The Role of Invasive Diagnostic Testing in Inflammatory Eye Diseases

Park, Susanna Soon Chun; D’Amico, Donald J.; Foster, C S

doi:10.1097/00004397-199403430-00021

Cited by 7 publications

(3 citation statements)

References 0 publications

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“…Although ocular tissue can be obtained via vitreous or aqueous aspiration, external chorioretinal biopsy, transvitreal retinal, subretinal, or chorioretinal biopsy, a complete diagnostic vitrectomy is the preferred method 7,8,12. Chorioretinal biopsy may be associated with more complications 7 whereas vitreous or anterior chamber taps may lead to insufficient and hypocellular samples leading to low diagnostic yield 13,14. For eyes with solitary subretinal lesions without vitreous cells, a subretinal aspiration biopsy could be considered 15.…”

Section: Introductionmentioning

confidence: 99%

Primary Intraocular Lymphoma: Diagnosis and Differential Diagnosis

Sen

Bodaghi

Hoang

et al. 2009

Ocular Immunology and Inflammation

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Diagnosis of PIOL can be challenging. It requires a high degree of clinical suspicion and differential diagnosis includes infectious and non-infectious etiologies particularly the common masquaraders sarcoidosis, tuberculosis, viral retinitis and syphilis. The definitive diagnosis depends on demonstration of malignant lymphoma cells in ocular specimens or CSF. Ocular specimen could include vitreous, aqueous or chorioretinal biopsy. Ocular pathologist should be consulted prior to the diagnostic procedure to help handle and process the specimen appropriately. In addition to cytology, flow cytometry, immunohistochemistry, molecular analysis and cytokines may be used as adjuncts in facilitating the diagnosis.

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Section: Introductionmentioning

confidence: 99%

Primary Intraocular Lymphoma: Diagnosis and Differential Diagnosis

Sen

Bodaghi

Hoang

et al. 2009

Ocular Immunology and Inflammation

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“…Retinal biopsy is a radical procedure fraught with complications (vitreous hemorrhage, retinal detachment, hypotony) that is recommended for patients like ours in whom a sight-threatening retinitis is not responding to therapy. 13 The biopsy specimen demonstrated large numbers of silver-staining bacteria consistent with B henselae using the Steiner variation of the Warthin-Starry stain. This finding is in agreement with results of previous investigations showing that this staining procedure detects B henselae.…”

Section: Commentmentioning

confidence: 96%

Use of Retinal Biopsy to Diagnose Bartonella (Formerly Rochalimaea) henselae Retinitis in an HIV-Infected Patient

Warren

Goldstein²,

Hung³

et al. 1998

Arch Ophthalmol

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“…In the majority of cases, the slit-lamp biomicroscopic and ophthalmoscopic appearance of the vitreous, retina, and choroid is diagnostic of a specific disorder, especially when combined with the findings from ancillary tests such as fluorescein angiography, ocular echography, and radiologic and serologic tests. 3 In most of these cases, therapeutic intervention will be either antimicrobial, antineoplastic, or anti-inflammatory. The inability to make a specific diagnosis has been reported in up to 33% of patients who present with intraocular inflammation.…”

Section: Introductionmentioning

confidence: 99%