In this study, the literature on the opportunities and challenges for infopreneurship was compiled using the systematic literature review (SLR) method. The study's specific goal was to look at the infopreneurship opportunities that are available and the obstacles that LIS graduates must overcome in order to take use of them. In a methodical manner, relevant research publications from journals were downloaded, reviewed, and interpreted. The researchers used numerous research strategies, such as keyword and phrase searches, to assure the precision of the study papers collected. Because basic phrase and key word searches produced substantial results, advanced search tactics like truncation and Boolean operators were not employed in this investigation. The researchers employed multiple databases, including emerald, research4life, Ebsco host, FullfreePDF, and Google scholar, with base search serving as the primary search engine. The study found out several opportunities that existed on infopreneurship, some of which include Internet blogging, software and hardware installation, graphic design, using information, customized information, facilitating access to information, repackaging information, increasing the flow of information, digitization and internetworking. The study further found a number of challenges that make it less likely for infopreneurs to seize and exploit these opportunities such as financial constraints, the price of necessary equipment, a lack of infrastructure, the legal registration process, graduates' lack of skills, and poor planning. The study concludes that information entrepreneurship is essential to any nation's economic sector. The study suggests that by reviewing LIS curricula we can increase student understanding of infopreneurship practice.