The role of JAK/STAT signaling pathway and TNF-α crosstalk in human colorectal cancer

Erkasap, Nilüfer; Özyurt, Rumeysa; Özkurt, Mete; Yaşar, Fatih; Erkasap, Serdar; İhtiyar, Enver

doi:10.1016/j.genrep.2016.01.002

Cited by 8 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Novel PKC inhibitors have been shown to mediate UV-induced MMP-1 expression in a previous study [25]. JAK2 and PKCδ are involved in not only skin aging but also oncogenic alterations such as cell survival, proliferations, and invasion [23,26]. For these reasons, our results carefully suggest that the anti-cancer effect of quercetin may be partly related to the inhibition of JAK2 and PKCδ.…”

Section: Discussionsupporting

confidence: 59%

Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin

Shin

Lee

Hong

et al. 2019

IJMS

View full text Add to dashboard Cite

Quercetin is a naturally occurring polyphenol present in various fruits and vegetables. The bioactive properties of quercetin include anti-oxidative, anti-cancer, anti-inflammatory, and anti-diabetic effects. However, the effect of quercetin on skin aging and the direct molecular targets responsible have remained largely unknown. Herein, we investigated the protective effect of quercetin against UV-mediated skin aging and the molecular mechanisms responsible. Treatment with quercetin suppressed UV-induced matrix metalloproteinase-1 (MMP-1) and cyclooxygenase-2 (COX-2) expression and prevented UV-mediated collagen degradation in human skin tissues. Quercetin exerted potent inhibitory effects towards UV-induced activator protein-1 (AP-1) and nuclear factor-kappa B (NF-κB) activity. Further examination of the upstream signaling pathways revealed that quercetin can attenuate UV-mediated phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N terminal kinases (JNK), protein kinase B (Akt), and signal transducer and activator of transcription 3 (STAT3). Kinase assays using purified protein demonstrated that quercetin can directly inhibit protein kinase C delta (PKCδ) and Janus kinase 2 (JAK2) kinase activity. Quercetin was observed to bind to PKCδ and JAK2 in pull-down assays. These findings suggest that quercetin can directly target PKCδ and JAK2 in the skin to elicit protective effects against UV-mediated skin aging and inflammation. Our results highlight the potential use of quercetin as a natural agent for anti-skin aging applications.

show abstract

Section: Discussionsupporting

confidence: 59%

Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin

Shin

Lee

Hong

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…The NOX1-derived ROS generation stimulates Wnt/β-catenin and Notch signaling pathway thereby, enhancing cell proliferation [351,352] and gain resistance towards apoptosis. Redox modifications of protein cysteine residues in CRC development may involve with signaling pathway and transcriptional factors modulators [353] such as Sp [342], NF-κB [354,355,356], p53 [357,358,359,360], HIF-1α [361,362], and Nrf2 transcription factor [342,363,364,365], c-Myc [351], MAPK cascade [366,367,368], PI3K/AKT [369,370,371], and janus kinases/signal transducer and activator of transcription proteins (JAK/STAT) signaling pathway [358,372].…”

Section: Molecules Target and Signaling Pathway Of Apoptosis Inducmentioning

confidence: 99%

Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer

Ismail

Othman

Abas

et al. 2019

IJMS

124

View full text Add to dashboard Cite

Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new cases by the year 2030. The current treatment modalities with the usage of chemo drugs such as FOLFOX and FOLFIRI, surgery and radiotherapy, which are usually accompanied with major side effects, are rarely cured along with poor survival rate and at higher recurrence outcome. This trigger the needs of exploring new natural compounds with anti-cancer properties which possess fewer side effects. Curcumin, a common spice used in ancient medicine was found to induce apoptosis by targeting various molecules and signaling pathways involved in CRC. Disruption of the homeostatic balance between cell proliferation and apoptosis could be one of the promoting factors in colorectal cancer progression. In this review, we describe the current knowledge of apoptosis regulation by curcumin in CRC with regard to molecular targets and associated signaling pathways.

show abstract

“…In addition, ROS can activate the CRC-related JAK/STAT pathway as well. For example, Sang-Kyu Park demonstrated that short time of H 2 O 2 stimulation induced the activation of STAT pathway by phosphorylation of the Tyr705 of STAT3, which induced the overexpression of cyclinD1 and inhibition of CRC cell apoptosis 80 - 82 (Fig. 4 ).…”

Section: The Relation Between Oxidative Stress and Crcmentioning

confidence: 99%

Redox Imbalance in the Development of Colorectal Cancer

et al. 2017

View full text Add to dashboard Cite

Redox imbalance is resulted from the destruction of balance between oxidants and antioxidants. The dominant oxidants are reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins. Generally speaking, low concentration of ROS is indispensable for cell survival and proliferation. However, high concentration of ROS is cytotoxic. Additionally, ROS are now known to induce the oxidative modification of macromolecules especially proteins. The redox modification of proteins is involved in numerous biological processes related to diseases including CRC. Herein, we attempt to afford an overview that highlights the crosstalk between redox imbalance and CRC.

show abstract

The role of JAK/STAT signaling pathway and TNF-α crosstalk in human colorectal cancer

Cited by 8 publications

References 11 publications

Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin

Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin

Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer

Redox Imbalance in the Development of Colorectal Cancer

Contact Info

Product

Resources

About