The role of liquid‐based cytology associated with curettage in the investigation of endometrial lesions from postmenopausal women

Papaefthimiou, Maria; Symiakaki, Hera; Mentzelopoulou, Panagiota; Giahnaki, A. E.; Voulgaris, Zannis; Diakomanolis, Emmanuel; Kyroudes, Aspasia; Karakitsos, Petros

doi:10.1111/j.1365-2303.2004.00224.x

Cited by 34 publications

(38 citation statements)

References 20 publications

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“…The main advantages of this procedure are the reduction in confounding factors, the distribution of cells on a thin layer and the possibility to obtain more slides from the same sample. The two LBP technologies currently in use include ThinPrep (Hologic Inc., Bedford, Mass., USA) and SurePath (BD Diagnostics, Burlington, N.C., USA) and several groups have reported their experience either by using ThinPrep [10,11,14,15] or SurePath [8,9,12,13] methods. There are subtle differences between ThinPrep and SurePath preparations which reflect different sampling devices, collection media and processing techniques [20,21,22,23].…”

Section: Processing Of Endometrial Lbp Methodsmentioning

confidence: 99%

“…Garcia et al [23] noted that LBP endometrial cytology has good specificity and positive predictive value for the detection of endometrial abnormalities and has a lower rate of unsatisfactory diagnoses compared to biopsy. It has been reported [10,11] that examination of just one slide provides sufficient material for cytological evaluation of an endometrial sample. Therefore, although the preparation area of LBP is smaller than conventional methods, LBP contains cells of adequate quantity and quality for a possible diagnosis [8,9].…”

Section: Cellular Findings In Lbp Methods Using Cytoarchitectural Featmentioning

confidence: 99%

“…In fact, the LBP method enables storage of a variable amount of cells. Recently, several studies have described the cellular assessment of endometrial lesions by using cytoarchitectural criteria on LBPs [8,9,10,11,12,13,14,15]. The above described advantages of LBPs versus conventional slides suggest the replacement of conventional slides with LBPs in the routine cytologic evaluation of endometrial cell samples.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Liquid-Based Preparation in the Evaluation of Endometrial Cytology

Norimatsu

Yanoh²,

Kobayashi³

2013

Acta Cytologica

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Objective: Liquid-based preparation (LBP) of the endometrial lesions is an important diagnostic tool for a variety of endometrial abnormalities because of its simplicity and high quali-quantitative diagnostic yield. We aimed to investigate the LBP method for endometrial cytology to evaluate both benign and abnormal endometrial lesions. Study Design: LBP is a semiautomated methodology that has recently become widely available and has gained popularity as a method of collecting and processing both gynecologic and nongynecologic cellular specimens. Results: Some peculiar endometrial cytoarchitectural features were described using LBPs. These were advantageous to screen as compared to conventional slides due to a smaller screening area and an excellent quality of cell preparations. Conclusions: LBP is a useful tool in the cellular diagnosis and follow-up of endometrial abnormalities, which remains complementary to the emerging molecular diagnostic cytopathology. The study of LBPs from endometrial cytology could be challenging since it is affected by numerous look-alikes and diagnostic pitfalls. This review discusses these various entities and takes into consideration the ancillary techniques that may be useful in the diagnostic procedure.

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Section: Processing Of Endometrial Lbp Methodsmentioning

confidence: 99%

Section: Cellular Findings In Lbp Methods Using Cytoarchitectural Featmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of Liquid-Based Preparation in the Evaluation of Endometrial Cytology

Norimatsu

Yanoh²,

Kobayashi³

2013

Acta Cytologica

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“…Liquid-based cytology, because of its capacity to reduce obscuring factors such as blood and inflammatory cells as well as providing a thin-layer sample, represents an opportunity to reevaluate endometrial cytology. An increasing interest in endometrial cytology is demonstrated by a number of articles reporting favorable results in terms of diagnostic accuracy [16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Surveillance for Endometrial Cancer in Women on Tamoxifen: The Role of Liquid-Based Endometrial Cytology – Cytohistological Correlation in a Population of 168 Women

Buccoliero¹,

Fambrini

Gheri³

et al. 2008

Gynecol Obstet Invest

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Aims: The aim of this study was to evaluate the utility of liquid-based cytology for endometrial surveillance in patients receiving tamoxifen. Methods: One hundred and sixty-eight women scheduled for hysteroscopy were enrolled in the study. The women sequentially underwent hysteroscopy, endometrial cytology and biopsy. Results: Endometrial biopsy only was inadequate in 112 (67%) patients, both endometrial biopsy and cytology were inadequate in 19 (11%) patients, endometrial cytology only was inadequate in 4 (2%) patients, and both endometrial biopsy and cytology were adequate in 33 (20%) patients. Overall, endometrial biopsy was inadequate in 131 (78%) patients and endometrial cytology in 23 (14%) patients. Endometrial cytology provided sufficient material for diagnosis more often than endometrial biopsy (p < 0.05). In the series of 33 patients (20%) in whom both endometrial cytology and biopsy were adequate, there was a 100% correlation between the endometrial cytology and biopsy results. Conclusions: For the first time, this study shows the diagnostic efficacy of liquid-based endometrial cytology in the follow-up of women receiving tamoxifen. It could be applied solely or in conjunction with ultrasonography.

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“…In endometrial disease, cytology is a simple, painless, inexpensive and accurate way to obtain material for cancer detection and for morphological diagnosis [12]. It can also be used to study preventive and predictive markers, including PTEN [13].…”

Section: Introductionmentioning

confidence: 99%

Expression of PTEN in Endometrial Liquid-Based Cytology

Lorito¹,

Zappacosta²,

Capanna³

et al. 2014

Acta Cytologica

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Objectives: Endometrial cytology offers a reliable alternative to biopsy in endometrial cancer detection and it may be useful in obtaining material to study prognostic and predictive markers. Over the years, new sampling devices have been developed. Molecular alterations in endometrial cancers were previously described using formalin-fixed paraffin-embedded tissues with particular attention, in endometrioid carcinomas, to the PTEN-PI3K pathway. PTEN evaluation could be useful in endometrial carcinomas for selecting patients for target therapies. Study Design: We studied 51 endometrial samples collected using the Endogyn device and 71 obtained with the Endoflower dispositive device, and processed using liquid-based cytology. Most of the cases were matched with a corresponding histological biopsy. The overall accuracy of Endoflower was 100%. Immunohistochemistry (IHC) and immunocytochemistry (ICC) for PTEN were performed using monoclonal antibody 6H2.1 from DAKO. Results: The IHC showed PTEN-null glands in 4 cases. The same cancers were negative in ICC. Among the 10 carcinomas on cytology, PTEN-null glands were found in 1 case. All the normal endometrium control cases were positive in cytology and histology. Conclusions: Our results suggest that endometrial devices provide useful material for the diagnosis and evaluation of PTEN expression.

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The role of liquid‐based cytology associated with curettage in the investigation of endometrial lesions from postmenopausal women

Abstract: Endometrial sampling is complementary to D&C for the diagnosis of endometrial lesions and it is necessary for it to be performed before D&C and/or hysterectomy.

Cited by 34 publications

References 20 publications

The Role of Liquid-Based Preparation in the Evaluation of Endometrial Cytology

The Role of Liquid-Based Preparation in the Evaluation of Endometrial Cytology

Surveillance for Endometrial Cancer in Women on Tamoxifen: The Role of Liquid-Based Endometrial Cytology – Cytohistological Correlation in a Population of 168 Women

Expression of PTEN in Endometrial Liquid-Based Cytology

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