The Role of Ischemic Preconditioning in the Recruitment of Rolling and Adherent Leukocytes in Hepatic Venules after Ischemia/Reperfusion

Ischemic Preconditioning and Liver Tolerance to Warm or Cold Ischemia: Experimental Studies in Large Animals

“…Our data are consistent with previous observations in murine models in which leukocyte-endothelial cell interactions and liver damage were significantly decreased in animals undergoing IPC (31,39). Ischemia-reperfusion injury is exacerbated by a nonspecific inflammatory response afforded by the complex interaction of humoral and cellular inflammatory mediators.…”

“…The potential effect of IPC was initially explored in the heart by evaluating its ability to reduce the size of a myocardial infarction (6). Subsequently, the protective effect of ischemic preconditioning has been well documented in a variety of tissues and organs including the liver (7)(8)(9)(11)(12)(13)17,19,31). This study confirms ischemic preconditioning in the liver during normothermic ischemia and reperfusion and extends these observations to the large animal in addition to rodent models.…”

Modulation of liver oxidant-antioxidant system by ischemic preconditioning during ischemia/reperfusion injury in rats

“…Neutrophils contribute to the hepatic I/R injury [13] . Intravital video microscopy observed that ischemic pre-conditioning could attenuate the recruitment of leukocytes in terminal hepatic venules after liver I/R [14] . Our study also showed that IPC significantly blunted the increase of liver MPO contents, a marker of neutrophils accumulation, compared with I/R group.…”

Microvascular graft dysfunction

“…Our current understanding of the underlying biologic principle is that cells primed by various kinds of subinjurious stress trigger defense mechanisms against subsequent lethal injury of the same or different type. The protective effects of ischemic preconditioning on hepatic microcirculation have been studied recently in animal models [13,14]. Improved microcirculation either might be the result of or the reason for the preserved parenchymal architecture.…”