The role of lipid parameters and inflammation markers in the pathogenesis of vascular wall remodeling in hypertension patients with obesity

Petelina, T.; Gapon, L.; Musikhina, N.; Avdeeva, K.; Petrashevskaya, T.

doi:10.1016/j.atherosclerosis.2014.05.408

Cited by 1 publication

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“…The study findings also showed a significant association between levels of cystatin C and NT-ProBNP that remained after adjusting for potential confounding factors in the four study groups Previous studies showed that inflammation is involved in the occurrence and development of atherosclerosis [30,31]. The pathogenesis of human atherosclerosis also involves degradation of the extracellular matrix (ECM) and vascular wall remodeling [33,34]. An increase or decrease in vascular wall remodeling can result in the accumulation of ECM, which is the basis of the pathogenesis of diseases that include tissue repair, inflammation, and fibrosis.…”

Section: Discussionmentioning

confidence: 74%

Serum Levels of Cystatin C, N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP), and Cardiac Function in Patients with Unstable Angina Pectoris

Long

2020

Med Sci Monit

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Departmental sources Background: This study aimed to investigate the association between serum levels of cystatin C, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and cardiac function in patients with unstable angina pectoris (UAP). Material/Methods: A cross-sectional observational study was conducted at a single center and recruited 300 patients (214 men and 86 women), who were diagnosed with UAP between June 2018 to December 2018. The patients had serum levels of NT-ProBNP measured and were divided into four groups according to the serum levels of cystatin C: Q1, 0.49-0.83 mg/L; Q2, 0.84-1.04 mg/L; Q3, 1.05-1.38 mg/L; Q4, 1.39-4.21 mg/L. Cardiac function was graded according to the New York Heart Association (NYHA) class I to IV criteria. Results: In the 300 patients with UAP, there were significant differences in cardiac function and NT-ProBNP levels between the four study groups (Q1 to Q4) (p<0.05). Univariate analysis showed that body weight, heart rate, treatment with aspirin, ticagrelor, angiotensin-converting enzyme inhibitor and an angiotensin receptor blocker (ACE/ARB), diuretic use, uric acid level, and serum cystatin C levels were significantly associated with increased levels of NT-ProBNP. After adjusting for confounding factors screened in univariate analysis, multivariate regression analysis showed that increased serum cystatin C levels were significantly associated with increased levels of NT-ProBNP. Conclusions: Increased serum levels of cystatin C were associated with poor cardiac function and increased levels of NT-ProBNP in patients with UAP.

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Section: Discussionmentioning

confidence: 74%

Serum Levels of Cystatin C, N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP), and Cardiac Function in Patients with Unstable Angina Pectoris

Long

2020

Med Sci Monit

View full text Add to dashboard Cite

show abstract

The role of lipid parameters and inflammation markers in the pathogenesis of vascular wall remodeling in hypertension patients with obesity

Cited by 1 publication

References 0 publications

Serum Levels of Cystatin C, N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP), and Cardiac Function in Patients with Unstable Angina Pectoris

Serum Levels of Cystatin C, N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP), and Cardiac Function in Patients with Unstable Angina Pectoris

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