The Role of Laryngopharyngeal Reflux as a Risk Factor in Laryngeal Cancer: A Preliminary Report

Tae, Kyung; Jin, Bong Joon; Ji, Yong Bae; Jeong, Jin Hyeok; Cho, Seok Hyun; Lee, Seung Hwan

doi:10.3342/ceo.2011.4.2.101

Cited by 47 publications

(58 citation statements)

References 17 publications

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“…Use of coal (Sapkota et al, 2013) and silica dust exposure have also been implicated (Chen and Tsu, 2012). A similar irritation dependent mechanism might be relevant for the finding that gastrectomy for peptic ulcer disease might entail a long-term increase (Lagergren and Lindam, 2012) as does laryngopharyngeal reflux (Tae et al, 2011) but apparently not gastroesophageal reflux (Coca-Pelaz et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Evaluation of Laryngeal Cancer Incidence in Kazakhstan for The Years 1999-2009

Igissinov¹,

Zatoskikh²,

Moore³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The purpose was to provide a descriptive epidemiological assessment of the incidence of cancer of the larynx in Kazakhstan and spatial evaluation with gender characteristics. Thgis retrospective study covered all new cases of laryngeal cancer in 11 years (1999-2009). The total number was 4,967 cases, 4,535 (91.3%) in males and 432 (8.7%) in women, with a ratio of 10.5:1. The higher incidence in men compared to women was evident in all age groups, the differences being statistically significant (p<0.05). At the same time revealed a unimodal growth with age, peaking at 70 years and older both sexes. In the dynamics, incidence rates of laryngeal cancer demonstrated a tendency to decrease, in women (T=−6.7%) this being more pronounced than in men (T=−3.3%). Levels were determined to produce cartograms of cancer of the larynx for male and female populations, clear geographical variation being evidenced. The data are discussed with reference to possible risk factors.

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Section: Introductionmentioning

confidence: 99%

Epidemiological Evaluation of Laryngeal Cancer Incidence in Kazakhstan for The Years 1999-2009

Igissinov¹,

Zatoskikh²,

Moore³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The medium was replaced with DMEM containing 20, 30 or 40 µM xanthohumol and cells were cultured for 48 h at 4˚C. SCC4 cells (1x10 6 ) were harvested, washed with PBS, and lysed with cold RIPA buffer (BestBio) containing protease inhibitors. Protein concentrations were quantified using the bicinchonic acid assay method (BestBio).…”

Section: Western Blot Analysis Scc4 Cells (24x10mentioning

confidence: 99%

“…The medium was replaced with DMEM containing 20, 30 or 40 µM xanthohumol and cells were cultured for 48 h at 4˚C. SCC4 cells (1x10 6 ) were harvested, washed with PBS and resuspended in binding buffer. A total of 1 µl fluorescent substrate [Ac-DEVD-pNA for caspase-3, Ac-IETD-pNA for caspase-8 and Ac-LEHD-pNA for caspase-9 (BestBio, Shanghai, China)] was added to each well and incubated for 1 h at 4˚C.…”

Section: Measurement Of Caspase-3 -8 and -9 Activity Scc4 Cells (2mentioning

confidence: 99%

“…The medium was replaced with DMEM containing 20, 30 or 40 µM xanthohumol and cells were cultured for 48 h at 4˚C. SCC4 cells (1x10 6 ) were harvested, washed with PBS and resuspended in binding buffer (BestBio). Next, 5 µl Annexin V-FITC and 5 µl PI were added to each well and cultured for 20 min at 4˚C.…”

Section: Annexin V-fitc/pi Staining Scc4 Cells (24x10mentioning

confidence: 99%

“…Due to recent advances in minimally invasive surgery, radiotherapy, chemotherapy, concurrent radiochemotherapy, biological therapy and other comprehensive treatment modalities, patient survival times have increased and patient quality of life has improved (5). However, the high rates of relapse and metastasis of laryngeal cancer in addition to chemotherapy resistance lead to poor treatment outcomes (6,7). Thus, to investigate and develop novel targeted treatments for cancer, laryngeal cancer must be investigated from a novel perspective.…”

Section: Introductionmentioning

confidence: 99%

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Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma

