumentation and measurement in support of the above. (4) To perform research and engineering in order to achieve maximum immunity of systems to adverse influences, including countermeasures, nuclear radiation, battlefield conditions, and high-altitude and space environments. (5)To perform research and engineering on materials, components, and subsystems in support of above. (6) To conduct basic research in the physical sciences in support of the above. (7) To provide consultative services to other Government agencies when requested. (8) To carry out special projects lying within installation competence upon approval by the Director of Research and Development, Army Materiel Command. (9) To maintain a high degree of competence in the application of the physical sciences to the solution of military problems.The findings in this report are not to be construed as an official Department of the Army position.

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The Role of Intravascular Clotting in the Etiology of Shock

Cited by 92 publications

References 19 publications

Alteration of Blood During Acute Hypotension: Effect of Continuous Glass Wool Filtration

Alteration of Blood During Acute Hypotension: Effect of Continuous Glass Wool Filtration

Hypercoagulability in Premature Infants with Special Reference to the Respiratory Distress Syndrome and Hemorrhage

A Proposal for the Dynamic Analysis of Circulatory Shock

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