The role of leptin in diabetes: metabolic effects

Meek, Thomas H.; Morton, Gregory J.

doi:10.1007/s00125-016-3898-3

Cited by 107 publications

(69 citation statements)

References 64 publications

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“…1 Leptin receptors are widely expressed in the endocrine pancreas, liver, skeletal muscle, and adipose tissue. 2 Leptin acts on the endocrine pancreas to inhibit insulin secretion from the β cells and glucagon secretion from the α cells. Leptin acts directly on skeletal muscle to either increase or decrease glucose uptake and insulin-stimulated glucose metabolism.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Ulyanova

Baigenzhin²,

Taubaldieva³

et al. 2017

Exp Clin Transplant

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Objectives: Our objective was to determine leptin levels in patients with type 1 diabetes mellitus after fetal pancreatic stem cell transplant. Materials and Methods: Seven patients, aged 20 to 42 years, with type 1 diabetes mellitus received a fetal pancreatic stem cell transplant by intravenous infusion. The quantity of fetal stem cells infused was ≥ 5 × 10 6 , and the cells were of 12 to 14 weeks of gestation. We analyzed the levels of leptin, C-peptide, and antibodies to the islets of Langerhans before and 3 months after the transplant procedure. Results: Fetal pancreatic stem cell transplant led to significant increases in leptin and C-peptide levels, from 4.63 ± 1.17 ng/mL and 0.09 ± 0.02 ng/mL to 7.71 ± 1.45 ng/mL (P < .05) and 0.22 ± 0.05 ng/mL (P < .005), respectively, without an increase in antibodies to the islets of Langerhans, which measured 0.64 ± 0.13 U/mL before transplant and 0.57 ± 0.18 U/mL 3 months later (P > .05). Conclusions: Leptin levels increase significantly within 3 months of fetal pancreatic stem cell transplant in patients with type 1 diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

Untitled

Ulyanova

Baigenzhin²,

Taubaldieva³

et al. 2017

Exp Clin Transplant

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“…Leptin receptors are widely expressed in peripheral tissues, including the endocrine pancreas, liver, skeletal muscle, and adipose tissue. 2 Direct leptin action on the endocrine pancreas inhibits insulin secretion from β cells and glucagon secretion from α cells. Leptin acts on adipocytes to suppress insulin signaling and action.…”

Section: Introductionmentioning

confidence: 99%

“…Direct leptin action on skeletal muscle can either increase or decrease glucose uptake and insulin-stimulated glucose metabolism. 1,2 Centrally mediated actions of leptin on tissues conclude in activating leptin-responsive relays initiating in the hypothalamus that mediate leptin action on the endocrine pancreas and insulin-sensitive tissues through sympathetic and parasympathetic nervous systems. [1][2][3] Both leptin deficiency and leptin resistance profoundly affect glucose metabolism in rodents and humans.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Centrally mediated actions of leptin on tissues conclude in activating leptin-responsive relays initiating in the hypothalamus that mediate leptin action on the endocrine pancreas and insulin-sensitive tissues through sympathetic and parasympathetic nervous systems. [1][2][3] Both leptin deficiency and leptin resistance profoundly affect glucose metabolism in rodents and humans. 3 One of the potentially effective therapeutic approaches to regenerating islet cells is fetal pancreatic stem cell transplant (FPSCT).…”

Section: Introductionmentioning

confidence: 99%

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2016

Exp Clin Transplant

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Objectives: We aimed to determine leptin level in patients with type 2 diabetes mellitus after fetal pancreatic stem cell transplant. Materials and Methods: We examined 14 patients (aged 43-63 years old) with type 2 diabetes mellitus, which we subsequently divided into 2 groups and examined. Group 1 comprised 8 patients who received fetal pancreatic stem cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion; group 2 comprised 6 patients in the control group who were on hypoglycemic tablet therapy or insulin therapy. The quantity of fetal stem cells infused was 5 to 6 × 10 6 . We analyzed leptin and C-peptide levels in patients both before and 3 months after the fetal pancreatic stem cell transplant procedure. Results: In patients with type 2 diabetes mellitus, fetal pancreatic stem cell transplant led to a significant increase in leptin levels, from 11.01 ng/mL to 16.29 ng/mL, after 3 months (P < .05). Conclusions: Leptin level increase significantly within 3 months after fetal pancreatic stem cell transplant in patients with type 2 diabetes mellitus.

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“…The ulcerative colitis is an inflammatory reaction disease that associated with mobilization and recruitment some types of WBCs such as lymphocytes, neutrophils, and macrophages from the circulation to the colon mucosa. During ulcerative colitis there will be high level of neutrophils and lymphocytes infiltration in to the mucosal and sub mucosal area (Meek and Morton, 2016). Nentrophils are the most motile cells with short life span in the circulation it is one of the first responders of inflammatory cells.…”

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confidence: 99%