The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix

Liu, Eric; Telem, Dana A.; Warner, Richard R.P.; Dikman, Andrew; Divino, Celia M.

doi:10.1016/j.amjsurg.2010.08.036

Cited by 31 publications

(21 citation statements)

References 19 publications

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“…The Ki-67 staining was relatively low in Group A (11%) and B (18%) tumors, and Group C (80%) tumors demonstrated a high proliferative rate [5]. However, more recent study has shown no correlation between the Ki-67 and the behavior of the GCC tumors [23].…”

Section: Discussionmentioning

confidence: 90%

“…This two-tier grading system demonstrated that the overall 10-year survival rate in the low-grade histology group was 80.5%, and 0% in the highgrade histology group. However, the role of Ki-67 as a prognostic marker has been controversial [5,18,[20][21][22][23]. The Ki-67 proliferative index has shown close association with the Tang histologic classification.…”

Section: Discussionmentioning

confidence: 99%

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Adenocarcinoma Ex Goblet Cell Carcinoid (GCC) of the Appendix: Report of Five Cases and Pitfalls in Diagnosis of GCC

Piao¹,

Veerapong²,

Li³

et al. 2016

Arch Surg Oncol

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Neoplasm of the appendix is relatively rare. Only 0.9-1.4% of all appendectomy specimens is found to have it. One in particular is the adenocarcinoma ex goblet cell carcinoid. The exact histopathogenesis and pathologic classification of this neoplasm are yet to be elucidated. Herein we report five cases to emphasize the importance of meticulous sampling and the possibility of misdiagnosis due to the presence of diverticulitis and acute appendicitis in some of these patients. All of our patients initially were presented with symptoms of or mimicking appendicitis, with radiology imaging suggestive of acute appendicitis or an appendiceal abscess. The pathologic examination of the appendectomy specimen revealed the incidental finding of the adenocarcinoma ex goblet cell carcinoid with focal positivity of synaptophysin and chromogranin. Two of our patients had diverticulitis and perforated appendicitis, which may lead to a misdiagnosis of the goblet cell carcinoid due to the absence of a discrete mass formation and focal localization of these tumor cells. Therefore, meticulous sampling is imperative in the diagnosis of this entity.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma Ex Goblet Cell Carcinoid (GCC) of the Appendix: Report of Five Cases and Pitfalls in Diagnosis of GCC

Piao¹,

Veerapong²,

Li³

et al. 2016

Arch Surg Oncol

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“…The role of Ki67 in GCC is uncertain, and the literature suggests no predictive value with respect to patient outcome [12]. The median Ki67 in reported series of appendiceal GCC was between 27.9 and 32% [11,42].…”

Section: Discussionmentioning

confidence: 99%

“…The value of Ki67 estimation (commonly used to determine proliferative activity in NETs) in GCC remains uncertain, with reports that suggest no impact on patient outcome [12]. Serum biomarkers, serum chromogranin-A and 5-HIAA (5-hydroxyindoleacetic acid), also widely employed in the management of NETs, are negative in the majority of GCC patients [13].…”

Section: Introductionmentioning

confidence: 99%

Appendiceal Goblet Cell Carcinoids: Management Considerations from a Reference Peritoneal Tumour Service Centre and ENETS Centre of Excellence

Lamarca¹,

Nonaka²,

Escola³

et al. 2015

Neuroendocrinology

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Background: Appendix goblet cell carcinoids are known to share histological features of adenocarcinoma and neuroendocrine tumours. Due to their low incidence, quality evidence is lacking for the management of these patients. Methods: We performed a single-centre retrospective study of patients with a confirmed diagnosis of appendiceal goblet cell carcinoid (GCC; 1996-2014). Patients were divided into curative intent (CI) and palliative intent (PI) cohorts. Our primary end point was overall survival (OS). Results: Seventy-four patients were eligible; 76% were treated with CI [surgery only (36%), cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC; 36%), adjuvant chemotherapy (20%) and a combination of CRS and HIPEC followed by adjuvant chemotherapy (9%)], and 23% had advanced-stage disease amenable to palliative treatment (chemotherapy or supportive care) only. Completion right hemicolectomy, performed in 64% of the CI cohort, did not impact on the relapse rate or disease-free survival. FOLFOX chemotherapy was used in both the adjuvant and palliative settings; safety was as expected, and we observed a high rate (60%) of disease control in the palliative cohort. The estimated median OS (all patients), disease-free survival (CI patients) and progression-free survival (PI patients) were 52.1 (95% CI 29.4-90.3), 75.9 (26.6-not reached) and 5.3 (0.6-5.7) months, respectively. Age and stage were independent factors associated with OS in the multivariable analysis. Tang classification showed a trend for impact on OS. No benefit from specific adjuvant approach was identified; however, selection bias for treatment approach was observed. Conclusion: Prospective trials are needed to define optimal approaches in GCC. All GCC patients should be managed by specialized centres due to their esoteric behaviour; we provide management considerations based on our experience and conclusions.

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“…Cells express Ki67 during the G1, S, G2, and M phases but not during the resting phase, G0 (Beresford et al , 2006). The Ki67 labelling index is an independent predictor of disease progression and recurrence in carcinomas including melanoma, and it is used as a grade index and prognostic marker (Cheang et al , 2009; Yerushalmi et al , 2010; Liu et al , 2011; Vaisanen et al , 2011). Ki67 is highly overexpressed in a number of cancers including melanoma.…”

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confidence: 99%

Potent anti-tumour activity of a novel conditionally replicating adenovirus for melanoma via inhibition of migration and invasion

Jiang

et al. 2014

Br J Cancer

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Background:Conditionally replicating adenoviruses (CRAds) represent a novel class of oncological therapeutic agents. One strategy to ensure tumour targeting is to place the essential viral genes under the control of tumour-specific promoters. Ki67 has been selected as a cancer gene therapy target, as it is expressed in most malignant cells but is barely detectable in most normal cells. This study aimed to investigate the effects of a Ki67 promoter-controlled CRAd (Ki67-ZD55-IL-24) on the proliferation and apoptosis of melanoma cells.Methods:Melanoma cells were independently treated with Ki67-ZD55-IL-24, ZD55-IL-24, Ki67-ZD55, and ZD55-EGFP. The cytotoxic potential of each treatment was assessed using cell viability measurements. Cell migration and invasion were assayed using cell migration and invasion assays. Apoptosis was assayed using the annexin V-FITC assay, western blotting, reverse transcriptase PCR (RT–PCR), haematoxylin and eosin (H&E) staining, and the TUNEL assay.Results:Our results showed that Ki67-ZD55-IL-24 had significantly enhanced anti-tumour activity as it more effectively induced apoptosis in melanoma cells than the other agents. Ki67-ZD55-IL-24 also caused the most significant inhibition of cell migration and invasion of melanoma cells. Furthermore, apoptosis was induced more effectively in melanoma xenografts in nude mice.Conclusions:This strategy holds promising potential for the further development of an effective approach to treat malignant melanoma.

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The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix

Cited by 31 publications

References 19 publications

Adenocarcinoma Ex Goblet Cell Carcinoid (GCC) of the Appendix: Report of Five Cases and Pitfalls in Diagnosis of GCC

Adenocarcinoma Ex Goblet Cell Carcinoid (GCC) of the Appendix: Report of Five Cases and Pitfalls in Diagnosis of GCC

Appendiceal Goblet Cell Carcinoids: Management Considerations from a Reference Peritoneal Tumour Service Centre and ENETS Centre of Excellence

Potent anti-tumour activity of a novel conditionally replicating adenovirus for melanoma via inhibition of migration and invasion

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