Abstract:Prolidase, also known as peptidase D (PEPD), is a hydrolase that cleaves dipeptides containing C‐terminal proline or hydroxyproline. These dipeptides are generated largely during collagen turnover, therefore prolidase catalysis is an essential rate‐limiting step during collagen biosynthesis. Consequently, prolidase plays a significant role in collagen metabolism, matrix remodeling, and wound healing. Defective wound healing is one of the hallmarks of Prolidase Deficiency, a rare autosomal recessive disorder ch… Show more
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