The Role of Kisspeptin in the Onset of Puberty and in the Ovulatory Mechanism: A Mini-review

Cortés, Manuel E.; Carrera, B; Rioseco, Hernán; Río, Juan Pablo del; Vigil, Pilar

doi:10.1016/j.jpag.2014.09.017

Cited by 48 publications

(33 citation statements)

References 48 publications

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“…Through WGBS, 268 DMR and 117 differentially methylated genes were found in the hypothalamus genome, and we identified different DNA methylation patterns from prepuberty to puberty. Two genes, GnRH and KISS1 , which play important roles in the onset of puberty[9–11], showed no changes in methylation patterns in the present study. A differential methylation profile of the KISS1 promoter has previously been demonstrated[25], and previous studies have indicated that the methylation of CpG sites in the promoter of the gene body of the GnRH gene showed decreased patterns across puberty[26, 27].…”

Section: Discussioncontrasting

confidence: 56%

“…Several studies have indicated that the reactivation of GnRH secretion with pubertal initiation may be associated with downregulation of the Makorin ring finger 3 gene ( MKRN3 )[2, 3, 6–8]. Kisspeptin, a GnRH agonist encoded by the KISS1 gene, also plays an essential role in regulating the timing of puberty[9–11]. In female rodents, kisspeptin neurons in the anteroventral periventricular nucleus are critical for GnRH positive feedback regulation[12–14].…”

Section: Introductionmentioning

confidence: 99%

“…In female rodents, kisspeptin neurons in the anteroventral periventricular nucleus are critical for GnRH positive feedback regulation[12–14]. In addition, monogenic mutations in several genes, including KISS1 , MKRN , TAC3 (tachykinin 3), and GPR54 (G-protein-coupled receptor 54) have also been associated with pubertal initiation failure[9, 10, 15–17]. Furthermore, several central nodes have been identified in previous reports, including the zinc finger–containing gene EAP1 (enhanced at puberty 1), the POU-domain gene Oct2 and the homeodomain gene TFT1 [1, 5].…”

Section: Introductionmentioning

confidence: 99%

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DNA Methylation Patterns in the Hypothalamus of Female Pubertal Goats

Yang

et al. 2016

PLoS ONE

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Female pubertal development is tightly controlled by complex mechanisms, including neuroendocrine and epigenetic regulatory pathways. Specific gene expression patterns can be influenced by DNA methylation changes in the hypothalamus, which can in turn regulate timing of puberty onset. In order to understand the relationship between DNA methylation changes and gene expression patterns in the hypothalamus of pubertal goats, whole-genome bisulfite sequencing and RNA-sequencing analyses were carried out. There was a decline in DNA methylation levels in the hypothalamus during puberty and 268 differentially methylated regions (DMR) in the genome, with differential patterns in different gene regions. There were 1049 genes identified with distinct expression patterns. High levels of DNA methylation were detected in promoters, introns and 3′-untranslated regions (UTRs). Levels of methylation decreased gradually from promoters to 5′-UTRs and increased from 5′-UTRs to introns. Methylation density analysis demonstrated that methylation level variation was consistent with the density in the promoter, exon, intron, 5′-UTRs and 3′-UTRs. Analyses of CpG island (CGI) sites showed that the enriched gene contents were gene bodies, intergenic regions and introns, and these CGI sites were hypermethylated. Our study demonstrated that DNA methylation changes may influence gene expression profiles in the hypothalamus of goats during the onset of puberty, which may provide new insights into the mechanisms involved in pubertal onset.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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DNA Methylation Patterns in the Hypothalamus of Female Pubertal Goats

Yang

et al. 2016

PLoS ONE

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“…Leptin therefore may serve as an upstream biomarker for the onset of puberty. Together with evidence that kisspeptin acts as a key gating factor in puberty (Clarke, Dhillo, & Jayasena, ; Cortes, Carrera, Rioseco, Pablo del Rio, & Vigil, ) and in regulation of HPG activity (Chan et al., ; de Roux et al., ), these findings suggest that both kisspeptin and leptin could prove useful in tracking pubertal onset, including delayed or precocious puberty, although the work in humans is preliminary and based on clinical populations (Lippincott et al., ). Insofar as leptin and the expression of kisspeptins are influenced by stress, nutrition, obesity and other metabolic disruptions, they may be useful probes to examine multisystemic effects of health and well‐being on pubertal development.…”

