2024
DOI: 10.1038/s41514-024-00165-1
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The role of Klotho and sirtuins in sleep-related cardiovascular diseases: a review study

Farzaneh Rostamzadeh,
Siyavash Joukar,
Mahboobeh Yeganeh-Hajahmadi

Abstract: The prevalence of sleep disorders has been reported from 1.6% to 56.0%, worldwide. Sleep deprivation causes cardiovascular diseases (CVDs) including atherosclerosis, vascular aging, hypertension, heart dysfunction, reduced heart rate variability, and cardiac arrhythmia. Reduced tissue oxygen causes various CVDs by activating pro-inflammatory factors and increasing oxidative stress. Sleep disorders are more important and prevalent in older people and cause more severe cardiovascular complications. On the other … Show more

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