Wang

Yin

et al. 2016

Oncology Letters

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Abstract. Xanthohumol is a flavonoid compound that exhibits antioxidant and anticancer effects, and is used to treat atherosclerosis. The aim of the present study was to investigate the effect of xanthohumol on the cell proliferation of laryngeal squamous cell carcinoma and to understand the mechanism of its action. The effects of xanthohumol on the cell viability and apoptosis rate of laryngeal squamous cell carcinoma SCC4 cells were assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining. In addition, the expression levels of pro-apoptotic proteins, caspase-3, caspase-8, caspase-9, poly ADP ribose polymerase (PARP) p53 and apoptosis-inducing factor (AIF), as well as anti-apoptotic markers, B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia 1 (Mcl-1), were analyzed by western blotting. The results revealed that treatment with 40 µM xanthohumol significantly inhibited the proliferation of SCC4 cells. Furthermore, xanthohumol treatment (40 µM) induced SCC4 cell apoptosis, as indicated by the significant increase in activity and expression of caspase-3, caspase-8, caspase-9, PARP, p53 and AIF. By contrast, the protein expression of Bcl-2 and Mcl-1 was significantly decreased following treatment with 40 µM xanthohumol. Taken together, the results of the present study indicated that xanthohumol mediates growth suppression and apoptosis induction, which was mediated via the suppression of Bcl-2 and Mcl-1 and activation of PARP, p53 and AIF signaling pathways. Therefore, future studies that investigate xanthohumol as a potential therapeutic agent for laryngeal squamous cell carcinoma are required.

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Gastroesophageal reflux disease: A risk factor for laryngeal squamous cell carcinoma and esophageal squamous cell carcinoma in the NIH‐AARP Diet and Health Study cohort

Wang

Freedman

Katki

et al. 2021

Cancer

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Background Prior studies have suggested that gastroesophageal reflux disease (GERD) may be associated with risk of squamous cancers of the larynx and esophagus; however, most of these studies have had methodological limitations or insufficient control for potential confounders. Methods We prospectively examined the association between GERD and esophageal adenocarcinoma (EADC), esophageal squamous cell carcinoma (ESCC), and laryngeal squamous cell carcinoma (LSCC) in 490,605 participants of the NIH‐AARP Diet and Health Study cohort who were 50‐71 years of age at baseline. Exposure to risk factors were obtained from the baseline questionnaire. GERD diagnosis was extracted among eligible participants via linkage to Medicare diagnoses codes and then multiply imputed for non–Medicare‐eligible participants. Hazard ratios (HRs) and 95% CIs of GERD were computed using Cox regression. Results From 1995 to 2011, we accrued 931 cases of EADC, 876 cases of LSCC, and 301 cases of ESCC in this cohort and estimated multivariable‐adjusted HRs of 2.23 (95% CI, 1.72‐2.90), 1.91 (95% CI, 1.24‐2.94), and 1.99 (95% CI, 1.39‐2.84) for EADC, LSCC, and ESCC, respectively. The associations were independent of sex, smoking status, alcohol intake, and follow‐up time periods. We estimated that among the general population in the United States, 22.04% of people aged 50‐71 years suffered from GERD. Using risk factor distributions for the United States from national survey data, 16.92% of LSCC cases and 17.32% of ESCC cases among individuals aged 50‐71 years were estimated to be associated with GERD. Conclusion GERD is a common gastrointestinal disorder, but future prospective studies are needed to replicate our findings. If replicated, they may inform clinical surveillance of GERD patients and suggest new avenues for prevention of these malignancies.

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The Role of Laryngopharyngeal Reflux as a Risk Factor in Laryngeal Cancer: A Preliminary Report

Cited by 47 publications

References 17 publications

Epidemiological Evaluation of Laryngeal Cancer Incidence in Kazakhstan for The Years 1999-2009

Epidemiological Evaluation of Laryngeal Cancer Incidence in Kazakhstan for The Years 1999-2009

Xanthohumol inhibits proliferation of laryngeal squamous cell carcinoma

Gastroesophageal reflux disease: A risk factor for laryngeal squamous cell carcinoma and esophageal squamous cell carcinoma in the NIH‐AARP Diet and Health Study cohort

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