The role of liquid‐based cytology in the investigation of thyroid lesions

Stamataki, M.; Anninos, Dionisis; Brountzos, Elias; Georgoulakis, J.; Panayiotides, John; Christoni, Zoi; Peros, George; Karakitsos, Petros

doi:10.1111/j.1365-2303.2007.00512.x

Cited by 53 publications

(51 citation statements)

References 14 publications

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“…[7][8][9][10] More recent studies, however, have supported comparable or better results with liquid-based cytology. [11][12][13] Most published articles discuss thyroid FNAC using the ThinPrep system. [7][8][9][10]12,13 The reported inadequate rates varied from 22% up to 41%.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13] Most published articles discuss thyroid FNAC using the ThinPrep system. [7][8][9][10]12,13 The reported inadequate rates varied from 22% up to 41%. Sensitivity and specificity varied from 87% to 94% and from 67% to 99%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Sensitivity and specificity varied from 87% to 94% and from 67% to 99%, respectively. 8,13,14 Jung et al compared the efficacy of the SurePath to conventional smears in thyroid FNAC. 4 In their study, SurePath showed increased cellularity and more clustered tissue fragments.…”

Section: Discussionmentioning

confidence: 99%

“…23,24 In several studies on thyroid FNAC, the size of the punctured nodules is not mentioned. 2,8,9,13,14 Nevertheless, the rate of adequate FNAC is lower is small nodules. 25 Finally, the liquid-based technique itself could also be responsible for the high rate of inadequate samples, but we did not observed a decrease in slide cellularity after liquid-based cytology was introduced in our center.…”

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confidence: 99%

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Liquid‐based FNAC of the thyroid

Geers

Bourgain²

2010

Cancer Cytopathology

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BACKGROUND:The aims of this study were to analyze cytomorphological features of Tripath PREP (BD SurePath, Burlington, NC) preparations in thyroid nodules and to examine adequacy and accuracy of SurePath and frozen sections for both clinical outcome and histological diagnosis when applicable.METHODS:Gathered during a period of 4 years, 712 SurePath specimens of the thyroid were included. Histological (n = 207) or clinical follow‐up (n = 505) was available in all cases. During the same period, 253 frozen sections of surgical thyroid resection specimens were also assessed. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were calculated.RESULTS:Sensitivity was 77% for SurePath and 29% for frozen section; specificity was 81% for SurePath and 100% for frozen section; accuracy was 80% for SurePath and 90% for frozen section. One hundred seventy‐eight (25%) SurePath patients were considered unsatisfactory for diagnosis. In this study, sensitivity, specificity, and accuracy were comparable for SurePath and other reported results of liquid‐based thyroid cytology. Presence of free colloid or pure cystic changes favored a benign diagnosis. Cellular smears with nuclear atypia of papillary carcinoma allowed an overt diagnosis of malignancy.CONCLUSIONS:The authors concluded that SurePath is a reliable technique for assessment of thyroid nodules and offers the advantage of easy identification of colloid and atypical nuclei. Supplementary frozen section analysis should be limited to an FNAC diagnosis of suspicious for papillary carcinoma. Cancer (Cancer Cytopathol) 2011. © 2010 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Liquid‐based FNAC of the thyroid

Geers

Bourgain²

2010

Cancer Cytopathology

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“…The study was not blinded. We defined specimens as adequate by the presence of at least six groups of cells with a minimum number of well-visualised ten cells in each group [5,6]. Table 3 shows the rates of cytological characteristics in malignant and benign lesions in each TP-PAP slide according to criteria in references 3, 6 and 21.…”

Section: Malignant (N=18)mentioning

confidence: 99%

Cytomorphologic Evaluation of the Thin Prep for Fine Needle Aspiration of the Fresh Thyroidectomy Specimens

BaAA¹,

Keser²,

Erenler³

2017

J Cytol Histol

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Objective: This study aimed to compare cytomorphology of ThinPrep Papanicolaou (TP PAP) method with the macroscopic-microscopic findings of the nodules on fresh thyroidectomy specimens.Study Design: A total of 75 thyroid surgical specimens were included in our study. Fine Needle Aspiration Biopsy (FNAB) of specimens was performed by a pathologist. Aspirate was taken into TP liquid and stained with PAP. We defined cytological findings, compatible with macroscopic-microscopic findings. Results:In cytologic evaluation 108 nodules were diagnosed benign, while 18 nodules were malignant and 2 cystic nodules were insufficient. Cytological diagnosis was compatible with histologically benign a total of 110 nodules, and 18 malignant nodules. Nuclear groove/irregular nuclear membrane, nuclear overlap/crowding, nuclear enlargement, nuclear pseudoinclusion, pale/fine chromatin are determined as statistically significant cytological parameters in malignant cases. Conclusion:FNAB and the histo-morphological and TP PAP cytological slides were evaluated by pathologists at every stage of biopsy process. It is clearly understood how important it is to obtain adequate cells from the benign or malignant thyroid nodules with this method. Although controversial opinions among the cytopathologists regarding the association using TP method are present, in this study we revealed that TP method is easy to use for FNAB.

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Cytologic features of parathyroid fine‐needle aspiration on ThinPrep preparations

Odronic

Reynolds

Chute

2014

Cancer Cytopathology

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BACKGROUND: Previous studies have provided cytologic criteria that aid in the recognition of parathyroid tissue on aspirate smears, including high cellularity, the presence of naked nuclei, loose 2-dimensional clusters, and papillary architecture. However, to the authors knowledge, the cytomorphologic features of parathyroid fine-needle aspiration (FNA) on liquid-based preparations have not been previously described. METHODS: The authors retrospectively reviewed all parathyroid FNAs that had aspirate smears and a ThinPrep preparation performed over 10 years at 1 institution. The FNA smears and ThinPrep preparations from each case were deidentified and independently reviewed for cellularity, naked nuclei, architecture, and colloid-like material. RESULTS: Forty patients were included in the current study. When individual cases were compared, the ThinPrep preparation was more likely to have lower cellularity, lack papillary architecture, lack

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The role of liquid‐based cytology in the investigation of thyroid lesions

Cited by 53 publications

References 14 publications

Liquid‐based FNAC of the thyroid

Liquid‐based FNAC of the thyroid

Cytomorphologic Evaluation of the Thin Prep for Fine Needle Aspiration of the Fresh Thyroidectomy Specimens

Cytologic features of parathyroid fine‐needle aspiration on ThinPrep preparations

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