2023
DOI: 10.22141/2224-0721.19.6.2023.1313
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The role of leptin resistance in the development of thyroid neoplasia

O.S. Miroshnichenko

Abstract: Background. Leptin influences energy metabolism, as it is able to inform the central nervous system about adipose tissue reserves, and is also an important neuroendocrine regulator. Therefore, an increase in leptin stimulates thyrotropin-releasing hormone secretion, which leads to an increase of thyroid-stimula­ting hormone with normal or slightly elevated levels of thyroxine and triiodothyronine. Leptin imbalance leads to leptin resistance, which develops as a result of impaired sensitivity of hypothalamic re… Show more

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