Section: Methodological Advancesmentioning

confidence: 86%

Puberty and the Evolution of Developmental Science

Worthman

Dockray

Marceau

2019

J of Research on Adolesc

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In recent decades, theoretical and methodological advances have operated synergistically to advance understanding of puberty and prompt increasingly comprehensive models that engage with the temporal, psychosocial, and biological dimensions of this maturational milepost. This integrative overview discusses these theoretical and methodological advances and their implications for research and intervention to promote human development in the context of changing maturational schedules and massive ongoing social transformations.Funding: AA022919-01, HD073033, MH083964-01 (CMW); K01 DA039288 (KM).Author contributions: Worthman deploys a biocultural approach in comparative interdisciplinary research on human development and pathways to differential mental and physical health. She has conducted comparative biosocial research in thirteen countries, as well as in rural, urban, and semi-urban areas of the United States. Dockray's research focuses on psychobiological mechanisms to understand how experiences and emotions affect adolescent health and behavior. Her work concentrates on how the experiences of everyday life relate to psychoneuroendocrine processes and health-related behaviors during adolescence. Marceau conducts developmental research incorporating the integrated roles of genetics, prenatal risk, neuroendocrine development, and the family environment to examine the role of biobehavioral developmental pathways and interactions in adolescent behavior problems and substance use across the lifespan.Requests for reprints should be sent to Carol M. Worthman,

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“…Later on, when a follicle becomes the dominant follicle, it produces increasingly high levels of estradiol, which result in a stimulation of kisspeptinergic neurons in the anteroventral periventricular nucleus of the hypothalamus, thus changing the negative feedback mechanism to a positive one. Kisspeptin induces GnRH secretion and the following pre-ovulatory LH peak, which initiates follicular luteinization that leads to the formation of the corpus luteum (Cortés et al 2015). After the initiation of the midcycle gonadotrophin surge, a pre-ovulatory rise in progesterone occurs.…”

Section: Endocrine Regulation Of the Ovulatory Cyclementioning

confidence: 99%

Ovulation, A Sign of Health

Vigil

Lyon²,

Flores³

et al. 2017

Linacre Q

Self Cite

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The concept of the ovarian continuum can be understood as a process that occurs during a woman's lifetime and begins during intrauterine life with fertilization. Women start their reproductive years with approximately five hundred thousand follicles containing oocytes, of which only around five hundred will be released during ovulation. Ovulation has been recognized as an event linked with reproduction; however, recent evidence supports the role of ovulation as a sign of health. The use of biomarkers that help women recognize ovulation enables them to identify their health status. This knowledge helps medical healthcare providers in the prevention, diagnosis, and treatment of different pathologies related with endocrine disorders, gynecological abnormalities, autoimmune, genetic, and neoplastic diseases, as well as pregnancy-related issues. The knowledge of the ovarian continuum and the use of biomarkers to recognize ovulation should be considered a powerful tool for women and medical professionals. Summary:The ovarian continuum is a process that occurs during a woman's lifetime. It begins during intrauterine life with fertilization and ends with menopause. This process can be greatly affected by different conditions such as changes in hormonal levels and illnesses. Therefore, understanding and promoting the knowledge and use of biomarkers of ovulation in women is a key aspect to consider when evaluating their health status. The knowledge and education about the ovarian continuum should be taken into account as a powerful tool for women and medical professionals.

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The Role of Kisspeptin in the Onset of Puberty and in the Ovulatory Mechanism: A Mini-review

Cited by 48 publications

References 48 publications

DNA Methylation Patterns in the Hypothalamus of Female Pubertal Goats

DNA Methylation Patterns in the Hypothalamus of Female Pubertal Goats

Puberty and the Evolution of Developmental Science

Ovulation, A Sign of Health

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