The role of life events in the onset of panic disorder

Loof, C. De; Zandbergen, J.; Lousberg, H.; Pols, Henk; Griez, Eric

doi:10.1016/0005-7967(89)90017-x

Cited by 28 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean number of life events in our sample of PD patients is also comparable to that found by other authors and is nearly identical to that found by DeLoof et al [1989], who employed the same methodology we used in this study (Paykel's schedule for life events). It should be underscored, however, that our study did not have a control group, and no evaluation of other life periods of the participants was made.…”

Section: Discussionsupporting

confidence: 83%

“…Although the role of stressful life events in precipitating the onset of PD is well acknowledged [DeLoof et al, 1989;Faravelli, 1985;Faravelli and Pallanti, 1989;Horesh et al, 1997;Manfro et al, 1996;Rapee et al, 1990;Roy-Byrne et al, 1986], no study using rigorous research methods has investigated the role of stressful life events in the onset of NP.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Nocturnal panic and recent life events

et al. 2005

View full text Add to dashboard Cite

Recent research has hypothesized an association between traumatic events and nocturnal panic (NP). The purpose of this study was to investigate whether the onset of nocturnal panic attacks is associated with a higher frequency of and/or greater severity of stressful or traumatic life events than that of patients with panic disorders (PDs) who experience daytime panic attacks (DPs) while awake. A secondary aim was to investigate whether NP is associated with specific life events at the onset of the disorder. Our sample comprised 129 subjects with PD (DSM-IV). We investigated the number and types of stressful life events that occurred in the year prior to PD onset using a semistructured interview. Of the sample, 28.7% had recurrent nocturnal panic attacks (NP group). Subjects with and without recurrent NP did not differ on any sociodemographic or clinical characteristic. Neither the number nor type of life event distinguished those with or without NP. The subgroup of patients with PD with recurrent NP appears to represent a variant of PD with a possible increased vulnerability to conditions of diminished arousal as a trigger of panic attacks. However, the hypothesis that this vulnerability might be determined by life events that occur in the period preceding PD onset was not supported by the findings of this study.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 98%

Nocturnal panic and recent life events

et al. 2005

View full text Add to dashboard Cite

show abstract

“…De Loof et al [42] 25 PD; 15 OCD Stressful Life Event Scale [13] 12 months before onset; total life course until disorder onset À (12 months before onset)…”

Section: Resultsmentioning

confidence: 99%

Life events in panic disorder-an update on “candidate stressors”

et al. 2010

View full text Add to dashboard Cite

Studies on gene-environment interactions in mental disorders are characterized by powerful genetic techniques and well defined "candidate genes," whereas a definition of "candidate stressors," in most cases assessed in the form of life events (LEs), is inconsistent or not even provided. This review addresses this problem, with particular attention to the clinical phenotype of panic disorder (PD), by providing an overview and critical discussion for which life events are known to contribute to the etiology of the disease and how they may be conceptualized. There is converging evidence for a significant impact of cumulative as well as specific life events, such as threat, interpersonal and health-related events in adulthood, and abuse or loss/separation experiences in childhood, respectively, on the pathogenesis of panic disorder with some overlapping effect across the anxiety disorder spectrum as well as on comorbid major depression. Besides genetic vulnerability factors, personality and behavioral characteristics, such as anxiety sensitivity, neuroticism, and cognitive appraisal might moderate the influence of LEs on the development of panic disorder. The present state of knowledge regarding the specification and conceptualization of LEs in PD within a more complex multifactorial model, involving mediating and moderating factors in between genes and the clinical phenotype, is hoped to aid in informing future gene-environment interaction studies in panic disorder.

show abstract

“…Also, De Loof et al (1989) [54] found that panic patients were exposed to a higher number of life events through their entire life cycle. It is replicated in this study that separation life events in total life course until disorder onset were significantly higher in the panic disorder group than in the HC group.…”

Section: Discussionmentioning

confidence: 99%

Serotonergic Genes (5-HTT and HTR1A) and Separation Life Events: Gene-by-Environment Interaction for Panic Disorder

et al. 2013

View full text Add to dashboard Cite

Background: The polymorphisms of serotonergic genes (5-HTTLPR and HTR1A rs6295) and separation life events have been studied to find an association with panic disorder, respectively. However, there are no studies that have yet evaluated the interaction effect between serotonergic genes and separation life events for panic disorder. Methods: For this study, 194 panic disorder patients and 172 healthy controls were included for genotyping and environmental factor analysis. Separation life events were assessed using the Stressful Life Events Scale and clinical interviews. To evaluate the potential endophenotypes of panic disorder, the Anxiety Sensitivity Index-revised (ASI-R), harm avoidance in the Temperament and Character Inventory (HA), and neuroticism in the Eysenck Personality Questionnaire (neuroticism) scales were administered. Results: For 5-HTTLPR and HTR1A rs6295, there was no significant main effect of each genotype on panic disorder alone. However, the number of separation life events and their interaction with 5-HTTLPR showed a statistically significant effect on panic disorder. In addition, the interaction between 5-HTTLPR and the number of separation life events significantly affected the HA for potential endophenotypes. Conclusion: This study could suggest the effect of the interaction between 5-HTTLPR and separation life events on panic disorder and its potential endophenotype.

show abstract

The role of life events in the onset of panic disorder

Cited by 28 publications

References 9 publications

Nocturnal panic and recent life events

Nocturnal panic and recent life events

Life events in panic disorder-an update on “candidate stressors”

Serotonergic Genes (5-HTT and HTR1A) and Separation Life Events: Gene-by-Environment Interaction for Panic Disorder

Contact Info

Product

Resources

About