The role of lithium treatment on comorbid anxiety symptoms in patients with bipolar depression

Jones, Gregory; Rong, Carola; Vecera, Courtney M.; Gurguis, Christopher I.; Chudal, Roshan; Khairova, Rushaniya; Leung, Edison; Ruiz, Ana; Shahani, Lokesh R; Zanetti, Marcus V.; Sousa, Rafael T. de; Busatto, Geraldo F.; Soares, Jair C.; Gattaz, Wagner F.; Machado‐Vieira, Rodrigo

doi:10.1016/j.jad.2022.04.025

Cited by 5 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found out that patients with BD visiting TCM clinicians may relate to anxiety. Lithium has an essential role in treating comorbid anxiety in BD in patients who were medication-free primarily and lithium-naïve at baseline [52]. However, patients with high anxiety scores had low lithium responsivity [53].…”

Section: Demographic Characteristicsmentioning

confidence: 99%

Usage Patterns of Traditional Chinese Medicine for Patients with Bipolar Disorder: A Population-Based Study in Taiwan

Chen,

Yang,

et al. 2024

Healthcare

View full text Add to dashboard Cite

Background: Patients with bipolar disorder (BD) receive traditional Chinese medicine (TCM) for clinical needs unmet with psychotropic medications. However, the clinical characteristics of practices and outcomes of TCM in BD are not fully understood. This cohort study investigated the clinical characteristics, principal diagnoses, TCM interventions, and TCM prescriptions in patients with BD. Methods: Data for a total of 12,113 patients with BD between 1996 and 2013 were withdrawn from Taiwan’s longitudinal health insurance database 2000 (LHID 2000). The chi-square test was used for categorical variables, and the independent t-test was used for continuous variables. A p-value less than 0.05 indicated significance. Results: One thousand three hundred nineteen patients who visited TCM clinics after the diagnosis of BD were in the TCM group, while those who never visited TCM were in the non-TCM group (n = 1053). Compared to the non-TCM group, patients in the TCM group had younger average age, a higher percentage of female individuals, more comorbidities of anxiety and alcohol use disorders, and higher mood stabilizer usage rates. The TCM group exhibited pain-related indications, including joint pain, myalgia, myositis, headache, and sleep disturbances. Corydalis yanhusuo and Shu-Jing-Huo-Xue-Tang were the most useful single herbs and herbal formulae. Conclusions: Physicians need to be aware of the use of TCM in patients with BD.

show abstract

Section: Demographic Characteristicsmentioning

confidence: 99%

Usage Patterns of Traditional Chinese Medicine for Patients with Bipolar Disorder: A Population-Based Study in Taiwan

Chen,

Yang,

et al. 2024

Healthcare

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…10,11 Meanwhile, lithium carbonate has been the first choice to stabilise the mood of patients suffering from bipolar disorder and prevent self-harm by significantly improving depression and anxiety. [12][13][14] However, dopamine is readily oxidized when released from vesicles into the cytosol, and some oxidation products, such as semiquinone radicals, have been proposed to be highly toxic, 15 with adverse effects on the nervous system. 16,17 Hence, whether olanzapine and lithium carbonate have effects on the dopamine oxidation process has become an important issue.…”

Section: Introductionmentioning

confidence: 99%